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돼지에 있어 인공혈관으로 대정맥 재건을 통한 자가 부분 간이식 동물 실험 모델
서형일(Hyung-Il Seo),심문섭(Mun Sup Sim),김동헌(Dong-Heon Kim),전태용(Tae Yong Jeon),조홍재(Hong-Jae Jo),권재영(Jae Young Kwon),김해규(Hae Kyu Kim),김해영(Hae Young Kim) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.74 No.4
Purpose: Experimental animal models are useful training methods for liver transplantation, despite of ethical issues. The aims of this study are to examine the technical feasibility of living donor liver transplantation in pigs and to address the ethical problems. Methods: Eight pigs were used in this experiment. The pig liver was divided via a left hemi-hepatectomy without inflow occlusion. The GORE-TEX<SUP>R</SUP> Vascular Graft was used as a replacement for the inferior vena cava during the graft. After the bench technique, the remnant right lobe of the pig was removed. During the anhepatic phase, an abdominal aortic clamp in combination with general hypothermia was applied, instead of using a conventional bypass procedure. Results: Anhepatic time was 41.3±7.0 min and cold ischemic time was 200.3±29.4 min. The 1<SUP>st</SUP>, 4<SUP>th</SUP>, and 8<SUP>th</SUP> pig died because of declamping shock and arrhythmia on releasing the abdominal aortic clamp. Three pigs had five postoperative complications: pneumonia, gastrointestinal bleeding, IVC thrombosis, portal vein thrombosis, and bile duct stricture. The 6th pig received a hepaticojejunostomy due to stricture of the anastomosis site at 37 days after transplantation. Conclusion: Pigs are economically and ethically more convenient compared to primate models. For auto-liver transplantation, no immunotherapy was needed. The pigs lived relatively long, allowing operative faults to be detected and studied. This experimental model will be useful training for living donor liver transplantation.