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RISS 인기검색어
- 검색키워드
- 저자 : 오중협 ( Jung Hyub Oh ) (검색결과 42 건)
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이소연,오중협,So Yeon Lee,Jung Hyub Oh 대한안과학회 2011 대한안과학회지 Vol.52 No.2
Purpose: To compare intraocular straylight in normal and cataractous eyes as the morphology and to compare straylight as the result of subjective symptoms in early cataract cases using the C-quant straylight meter, the only tool to measure light scattering in media. Methods: Straylight values were measured in 217 normal eyes and 138 cataractous eyes. Cataractous eyes were classified into posterior subcapsular opacity, anterior subcapsular opacity and nucleosclerosis. Straylight values of each group were measured. The 56 early cataractous eyes were categorized into two groups, depending on the presence of subjective symptoms, and each straylight value was measured. The preoperative and postoperative straylight values of early cataracts were also compared. Results: The mean straylight values of normal and cataractous eyes were 1.34 and 2.46, respectively. The value of posterior subcapsular opacity (2.81) was significantly higher than that of anterior subcapsular opacity (2.33) and nucleosclerosis (1.99). The straylight values of early cataracts were significantly higher in the group with subjective symptoms (2.02) than in the group without subjective symptoms (1.56). The postoperative straylight value decreased to 1.42. Conclusions: The posterior subcapsular cataract showed significantly high intraocular straylight, indicating that light scattering occurred to a greater extent in this group. Light scattering occurred more in early cataractous eyes with subjective symptoms than in eyes without symptoms, and light scattering was reduced after surgery. The C-quant straylight meter, which measures the light scattering in media, can be a useful tool to determine the time of cataract surgery and to evaluate the quality of vision. J Korean Ophthalmol Soc 2011;52(2):182-189
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방사선 조사에 의한 수정체상피세포의 섬유아세포로의 전환분화 억제효과
양석재,이생호,오중협,Seok-Jae Yang,M,D,Saeng-Ho Lee,M,D,Jung-Hyub Oh,M,D 대한안과학회 2005 대한안과학회지 Vol.46 No.11
Purpose: We estimated the effectiveness of radiation on transdifferentiation of the lens epithelial cells into fibroblast. Methods: The morphologic changes and number of fibroblasts were determined using a phase contrast microscope. The proliferation of lens epithelial cells was analyzed by PCNA and BrdU assay in the control group and in the experimental groups exposed to 500, 1000 or 2000 rad of X-ray on the 7th day of culture. Expression of type IV collagen was estimated by Western blot and apoptosis was investigated using TUNEL assay. Results: The number of fibroblast transdifferentiated from lens epithelial cell was 300±1.58 in control group, and 240±1.58, 231.75±4.1E, and 213.50±0.22 in the group exposed to 500 (experimental group I), 1000 (experimental group II), and 2000 rad (experimental group III), respectively, on the 7th day of culture (radiation was decreased in a dose-dependent manner). The index of PCNA and count of BrdU labeling cells were 56±1.58% and 27.6±4.6 in control group; 26±1.56% and 18.4±8.5 in experimental group I; 24±1.60% and 17.2±4.2 in experimental group II; 16±1.58% and 8.6±2.4 in experimental group III, respectively. These results indicated that proliferation of lens epithelial cells was inhibited by radiation in a dose-dependant manner. The Western blot showed that the expression of collagen decreased in experimental groups I and II and markedly decreased in experimental group III, compared with control group. TUNEL showed no differences between the control and experimental groups I and II but showed increased apoptosis in experimental group III. Conclusions: Radiation may inhibit the transdifferentiation of lens epithelial cells into fibroblasts. It would be practicable that radiation suppresses proliferation of lens epithelial cells in posterior capsular opacity.
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