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최영일(Youngil Choi),서경원(Kyungwon Seo),윤기영(Kiyoung Yoon),이상호(Sangho Lee),최경현(Kyunghyun Choi) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.75 No.4
Purpose: Despite the reduced incidence and mortality of gastric cancer, this illness still remains the second leading cause of cancer death in Korea. Various adjuvant chemotherapies have been proposed for patients with advanced gastric cancer. Randomized trials comparing chemotherapies with best supportive care have consistently shown that cytotoxic treatment is of some benefit. Nevertheless, there has been no major improvement in the overall prognosis of advanced gastric cancer. Methods: We have examined the chemotherapy sensitivity of advanced gastric cancer specimens by using an ex vivo ATP based chemosensitivity assay (ATP-TCA). A variety of chemotherapeutic agents were tested. The one hundred and forty specimens we tested were from resection specimens. Results: The histological tumor classification, lymphatic invasion, neural invasion and venous invasion affected the chemosensitivity of some drugs. 5-FU was a more potent drug than cisplatin, doxorubicin, iriontecan and methotrexate. The chemosensitivity of differentiated cancer was different compared to that of undifferentiated cancer. Doxorubicin and iriontecan were more effective in poorly differentiated, signet ring cell and diffuse type cancers. The manner of tumor invasion affected the chemosensitivity to some drugs. Conclusison: Further study is necessary to assess the effectiveness of some chemotherapy drugs on advanced gastric cancer, including their effect on tumor recurrence and patient survival.
서경원(Kyungwon Seo),최영일(Youngil Choi),최재영(Jaeyoung Choi),윤기영(Kiyoung Yoon) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.76 No.1
Purpose: Recently, laparoscopic appendectomy (LA) has been widely performed in developed countries. In addition, minimally invasive surgery such as LA is a challenge to surgical residents. The aim of this study is to evaluate learning curve of residents in comparison to that of experienced surgeons. Methods: Fifty cases of LA that were performed by experienced surgeons (group A) and forty-seven cases of LA that were performed by 8 residents (group B) were reviewed retrospectively. Results: Operative time was longer in group B (50.8±12 vs. 82.8±40 min. P<0.001). Hospital days of group B was shorter (4.8±2.4 vs. 3.7±2.1 days P=0.021). No other parameters were statistically significant. In group A, wound infection developed in 1 case. In group B, wound infection developed in 4 cases, intraabdominal abscess in 1, subcutaneous emphysema in 1. Conclusion: Inexperienced surgeons can perform laparoscopic appendectomy easily in the early days of individual laparoscopic training course.