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RISS 인기검색어
- 검색키워드
- 저자 : 이무형(My Hyoung Lee) (검색결과 3 건)
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배양 정상 인체 멜라닌세포의 증식과 멜라닌화에 8 - Methoxypsoralen이 미치는 영향
이무형(My Hyoung Lee),유한동(Han Dong Yoo),박재경(Jai Kyung Park),허충림(Choong Rim Haw) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.5
Background : Psoralen has been used in the treatment of certain hypojigmentary disorders with UVA or solar irradiation. However trecent report proposed the actions of psiralens are direct and do not require the presence of ultraviolet light. The report also suggested that tze specific receptors other than DNA would be present. Objective : This study was done ta identify the effects of 8-methoryporalen(8-MOP) on the proliferation and melanization of cultured normal human melanocytes without UVA. Methods : Melanocytes were cultured in melanocyte culture medium neluding 16% or 5% FBS. We added 8-MOP by their concentrations from 10 M to 10 M. After 8 hours treatment, we investigated the melanocytes proliferation and Lhe melanin contents. Results : We could not detecet any significant differences of melanoytes proliferation and melanin contents between the control end experimental groups. Conclusion : There were no effect on the proliferation and the milanization of cultured normal human melanocytes with 8-MOP onl. (Kor J Dermatol 1994;32(5),:832-837)
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조갑진균증에 대한 Amorolfine Nail Lacquer 5 % 1주 1회 도포 요법의 치료 효과 - 공동연구 -
은희철 ( Hee Chul Eun ),이무형 ( My Hyoung Lee ),김수남 ( Soo Nam Kim ),유희준 ( Hee Joon Yoo ),권경술 ( Kyung Sool Kwon ),김수찬 ( Soo Chan Kim ),이재승 ( Jae Seung Lee ),김방순 ( Bang Soon Kim ),정병수 ( Byoung Soo Chung ),장승 대한피부과학회 1995 대한피부과학회지 Vol.33 No.2
Backgound : Amorolfine is a new topical antifungal drug of the mopholine class which has broad spectrum fungicidal activity. Amorolfine nail lacquer 5% is a transingal delivery system which can penetrate well through the nail plate to the infected keratin and reman here for a prolonged period. Objective : The aim of this study is to assess the efficacy and tole at hty of 5% amorolfine nail lacquer given once weekly to the patients with onychomycosis. Methods : 29 patients with onychomycosis affecting not more that 80% of the surface of nail were treated once weekly for up to 9 months with amorolfine nail lacquer 5%. Clinical and mycological examination were performecl before treatment and 3, 6, 9 months after short of treatment. Final evaluation was done 3 months after the end of treatment. Results : Average affected area(%) and average score of clinical igsthickening, splitting, discoloration were significantly decreased 3 months after start of treatment. Mycological cure rate was continuously increased accorcling to the treatment duration reaching 75.9, at 3 months after treatment. Overall efficacy assessed by the investgators were cure in 31.0 % and improvement in 41.4%. Tolerability, mode and frequency of treatment, and formulation were evoluated as good or excellent by most of the patients. No systemic or local side effect was observed. Conclusion : Amorolfine nail lacquer 5% used once weekly up to 3 onths was relatively effective and safe for the treatment of cnychomycosis. (Kor J Dermatol 1995 3 (2): 314-321)
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건선 치료에 대한 Calcipotriol ( MC 903 ) 연고의 임상연구
윤태진(Tae Jin Yoon),김진환(Jin Hwan Kim),심우영(Woo Young Sim),이무형(My Hyoung Lee),김낙인(Nack In Kim),허충림(Choong Rim Haw) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.2
Background: We have already shown that a new vitamin D3 analogue, calcipotriol is a potent growth inhibitor for human keratinocytes, indicating the close relationship between the in vitro inhibitory effect of calciipotriol and its therapeutic effectiveness or psoriasis. Objective : Our purpose was to evaluste the clinical efficscy, safety and tolerability of calcipotriol (50ug/g) ointment twice daily in the treatment of psoriasis. Methods : We treated 31 patients with calcipotriol for 6 weeks. Patients were provided with a maximum of 100g of ointment per week. Efficacy, as measured by the Psoriasis Area and Severity Index(PASI), and safety were assessed at 2,4, and 6 weeks. Results ; Reduction of PASI was stastistically significant at all time points for treatments (p<0.01). At the completian of 6 weeks of treatment, the mean PASI reduction was 3.61. An analysis of patient overall self-assessment, at 6 weeks showed clearance or marked improvement in 61%. Some patients developed minimal irriltation of lesional or perilesional skin(6.5%). Laboratory tests did not show any significant changes, in particular there was no change in serum calcium levels. Conelusions : Calcipotriol ointment was effective as measured by the PASI and the self-assessment in patients with psoriaeis. This treatrnent was well tolerated. (Kor J Dermatol 1993; 31(2): 217-223)
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