http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Murine B16 Melanoma 세포에서 저산소 상태가 멜라닌색소 합성에 미치는 영향
송영길 ( Young Gil Song ),양정예 ( Jeong Yeh Yang ),구정현 ( Jeung Hyun Koo ),윤하용 ( Ha Yong Yoon ),이승용 ( Seung Yong Lee ),윤석권 ( Seok Kweon Yun ),박병현 ( Byung Hyun Park ),김한욱 ( Han Uk Kim ),박진우 ( Jin Woo Park ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.4
Background: Numerous reports suggest the role of oxygen in melanogenesis. However, little has been reported on the effect of a hypoxic environment on cellular melanogenesis. Objective: The effect of low oxygen tension on cellular melanogenesis was investigated in B16 murine melanoma cells. Methods: Using cells cultured under an ambient (21% O2) or hypoxic (5% O2) condition, melanin content and tyrosinase activity were measured spectrophotometrically. The expression of tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 were analyzed by RT-PCR and Western blot. Results: Culture of cells under hypoxic conditions caused significant inhibition of isobutylmethylxanthine (IBMX)-induced increase of melanin content. No cytotoxicity was observed during the hypoxic culture periods. Decreased melanin content occurred through the decrease of tyrosinase protein and activity (p<0.01). The mRNA levels of tyrosinase and TRP-2 were also decreased by hypoxia, while that of TRP-1 was unchanged. Similar inhibitions of melanin content and tyrosinase activity were observed in the cells stimulated with dibutyryl-cAMP. Conclusion: IBMX-induced melanogenesis in B16 cells was significantly inhibited under hypoxic culture conditions, suggesting the important role of oxygen tension in cellular melanogenesis. (Korean J Dermatol 2007;45(4):332~337)