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LPS로 자극한 RAW264.7 세포에서 강활 추출물의 염증성세포활성물질의 억제효과
박희제 ( Hee Je Park ),배기상 ( Gi Sang Bae ),김도윤 ( Do Yun Kim ),서상완 ( Sang Wan Seo ),박경배 ( Kyung Bae Park ),김병진 ( Byung Jin Kim ),송제문 ( Je Moon Song ),이경용 ( Kyung Yong Lee ),나철 ( Chul Na ),신병철 ( Byung Chul 대한본초학회 2008 大韓本草學會誌 Vol.23 No.3
Objectives: The present study was designed to investigate whether Ostericum koreanum (OK) could regulate lipopolysaccharide (LPS)-induced inflammatory response in vitro and in vivo. Methods: To evaluate of anti-inflammatory effect of OK, we examined Nitric oxide (NO), proinflammatory cytokines production in LPS-stimulated RAW264.7 cells. Furthermore, we checked molecular mechanism especially in the phosphorylation of mitogen-activated protein kinases (MAPKs) and the degradation of inhibitory kappa B a (Ik-Bα) using western blot and also investigated survival of mice in LPS-mediated endotoxin shock. Results: 1. Extract from OK itself have weak cytotoxic effect on RAW264.7 cells. Extract from OK inhibited LPS-induced NO, tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and IL-10 production in RAW264.7 cells. 2. OK inhibited the phosphorylation of MAPKs, such as p38, extracelluar signal-regulated kinase (ERK1/2) and c-Jun NH2-terminal kinase (JNK) and also the degradation of Iκ-Bα in the LPS-stimulated RAW264.7 cells 3. OK did not inhibit LPS-induced endotoxin shock. Conclusions: OK down-regulated LPS-induced NO and cytokines production through suppressing activation of MAPKs and degradation of Ik-Bα. Our results suggested that OK may be a beneficial drug against inflammatory diseases.