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흰쥐에서 UDCA와 Silymarin을 함유한 간장질환 치료용 의약조성물(DWP305)의 담즙 및 요중 배설
남권호(Kweon Ho Nam),김동오(Dong O Kim),조재열(Jae Youl Cho),염제호(Je Ho Yeom),김영만(Young Man Kim),유은숙(Eun Sook Yoo),유영효(Young Hyo Yu),박명환(Myung Hwan Park) 대한약학회 1994 약학회지 Vol.38 No.6
The pharmacokinetics of DWP305, a new combined preparation for hepatic disorders was examined in rats. DWP305 was composed of ursodeoxycholic acid(UDCA), Cardus marianus extract(silymarin 74.5%), fursulthiamine and riboflavin tetrabutyrate(RTB). Especially, this study was focused on, the possibilities of drug interaction that the administration of DWP305 may affect the oral absorption of each component. After oral administration of DWP305 and each component drug to rats, the biliary excretion of silybin and tauroursodeoxycholic acid(TLJDCA), and the urinary excretion of vitamins were measured by HPLC up to 48 hours. The cumulative amount of TLTDCA or silybin in bile was not significantly different between DWP305 and UDCA/silymarin administered groups at doses of 25 and 100mg/kg. In the case of vitamin study, the urinary thiamine excretion of equivalent molar fursulthiamine administered group was significantly higher than that of thiamine administered group. Urinary riboflavin level of equivalent molar RTB administered group was lower than that of riboflavin administered group, but not significant. These results suggest that the combined preparation may not affect the oral absorption of each component in respect of drug in teraction. Also, fursulthiamine and RTB were more effective in oral absorption than thiamine and riboflavin, respectively.
흰쥐의 급만성궤양모델에서 제산제와 Aceglutamide aluminium의 병용효과
장병수(Byeong Su Jang),염제호(Je Ho Yeom),강진석(Jin Suk Kang),유영효(Young Hyo Yu),박명환(Myung Hwan Park),김운자(Woon Ja Kim),천선아(Sun A Chun),김상미(Sang Mee Kim),이은방(Eun Bang Lee) 대한약학회 1994 약학회지 Vol.38 No.5
The combined products of antacids(AM) composed of aluminium hydroxide, magnesium hydroxide, and simethicone with a ratio bf 1:1:0.1 and aceglutamide aluminium(AGA) were assayed for the antiulcer activity. The effect of the antacids(AM) in concurrent treatment with AGA was studied in acute gastric lesion induced by Shay''s method, stress, ethanol, and indomethacin, in chronic gastric ulcers induced by acetic acid, and in duodenal ulcer induced by mepirizole. In all experimental models, the combined treatment of AM and AGA in the ratio of 2.3:1 showed significant potentiation in inhibition against acute gastric and duodenal ulcer and revealed a significant potentiation of the healing of chronic gastric ulcer.
라니티딘을 함유한 새로운 의약조성물 ( DWP302 ) 의 위장질환 치료효과
유병권(Byoung Kweon Ryu),조태순(Tai Soon Cho),김영만(Young Man Kim),염제호(Je Ho Yeom),유영효(Young Hyo Yu) 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.2
The eight combined products composed of ranitidine·HCI, tripotassium dicitrato bismuthate and sucralfate were prepared with various ratios and studied in therapeutic effects of them on various gastrointestinal diseases, These were induced in rats with the pyrous ligation, ethanol-HCl, acetic acid and cysteamine method, etc. In all experimental setting, the effect of the combined treating was more pronounced than the effect. of each drug alone. Specially, the combined treatment consisted of ranitidine : tripotassium dicitrato bismuthate : sucralfate ratio of 1.5 : 2 : 6 showed the most powerful therapeutic effect on acute gastric ulcer model and revealed a significant acceleration of the healing on chronic gastroduodenal ulcer model. And that, therapeutic doses of ranitidine, tripotassium dicitrato bismuthate and sucralfate given in combination had an additive or, in some case, synergistic effect. From the above results, this combined treatment may useful to heal the gastrointestinal diseases that aren`t cured well by treatment of each them alone.
간장질환 치료용 의약조성물 ( DWP 305 ) 의 이반약리작용
심점순(Jeom Soon Shim),박남준(Nam Jun Park),유영효(Young Hyo Yu),임승욱(Seung Wook Lim),염제호(Je Ho Yeom),김영만(Young Man Kim),장병수(Byeong Su Jang),박명환(Myung Hwon Park),연제덕(Je Duk Yeon),김병오(Byung O Kim),강진석(Jin Seok K 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.2
The general and some pharmacological actions of DWP 305 were investigated in animals and the following results were obtained. In central nervous system, DWP 305 had no effects on the pentobarbital induced anaesthesia, locomotor activity, rotarod test, traction test, analgesic action in mice and body temperature in rat. DWP 305 showed no depressive action on convulsion induced by strychnine, electronic shock and pentylenetetrazole. From these results, DWP 305 was considered to have no pharmacological effect on the central nervous system. Furthermore, DWP 305 had no influences on the normal blood pressure and heart rate. In the isolated ileum of guinea pig, DWP 305 inhibited contrastive effects against the acetylcholine (10^(-6)g/㎖), histamine (10^(-6)g/㎖), 5-hydroxytryptamine (10^(-6)g/㎖) and BaCl₂ (10^(-4)g/㎖) at a concentration of 2.15 X 10^(-4)g/㎖ in bath. In the isolated trachea and vas deference, DWP 305 showed no effect on the contractions produced by histamine and norepinephrine, respectively. DWP 305 showed inhibitory effect on the contractions produced by acetylcholine and oxytocin at a concentration of 2.15 X 10^(-4)g/㎖ on the isolated nonpregnant rat uterus. DWP 305 had no effect on the isolated right atrium of guinea pig, bile excretion urine volume, pH, gastrointestinal motility, gastric secretion and blood aggregation.
위장질환 치료용 의약조성물 ( DWP 301 ) 의 일반약리작용
심점순(Jeon Soon Shim),박남준(Nam Jun Park),유영효(Young Hyo Yu),임승욱(Seung Wook Lim),염제호(Je Ho Yeom),김영만(Young Man Kim),장병수(Byeong Su Jang),연제덕(Je Duk Yeon),김병오(Byung O Kim),강진석(Jin Seok Kang),유은주(Eun Joo Yu) 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.4
The general and some pharmacological actions of DWP 301 were investigated in animals and the following results were obtained. In central nervous system, DWP 301 had no effects on the pentobarbital induced anaesthesia, rotarod test, traction test, analgesic action, anticonvulsant action in mice and body temperature in rat. But DWP 301 showed a little decrease of locomotor activity at a dose of 3,000 mg/kg. From these results, DWP 301 was considered to have little pharmacological effect on the central nervous system. Furthermore, DWP 301 had no influences on the normal blood pressure and heart rate. DWP 301 showed no effect on the isolated guinea pig ileum, trachea, right atrium, and nonpregnant rat uterus. But, in the isolated guinea pig vas deference, DWP 301 had showed inhibitory effect on the contractions produced by norepinephrine. DWP 301 showed rise of gastric juice pH and decrease of urine volume. Also, DWP 301 had no effect on the gastrointestinal motility and blood aggregation. From these results, it is concluded that the general pharmacological effect of DWP 301 are similar to or weaker than M and AGA.
위장질환 치료용 의약조성물 (DWP 302) 의 일반약리작용
김영만,남권호,유영효,임승욱,염제호,장병수,김동오,박명환 한국응용약물학회 1993 Biomolecules & Therapeutics(구 응용약물학회지) Vol.1 No.2
The general and some pharmacological actions of DWP 302 were investigated in animals and the following results were obtained. In central nervous system, DWP 302 had no effects on the pentobarbital induced anaesthesia, locomotor activity, rotarod test, traction test, analgesic action in the mice and body temperature in the rat. DWP 302 showed no depressive action on the convulsion induced by strychnine and electronic shock. From these results, DWP 302 was considered to have no or little pharmacological effect on the central nervous system. Furthermore, DWP 302 had no influences on the normal blood pressure and heart rate. In the isolated ileum of guinea pig, DWP 302 showed neither contractive nor relaxing effects against the acetylcholine (10^(-6) g/ml), histamine (10^(-6) g/ml) and BaCl₂ (10⁴g/ml) at a concentration of 1.9X 10⁴g/ml in bath. But it caused a slight increase in basal tone at a concentration of 6.3 X 10^(-4) g/ml and this effect was inhibited by atropine 10^7 g/ml. In the isolated trachea and vas deference, DWP 302 showed no effect on the contractions produced by histamine and norepinephrine, respectively. And DWP 302 showed no effect on the contractions producd by acetylcholine and oxytocin in the isolated nonpregnant rat uterus. DWP 302 had no effect on bile excretion, urine volume, pH and gastrointestinal motility. But, DWP 302 showed a significant inhibitory effect on gastric secretion in the rat.