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이재영 ( Jae Young Lee ),윤녕훈 ( Nyung Hoon Yoon ),박석돈 ( Seok Don Park ) 대한피부과학회 2006 대한피부과학회지 Vol.44 No.11
Background: Pain and paresthesia often precede the eruption of herpes zoster and vary from itching to stabbing. The preeruptive pain may simulate other diseases and may lead to misdiagnosis and misdirected interventions. Objective: The aim of this study was to elucidate the clinical characteristics of herpes zoster and its nature of pain. Methods: Three hundred and thirty three patients who were admitted with herpes zoster during a 10-year period from 1995 to 2004 were evaluated in regard to age, sex, dermatomal distribution, associated diseases, and complications. Patients were further assessed concerning the nature of the pain and its relationship to age, sex, dermatomal distribution, and postherpetic neuralgia. Results: Herpes zoster was seen most frequently in the 70~79 year-old age group (30.9%), and the ratio of male to female patients was 1:2.2. The most common dermatomal distribution was thoracic dermatome (39.6%), followed by trigeminal (30.9%), cervical (11.7%), lumbar (7.2%), sacral (2.7%), and multiple dermatomal involvement (4.5%). Associated diseases to herpes zoster were observed in 180 patients (54.1%) which included hypertension (18.6%), diabetes mellitus (8.7%), gastritis and gastric ulcer (6.0%), fatty liver and hepatitis (5.1%), pulmonary tuberculosis (3.3%), malignancy (2.7%), rheumatoid arthritis (1.8%), and various other conditions (7.9%). The most common complication of herpes zoster was postherpetic neuralgia (15.6%), followed by ocular complications (6.9%), secondary infection (1.5%), scar formation (0.9%), Ramsay-Hunt syndrome (0.6%), and a neurogenic bladder (0.3%). The most common nature of pain associated with herpes zoster was pricking or stabbing (68%), followed by a dull ache (8.1%), tingling (7.2%), burning (4.2%), numbness (3.9%), throbbing (2.1%), a water trickling sensation (1.5%), itching (1.5%), formication (1.2%), soreness (0.9%), bursting (0.6%), sensation of being pulled down (0.3%), and sensation of cold water being poured on the skin (0.3%). Paresthesia was observed in 11 patients (3.3%), and 8 of these complained of this in the trigeminal dermatome (72.7%). Conclusion: Higher incidences of herpes zoster were observed in female and in the 70~79 year-old age group. The nature of pain associated with herpes zoster varied from a superficial itching to severe stabbing or bursting, and paresthesia occurred most frequently in the trigeminal dermatome. (Korean J Dermatol 2006;44(11):1298~1303)
신장 이식 후 Cyclosporine 투여 중 발생한 다발성 피지선 증식증 2예
김현대 ( Hyun Dai Kim ),이재영 ( Jae Young Lee ),윤녕훈 ( Nyung Hoon Yoon ),박석돈 ( Seok Don Park ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.1
Sebaceous hyperplasia can occur on the face during middle age, particularly in men. The risk of sebaceous hyperplasia is significantly increased in adult transplant patients, particularly males, following renal transplantation, and this is related to therapy with cyclosporine. We report on 2 cases of sebaceous hyperplasia in renal transplant patients who were treated with cyclosporine. The condition was improved, without scarring, by treatment with carbon dioxide laser or cryotherapy. (Korean J Dermatol 2007;45(1):69~71)
김현대 ( Hyun Dai Kim ),원태혁 ( Tai Hyok Won ),서필승 ( Phil Seung Seo ),윤녕훈 ( Nyung Hoon Yoon ),박석돈 ( Seok Don Park ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.8
Vitiligo and morphea are two distinct entities of unknown etiology, although their existence implies that the immune system and/or the central or peripheral nervous system has been incriminated. Only a few reports of their simultaneous occurrence are on record. Here we report a case of a 39 year old woman affected with both vitiligo of the face, chest and hand and morphea of shoulder and trunk. Since the two diseases appeared after bone marrow transplantation, if could be deduced that there is a possible association between them. Two diseases observed simultaneously in this patient may be derived from the common pathomechanism. An autoimmune etiology is thought to play a part in both of these diseases. (Korean J Dermatol 2007;45(8):832∼835)
이재영 ( Jae Young Lee ),김현대 ( Hyun Dai Kim ),서필승 ( Phil Seung Seo ),윤녕훈 ( Nyung Hoon Yoon ),박석돈 ( Seok Don Park ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.6
Reed`s syndrome is a rare, autosomal dominant disease with incomplete penetrance that is characterized by uterine and cutaneous leiomyomas. We report a case of Reed`s syndrome in a 50-year-old woman. The patient underwent removal of the uterine leiomyoma at the age of 36. Following this the patient noticed development of multiple, cutaneous nodules on both arms at the age of 45. These nodules progressively increased in both number and size, while appearing in other sites. The histopathologic finding of an isolated, single skin lesion showed typical leiomyoma arising from arrector pilorum muscle. Familial history revealed that her father had been affected with similar cutaneous lesions. (Korean J Dermatol 2007;45(6):612∼616)
국소 스테로이드에 의해 발생한 의인성 쿠싱 증후군 의증
김현대 ( Hyun Dai Kim ),원태혁 ( Tai Hyok Won ),서필승 ( Phil Seung Seo ),윤녕훈 ( Nyung Hoon Yoon ),박석돈 ( Seok Don Park ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.9
Chronic exogenous steroid therapy can result in hypothalamic-pituitary-adrenal axis dysfunction; this usually results from systemic steroid therapy, and is rarely associated with topical steroid therapy. We report a case of suspected iatrogenic Cushing syndrome that developed after the treatment of annular pustular psoriasis. The patient applied clobetasol-17-propionate cream (Betabate(R)) 15∼30 g daily, for 4 months, without a dermatologist`s prescription. After 4 months of application, the following symptoms developed; a moon face; facial flushing; hypertrichosis; central obesity; purple striae; and multiple erythematous scaly annular patches. The development of Cushing syndrome from exogenous corticosteroid treatment was supported by the typical clinical manifestations and the low basal state of the blood cortisol level, which was perhaps due to secondary suppression of the hypothalamic pituitary-adrenal axis. Steroid-containing drugs, especially during childhood, should be used with caution and monitored carefully. (Korean J Dermatol 2007;45(9):947∼950)
정상원(Sang Won Jeong),이상원(Sang Won Lee),윤녕훈(Nyung Hoon Yoon),차승훈(Seung Hoon Cha),박석돈(Seok Don Park) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.2
A 40-year-old female patient, known angiocenteric T-cell lymphoma on nasal cavity, was transfered from the department of hemato-oncology for the evaluation of egg sized pinkish-yellow indurated mass with central necrotic tissue on the left medial elbow. Histopathologic findings revealed angiocentric, angioinvasive, and angiodestructive infiltrate containing atypical lymphocytes. The infiltrative cells were positivly stained with antibody to CD45RO, LCA, but not with antibody CD20. The atypical infiltrated perivascular lymphoid cells were positive to Epstein-Barr virus in situ polymerase chain reaction. She was treated with combined chemotherapy and radiation therapy, but she died due to sepsis. We herein report a rare case of angiocentric T-cell lymphoma on the nasal cavity and skin associated with Epstein-Barr virus. (Korean J Dermatol 2000;38(2):240~244)