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Miniaturized Chromatography에 의한 99mTc - 표지 방사성의약품의 정도 관리
고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),정재민(Jae Min Jeong),염미경(Mi Kyoung Yeom),진광호(Kwang Ho Jin),조규진(Kyu Jin Cho) 대한핵의학회 1990 핵의학 분자영상 Vol.24 No.1
N/A The general use of a number of Tc-99m-labelled compounds makes the need for good routine quality control procedures, especially the labelling efficiency measurements. The purpose of these study were to measure the labelling efficiency of Tc-99m-labelled MDP, DTPA, Tin colloid, and Antimony sulfide colloid using miniaturized paper and instant thin layer chromatography. The chromatographic systems include whatman 3 MM paper and acetone, Gelman ITLC-SG and 0.9% sodium chloride. The chromatographic strips are miniaturized (1×10 cm), marked and numbered. Labelling efficiencies of Tc-99m-labelled DTPA and Tin colloid were above 98.0%. Tc-99m- labelled Antimony sulfide colloid was 90.0%. And labelling efficiency of Tc-99m-labelled MDP was 89.0% Coefficient variance of Tc-99m-labelled MDP, DTPA, Tin colloid, and Antimony sulfide colloid were 5.14%, 2.06%, 1.82% and 4.90%, respectively. We found that this miniaturized chromatographic quality control was simple and reliable.
뇌혈류 평가용 99mTc - HMPAO 합성 및 분포에 관한 연구
고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),조보연(Bo Youn Cho),이범우(Bum Woo Lee),정재민(Jae Min Jeong),염미경(Mi Kyung Yeom),홍미경(Mee Kyoung Hong),최석례(Seok Rye Choi) 대한핵의학회 1990 핵의학 분자영상 Vol.24 No.2
N/A HMPAO was synthesized by two step reaction. d, 1-HMPAO was separated from the racemic product by fractional recrystalization in ethylacetate, and the chemical structure and purity was confirmed by proton NMR spectroscopy. The synthesized d, 1-HMPAO was labeled with Tc- 99m and studied the biodistribution in mice. From the results we could find that liver uptake of synthesized Tc-99m d, 1-HMPAO was higher than that of Amersham kit, but no conspicuous difference was found in brain and other tissues (blood, lung, stomach, intestine, muscle, spleen and kidney).
Iodin-131I OIH와 99mTc - MAG3의 약물동력학 및 체내 분포에 관한 비교 연구
고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),조보연(Bo Youn Cho),이동수(Dong Soo Lee),이범우(Bum Woo Lee),정재민(Jae Min Jeong),염미경(Mi Kyoung Yeom),김문혜(Mun Hye Kim),박경호(Kyung Ho Park),송세흠(Sae Heum 대한핵의학회 1990 핵의학 분자영상 Vol.24 No.1
N/A 99mTc-MAG, was synthesized, and biodistribution and blood clearance rate were compared with those of 131I-OIH in mice and rats respective]y. Finally renal image was obtained from a normal male volunteer before and after prescription of probenecid. The results obtained were as follows: 1) The uptalce of Tc-MAG, by kindey was higher than that of 131I-OIH in mice 10 mins after injection (n=6, p<0.05), but slightly lower uptakes were found in all organs (kindney, blood, stomach, mtestinge and liver) 2 hrs after injection. 2) For ' Tc-MAG, t1/2 a=2.4-+0.0 min, t1/2B=44.3+7.4 min, and blood clearance=3.4+0.5ml/min, and for 131I-OIH t1/2=1.8=0.2 min, t1/2=69.1+9.5 min, and blood clearance=1.3+O.l min were found in rats. 3) From the renogram of normal male volunteer, we could find that tmax=130 sec and t1/2=430sec before probenecid prescriptiori, and tmax 150-170sec and t1/2=810-1,170sec after probenecid prescriprion. From these results we concluded that Tc-MAG, can be used instead of 131I-OIH for obtaining renal irnage.
뇌스캔용 99mTc - HM - PAO의 방사성 동위원소표지에 영향을 미치는 인자에 대한 연구
고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),이동수(Dong Soo Lee),김상은(Sang Eun Kim),염미경(Mi Kyoung Yeom) 대한핵의학회 1991 핵의학 분자영상 Vol.25 No.1
N/A Technetium-99 m-hexamethylpropyleneamine oxime (99mTc-HMPAO) is a neutral-lipophilic chelate which is used for scanning cerebral blood flow. The labeling efftciencies of 99mTc-HM-PAO is known to be sensitive to the amount of pertechnetate added and the quality of the pertechnetate. Because of these factors, the manufacture recornmends that HM-PAO kits be reconstituted with a maximum of 30 mCi pertee.hnetate which was eluted <4 hr earlier from a generator which had been eluted <24 hr previously. So we measured the labelling efficiencies and the decomposition rate constant according to the amount of pertechnetate added, the volume of pertechnette added, and generator in-growth time. We used the 3-system chromatagraphic rnethods (paper & ITLC-SG chrornatography) which analyzed the labelling efficiencies of the 99mTc-HM-PAO. There was no significant difference in labelling efficiencies between variable pertechnetate acitvities added. (39.9 +- 4.9mCi: 87.8 +- 5.1 (%), 60.8 +- 5.0mCi: 90.7 +- 2.2(%), 79.0 +- 6.0mCi: 86.8 +- 3.9 (%), 106.6 +- 11.6mCi: 87.7 +- 1.2 (%), p>0.05) No significant difference in labelling efficiencies were found between pertechnetate of 4 ml and 5 ml. (4 ml: 89.1+3.2 (%), 5 ml: 87.3+4.0 (%), p> 0.05) There was no difference between 1-6 and 10 +-48 hr of generator in-growth time. (1-6 hr: 87 8+ 4.0 (%), 10 +- 48 hr: 89.6+1.6 (%), p>0.05) The mean value of decompositian rate constant was 0.196+ 0.097 (hr-1), and there were no differerce according to the amount of pertecnetate added and the volume of pertecnetate added, (39.9+4.9 mCi: 0.208+0.059 (hr-1), 60.8 +- 5.0 mCi: 0.191 +- 0.100 (hr-1) 79.06.0mCi: 0.192 +- 0.118 (hr-1 ), 106.6 +- 11.6mCi: 0.212 +- 0.030 (hr-1), p>0.05, 4ml: 0.200+0.074 (hr-1), 5mi: 0.193 +- 0.115 (hr-1), p>0.05) In the case of using the first eluate, the labeliing efficiency of 99mTc-HM-PAO was 82.1%.. These data suggest that there were no significant aiteration in labelling efficiency of 99m Tc-HM- PAO aecording to the considerable range of pertechnetate activities and volume added, and generator in-growth time. Also, it was shown that one vial of HM-PAO kit supplied the Tc-HM-PAO which was used for 3-4 patients.