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        반사 분광광도법 ( Reflectance spectrophotometry ) 을 이용한 화염상 모반의 색소 레이저 치료 효과의 평가

        박기범 ( Ki Beom Park ),손일영 ( Il Young Son ),양성규 ( Sung Kyu Yang ),이일수 ( Eil Soo Lee ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.5

        Background: At present, flashlamp-pumped pulsed dye lasers are treatment of choice for the treatment of congenital capillary malformations like nevus flammeus. Clinical methods have been generally used to evaluate their effectiveness in many papers. Objective: To evaluate the effectiveness of the laser therapy in nevus flammeus patients, we used reflectance spectrophotometry as a supportive objective method in addition to the clinical evaluation. Methods: Thirty-two patients with definite nevus flammeus skin lesion, mainly on head and neck, were treated with flashlamp-pumped pulsed dye laser(SPTL-1b) at 8 week interval. Patients without previous treatment and the others with previous treatments were grouped separately to compare the influence of previous treatment to laser therapy. Erythema/Melanin indices were measured before and after laser therapy in both normal and lesional skin. Based on these indices, relative blanching effect were calculated. Results: Clinically, they showed 58.6% improvement in their skin color in average and Erythema/Melanin indices measured on normal skins were 13.09+3.91 a.u. and 34.65+2.82 a.u.. Erythema indices measured on lesional skins were 26.07+10.26 a.u. and 20.73+8.81 a.u. in non-treated group and 24.53+6.14 a.u. and 21.18+5.47 a.u. in pre-treated group, alternatively. Relative blanching effect in both groups were calculated as 35.9% and 31.6%, meaning no significant difference(p>0.3). Clinical evaluation and relative blanching effect showed good correlation(r=0. 691). Conclusion: Reflectance spectrophotometry can be useful in evaluating successful laser treatments in nevus flammeus patients. Reflectance measurements, an objective estimate of blanching, correlate well with the clinical results, and are helpful in monitoring and predicting the therapeutic outcome in dye laser treated patients. (Kor J Dermatol 1996;34(5): 747-752)

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        국소적으로 과립세포의 소견을 보이는 피부섬유종 1예

        김희중,박광영,이일수,손일영,조광현 대한피부과학회 1999 대한피부과학회지 Vol.37 No.6

        Dermatofibroma with granular cells is composed mainly of spindle shaped cells mixed with in-conspicuous foamy cells that contain granular cytoplasm. We present a case of dermatofibroma with granular cells in a 36-year-old male who visited our clinic to evaluate a slow-growing nodule on the medial side of the left lawer leg. He have had the nodule for five years and sometimes felt an itching sensation. Biopsy of the nodule identified a dermal nodular tumor showing cellular spindle cell proliferation admixed with peripheral foamy histiocytes. With the immunohistochemical staining, the granular cell was positive for alpha-1-antitrypsin and CD68, and negative for S-100. A few electron-dense granules were seen in the cytoplasm on the electronmicroscopic study. These results suggested that the granular cells originated from histiocytes.

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        하순에 발생한 진피내 모반 1예

        박경호,이일수,민형근,손일영 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.2

        We report a case of intradermal nevus in a 52-year-old female patient, who presented with asymptomatic, solitary papule, which had been on the site for years as a macule on the center of the lower lip, which is a rare site for intradermal nevus. The skin biopsy revealed the upper dermis containing nests and cords of nevus cell without junctional activity. The skin lesion was totally removed by surgical excision on biopsy.

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