급성골수성백혈병의 Adriamycin 과 Ara - C 병합요법에 의한 관해유도효과

이규보 ( Kyu Bo Lee ),황기석 ( Kee Suk Whang ),이재태 ( Jae Tae Lee ),유만준 ( Man Joon Yu ) 대한내과학회 1985 대한내과학회지 Vol.28 No.4

심근관류 스캔중에 나타난 Thallium - 201의 심장외 국소적 섭취

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),정병천(Byung Cheon Chung),최정일(Chung Il Choi),곽동석(Dong Suk Kwak),박무근(Moo Keun Park) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.1

N/A Myocardial perfusion imaging with 201T1-chloride following exercise or vasodilator-induced hyperemia has been effective in detecting the presence of coronary artery disease. An increased lung uptake of thallium has been reported as a sensitive marker of severe and extensive coronary artery disease and associated with poor prognosis. Thallium has also been noted to concentrate in a variety of malignant lesions. We report 5 cases of extracardiac uptake of thallium during myocardial perfusion scan with pharmacologic vasodilation. Accumulation of thallium was found in the lesions of a breast cancer, a lung cancer, a Castleman's disease and 2 cases of thymoma. We believe that the presence of focal extracardiac uptake of thallium during myocardial perfusion scan should suggest the need for further clinical evaluation to detect the tumor and must differentiate the increased lung uptake of thallium due to left ventricular dysfunction in coronary artery disease.

99mTc-MDP 골스캔에서 위출혈에 의한 위장관의 일과성 방사능 집적

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),천경아(Kyung Ah Chun),이상우(Sang Woo Lee) 대한핵의학회 1998 핵의학 분자영상 Vol.32 No.2

We present a case in which a patient with acute hemorrhagic gastritis demonstrated abnormal gastrointestinal accumulation of radiotracer during Tc-99m-methylene diphosphonate (MDP) skeletal scintigraphy. A hemorrhage gastritis was subsequsently demonstrated by endoscopy. The menchanism for the intestinal localization of Tc-99m-MDP in this patient is not clear, but we guess that the extravasated blood containing the radiopharmaceutical cannot recirculate and stays at the bleedings site, so we can see the intestinal activity.

자가면역성 갑상선질환에서의 혈청 Thyrotropin - Binding Inhibiting Immunoglobulin치

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),손상균(Sang Kyun Sohn),장대성(Dae Sung Jang),안병철(Byeong Cheol Ahn) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.1

N/A In order to evaluate the significance of thyrotropin-binding inhibiting immunoglobulin (TBII) in the patients with autoimmune thyroid diseases, the authors investigated 402 cases of Graves' disease and 230 cases of Hashimoto's thyroiditis comparing 30 cases of normal healthy adult at Kyung Pook University Hospital from February 1993 to August 1994. The TBII was tested by radioimmunoassay and assesed on the dynamic change with the disesase course, thyroid functional parameters, and other thyroid autoantibodies; antithyroglobulin antibody(ATAb) and antimicrosomal antibody(AMAb) including thyroglobulin. The serum level of TBII was 40.82±21.651(mean±SD)% in hyperthyroid Graves' disease and 8.89±14.522% in Hashimoto's thyroiditis and both were significant different from normal control of which was 3.21±2.571%. The frequency of abnormally increased TBII level was 92.2% in hyperthyroid Craves' disease, 46.7% in euthyroid Graves' disease or remission state of hyperthyroidism, and 23.9% in Hashimoto's thyroiditis. The serum levels of increased TBII in Graves' disease were positively correlated with RAIU, serum T3, T4, and FT4, but negatively correlated with serum TSH(each p〈0.001). The TBII in Graves' disease had significant positive correlation with serum thyroglobulin and AMAb, but no significant correlation with ATAb. In the Hashimoto's thyroiditis, the serum levels of TBII were positively correlated with RAIU, serum T3, TSH and AMAb, but not significantly correlated with serum T4, FT4, thyroglobulin and ATAb. Therefore serum level of TBII seemed to be a useful mean of assessing the degree of hyperthyroidism in Graves' disease and correlated well with thyroidal stimulation. The serum level of TBII in Hashimoto's thyroiditis is meaningful for the degree of both functionl abnormality reflecting either hyperfunction or hypofunction and the immunologic abnormality.

ECG Gated Blood Pool Scan을 이용한 심실벽 역행성 운동의 평가 - Cine Loop , Phase analysis , Paradox Image의 비교 -

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),황기석(Kee Suk Whang),정병천,전재은,정진홍(Jin Hong Chung),김광원(Gwang Weon Kim),채성철(Sung Chul Chae),박의현(Wee Hyun Park),이형우(Hyong Woo Lee) 대한핵의학회 1990 핵의학 분자영상 Vol.24 No.2

N/A Sixty-four patients with paradoxical ventricular wall motion noticed both in angiocardiography or 2-dimensional echocardiography were assessed by ECG gated blood pool scan (GBPS). Endless cine loop image, phase and amplitude images and paradox image obtained by visual inspection of each cardiac beat or Fourier transformation of acquired raw data were investigated to determine the incremental value of GBPS with these processing methods for identification of paradoxical ventricular wall motion. The results were as follows:1) Paradoxical wall motions were observed on interventricular septum in 34 cases, left ventricular free wall in 26and right ventricular wall in 24. Underlying heart diseases were is chemic (23 cases) valvular(9), congenita1 heart disease (12), cardiomyopathy (5). pericardial effusion(5), post cardiac surgery(3), cor pulmonale (2), endocarditis (l) and right ventricular tumor(l). 2) Left ventricular ejection fractions of patients with paradoxical left ventricular wall motion were significantly lower than those with paradoxical septal motion (p〈0.005). 3) The sensitivity of each processing methods for detecting paradoxical wall motion was 76.9% by phase analysis, 74.6% by endless cine loop mapping and 68.4% by paradox image manipultion respectively. Paradoxial motions visualized only in phase, paradox or both images were appeared as hypokinesia or akinesia in cine loop image. 4) All events could be identified by at least one of above three processing methods, however only 34 cases (48.4%) showed the paradoxical motions in all of the three images. By these findings, we concluded that simultaneous inspection of all above three processing methods-endless cine loop, phase analysis and paradox image is necessary for accurate identification and assessment of paradoxical ventricular wall motion when performing GBPS.

복막투석환자에서의 개존된 Processue Vaginalis - 방사성핵종복막촬영술로 확진된 2예 -

이규보(Kyu Bo Lee),손상균(Sang Kyun Son),이재태(Jae Tae Lee),황기석(Kee Suk Whang),조동규(Dong Kyu Cho),고철우(Chul Woo Koh) 대한핵의학회 1989 핵의학 분자영상 Vol.23 No.2

Continuous ambulatory peritoneal dialysis (CAPD) is a well established method of treating end stage renal failure, and is commonly used as an alternative to hemodia]ysis. Several complications have been observed. These include catheter rnalfunction, abdominal and inguinal hernia, and peritonitis. A relatively frequent complication is swetling of externa] geniitalia, due to bowel fluid passing through a patent processus vaginalis. Special diagnostic procedures are necessary to dctermine the nature of the abnormality and to guide the surgical correction. We reported two cases of patent processus vaginalis in patient on CAPD proved by radionuclide peritonea1 scintiscan using Tc-99 m-tin colloid.

두경부 종양에서 99mTc - ( V ) - DMSA 영상술의 진단적 유용성

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),김정균(Jeong Gyun Kim),배선근(Sun Kun Bae),박준식(June Sik Park),박인규(In Kyu Park),현동우(Dong Woo Hyun),이영학(Young Hak Lee),안병철(Byeong Cheal Ahn),최지용(Ji Yong Choi),손상균(Sang Gyun So 대한핵의학회 1995 핵의학 분자영상 Vol.29 No.4

N/A Introduction: Tc-99m-(V)-DMSA is a tumor seeking agent that has been used to image medullary carcinoma of thyroid, soft tissue sarcoma and lung cancer. This study was designed to assess the clinical role of Tc-99m-(V)-DMSA in the diagnosis of head and neck cancers. We has evaluated the diagnostic efficacy of planar and SPECT imaging using Tc-99m-(V)-DMSA. Patients and Method: Sixty-eight patients with head and neck mass were included in this study. All subjects were diagnosed by biopsy or surgery. Planar and SPECT images were obtained at 2 or 3 hour after intravenous injection of 740 MBq(20 mCi) Tc-99m-(V)-DMSA. Seventeen patients also underwent SPECT imaging using dual head camera. Results: The diagnostic sensitivity of Tc-99m-(V)-DMSA planar and SPECT imaging was 65% and 90%, and specificity was 80% and 66%, respectively. The sensitivity of planar imaging in squamous cell carcinoma was similar to overall sensitivity. Six metastatic lesion were first diagnosed by scintigraphy. But benign lesions such as Kikuchi syndrome, tuberculous lymphadenitis also revealed increased uptake. Conclusion: Tc-99m-(V)-DMSA imaging seems to be a promising method in the evaluation of patients with head and neck mass. We recommend SPECT imaging to delineate anatomic localization of the lesion.

Thallium-201 을 이용한 세포막 Na+-K+ ATPase 활성도 측정 ; Rubidium-86 측정법과의 비교

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),손상균(Sang Kyun Sohn),이인규(In Kyu Lee) 대한핵의학회 1998 핵의학 분자영상 Vol.32 No.2

N/A Purpose: Na+-K+ ATPase Activity has beem estimated by the degree of inhibition of cation transport by cardiac glycosides (ouabain) using Rb-86 as a substrate. The biological characterist- Isc of T1-201 is known to be simiIar to those of potassium as a transport substrate in the presence of glucose, insulin or phobol myristate acetate (PMA). The purpose of this study was to measure ouabain sensitive Na+-K+ ATPase activity using T1-201 and compare with that using Rb-86. Materials and Methods: Smooth muscle cells isolated from rat aorta or human placental umbilical artery were cultured, and used to measure cellular Na+-K+ ATPase activity. Na+-K+ ATPase activity was measured as a percentage decrease in cellular uptake of T1-201 or Rb-86 by ouabain under the presence of glucose, insulin or PMA in media. Results: Na+-K+ ATPase ase activity measured with T1-201, as a transport substrate, was not different from those measured with Rb-86 in rat or human smooth muscle cell preparation. Incubation with high concentration glucose resulted in about 30% decrease in enzyme activity. In contrast, insulin or PMA resulted in 50-70% or 28% increases from baseline activity, respectively. Conclusion: These results suggests that T1-201 could replace Rb-86 in measurement of ouabain sensititive Na+-K+ ATPase activity in vitro. High level of glucose concentration decreased cellular Na+-K+ ATPase activity, but insulin or PMA increased it.

당뇨병 환자의 위배출능 : 위배출시간 , 위저류율 및 Cisapride의 영향

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),정병천(Byung Chun Chung),최정일(Chung Il Choi),김보완(Bo Wan Kim),곽동석(Dong Suck Gwak),정준모(Jun Mo Chung) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.2

N/A Gastic emptying scan in diabetic patients is widely used to assess the degree of motility disturbance and the symtoms such as nausea, vomiting, bloating, abdominal pain and early gastric fullness which we can't find anatomic lesion by fiberoscopic or barium study. In order to determine the relationship among diabetic gastropathy, neropathy, retinopathy and disease duration, gastric emptying scan using Tc-99m-tin colloid labeled scramble egg in hamburger was performed in 10 healty male controls and 50 diabetic patients which were subdivided to no neuropathy, peripheral neuropathy and autonomic neuropathy groups according to the degree of diabetic neuropathy and no retinopathy, background retinopathy and proliferative retinopathy groups according to the degree of diabetic retinopathy. After medication of cisapride for 2 weeks, we observed the presence of improvement of gastric motility in diabetics. The results were as following: 1) In controls, gastric emptying time (GET1/2) was 75±13.6 min and 2 hour gastric retension rate(GRR2) was 32±11.1%. 2) In diabetics, GET/2 was prolonged more than 2 hours and GRR2 was 58±23.1%. According to degree of neuropathy, GET1/2 was prolonged more than 2 hours in all three groups and GRR2 was 54±24.1% in no neuropathy group, 57±24.3% in peripheral neuropathy group and 69±24.6% in autanomic neuropathy group. According to degree of retinopathy, GET1/2 was 110±23.4 min in no retinopathy group and prolonged more than 2 hours in other two groups and GRR2 was 45±21.6% in no retinopathy group, 71±19.7% in background retinopathy group and 73±21.5% in proliferative retinopathy group. 3) After cisapride for 2 weeks, GET1/2 and GRR2 were improved as 90±14.6 min and 40±13.8% (initial GET1/2 and GRR2 were above 2 hours and 61±15.4%). We can conclude from above findings that gastropathy in diabetic neuropathy suggesting main underlying factor in motility disorder. The degree of retinopathy and disease duration were correlated with severity of gastropathy in diabetics. From the results of gastric emptying scan, we can conclude that cisapride was useful drug for improving diabetic gastropathy and gastric emptying scan was valuable for assessing severity of diabetic gastropathy as non-invasive method.

관해된 급성 골수성 백혈병 환자에서 발생한 과립성 육종의 67Ga - citrate Scan 소견

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),황기석(Kee Suk Whang),김광원(Gwang Weon Kim),정병천(Byung Cheon Chung) 대한핵의학회 1990 핵의학 분자영상 Vol.24 No.2

N/A A case of a 39-year-old man with granulocytic sarcoma documented by positive Ga-67 scan is described and brief review of literature was performed. He was diagnosed as acute myelogenous leukemia and got complete remission with antileukemic chemotherapy for 7 months. On admission, picture of his bone marrow and peripheral blood showed remission state of leukemia. Radiologic examinations were performed for evaluation of lesions in head and chest, and findings of granulocytic sarcoma were suspected. So we got 67Ga-citrate scan and pleural biopsy for identification of causes of intractable pleural effusion and skin lesion. Myeloblastomas (or granular sarcomas) proved by pleural biopsy were correctly identified by 67Ga-citratre scan, and disease extent was clearly delineated. We believe that 67Ga-scintigraphy is very helpful in localizing and follow-up evaluation of granulocytic sarcoma.