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- 저자 : 윤형근(Hyung Kun Yoon) (검색결과 2 건)
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한국인에서의 도파민 수송체 유전자 다형성(Dopamine Transporter Gene(DAT1) Polymorphism)과 사회공포증과의 연관성에 관한 예비 연구
오강섭,윤형근,이민수,Oh, Kang Seob,Yoon, Hyung Kun,Lee, Min Soo 대한생물정신의학회 2004 생물정신의학 Vol.11 No.2
Objective:Although polymorphism of dopamine transporter gene(DAT1) has been considered to be implicated in the pathogenesis of social phobia, previous investigations have been inconsistent and controversial. The authors investigated the relationship between DAT1 polymorphism and social phobia in Koreans. Methods:DAT1 and alleles of fifty subjects who met DSM-IV criterion of social phobia, and those of age- & sex- matched fifty normal controls in Korea were compared. Additionally, patients were grouped into generalized(33) and nongeneralized(17) types and DAT1 polymorphism was compared with that of age- & sex- matched controls. DAT1 with variable number of tandem repeats(VNTR) were determined by using polymerase chain reaction. To compare the distribution of the DAT1 polymorphism between different groups, Fisher's exact test was used. Results:There were no significant differences in either genotypic(p=0.451) or allelic(p=0.452) distributions between the social phobia patients and the controls. There also were no differences in genotypic distribution between subtypes of social phobia patients and the controls. Conclusion:We couldn't find any association between DAT1 polymorphism and social phobia. Further studies including larger number of samples and diverse clinical variables should be conducted to elucidate the present findings.
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일 지역사회 코호트에서 정상 노인군과 경도인지장애군의 알츠하이머 치매로 진행하는 위험율 비교
김태영(Tae Young Kim),고대관(Dae Kwan Ko),손지훈(Jee Hoon Sohn),김진영(Jin Yeong Kim),이동현(Dong Hyun Lee),전홍진(Hong Jin Jeon),장성만(Sung Man Chang),이유라(You Ra Lee),최지환(Ji Hwan Choi),윤형근(Hyung Kun Yoon),조맹제(Maeng Je C 대한사회정신의학회 2008 사회정신의학 Vol.13 No.1
국내 지역사회 거주 노인을 대상으로 한 이번 연구에서 경도인지장애가 있는 경우는 그렇지 않은 경우에 비해 18개월 후 알츠하이머 치매로 진행할 확률이 통계적으로 유의하게 높았다. 따라서 지역사회에서 경도인지장애가 있는 노인을 선별하고, 그들을 대상으로 알츠하이머 치매로의 진행을 늦출 수 있는 적절한 개입을 하는 것이 중요하다. Objectives:The aim of this study is to compare the conversion rates to Alzheimer dementia between the normal elderly group and the mild cognitive impairment group at the community cohort. Methods:Among the 229 nondemented elderly who had undergone the first wave in 2006, 70 subjects completed the second wave 18 months later. We used the Korean version of Mini Mental Status Exam(MMSE-K), the Korean version of the CERAD(Consortium to Establish a Registry for Alzheimer’s Disease) neuropsychological batteries, the Korean version of Geriatric Depression Scale, and the Instrumental Activities of Daily Living scale. Psychiatrists diagnosed mild cognitive impairment and Alzheimer dementia by Petersen criteria and Diagnostic and Statistical Manual of Mental Disorders fourth edition(DSM-IV) criteria. We used the multivariate logistic regression to calculate the odds ratio for the conversion to Alzheimer dementia between two groups. Results:While only one subject converted to Alzheimer dementia among 43 normal elderly(2.3%), there were 5 Alzheimer dementia conversions out of 21 mild cognitive impairment cases(23.8%). The odds ratio between two groups is about 30. No other clinical variables predicted progression toward Alzheimer dementia. Conclusion:The elderly with mild cognitive impairment has higher risk of conversion to Alzheimer dementia than the normal elderly in the community cohort.
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