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        HLA and Disease Associations in Koreans

        안스데반,김태규,최희백 대한면역학회 2011 Immune Network Vol.11 No.6

        The human leukocyte antigen (HLA), the major histocompatibility complex (MHC) in humans has been known to reside on chromosome 6 and encodes cell-surface antigen-presenting proteins and many other proteins related to immune system function. The HLA is highly polymorphic and the most genetically variable coding loci in humans. In addition to a critical role in transplantation medicine, HLA and disease associations have been widely studied across the populations worldwide and are found to be important in prediction of disease susceptibility, resistance and of evolutionary maintenance of genetic diversity. Because recently developed molecular based HLA typing has several advantages like improved specimen stability and increased resolution of HLA types,the association between HLA alleles and a given disease could be more accurately quantified. Here, in this review, we have collected HLA association data on some autoimmune diseases, infectious diseases, cancers, drug responsiveness and other diseases with unknown etiology in Koreans and attempt to summarize some remarkable HLA alleles related with specific diseases.

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        Cytomegalovirus-Specific Immunotherapy for Glioblastoma Treatments

        재현,안스데반,Christopher Shin,Yeo Song Kim,박재성,전신수 대한뇌종양학회 2022 Brain Tumor Research and Treatment Vol.10 No.3

        Over the last two decades, numerous studies have investigated the presence of human cytomegalovi- rus (CMV) within glioblastoma or gliomas; however, the results are severely conflicting. While a few re- searchers have suggested the potential benefits of cytotoxic T lymphocyte or dendritic cell-based vac- cines for recurrent or newly diagnosed glioblastoma patients, several studies did not at all agree with the existence of CMV in glioblastoma cells. In this review, we summarized the conflicting results and issues about the detection of CMV in glioblastoma or glioma patients. We also provided the clinical data of published and unpublished clinical trials using CMV-specific immunotherapy for glioblastomas.

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