단애양 피낭성 신경종 ( Palisaded , Encapsulated neuroma )

홍석진 ( Seok Jin Hong ),김삼형 ( Sam Hyeong Kim ),강훈 ( Hoon Kang ),손숙자 ( Sook Ja Son ),장희진 ( Hee Jin Jang ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.1

Palisaded, encapsulated neuroma is characterized clinically by a solitary, slowly-growing and dome-shaped papule or nodule, usually accompanied by telangiectasia on the surface, and histopathologically by an encapsulated nodule in the dermis and the palisading arrangement of nuclei. A 57-year-old female patient presented with a 1cm-sized, solitary nodule on the right ala nasi which had been present for about 5 years. The nodule had a tendency to slow growth and it became a polypoid nodule. Telangiectasia was shown on the surface of the lesion. Histopathlogical findings showed a well-defined and encapsulated nodule in the dermis, composed of spindle cells with basophilic and plump nuclei in a palisading fashion. On immunohistochemical staining, the tumor cells of the nodule were positive for S-100 protein, while the capsule of the nodule was negative for S-100 protein. Epithelial membrane antigens were focally positive only on the capsule of the nodule. We report herein a case of palisaded, encapsulated neuroma, one case of which has been reported in Korea. (Korean J Dermatol 1998;36(1): 173-176)

윤상 육아종의 임상 및 병리조직학적 관찰

홍석진(Seok Jin Hong),김동준(Dong Jun Kim),손숙자(Sook Ja Son),강훈(Hoon Kang) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.8

윤상 육아종은 임상적으로 크게 전신형과 국소형으로 나뉘어진다. 국소형은 주로 결절이나 원형의 모양을 띄면서 손이나 손가락, 손목, 발목 등에 호발하며, 진행하여 융합하면 원형의 판을 형성하거나 융기된 큰 종괴모양을 보이기도 한다. 전신형은 국소형과 유사하지만 중년이상의 여자에서 햇빛에 노출된 부위에 잘 발생하고 당뇨와 연관되어 발생하기도 한다. 한편 조직학적 소견으로 변성된 교원질 둘레로 단애양의 단핵구 침윤이 특징적 소견이지만 이러한 특징적 소견이 없는 경우도 흔하게 볼 수 있다. 이와 같이 윤상 육아종은 그 임상양상과 병리조직학적 소견이 다양하게 나타날 수 있으나 국내에서 15예의 증례보고만 있을 뿐 임상 및 병리조직학적 소견에 대한 전반적인 연구가 없어 자자들은 윤상 육아종의 임상 및 병리조직학적 소견들을 문헌고찰과 함께 보고하고자 하였다. Background: Granuloma annulare is a chronic skin disease of unknown origin, that can present itself with diverse clinical and histopathologic findings. But no clinicopathological studies has been reported yet in Korea. Objective: Our purpose was to investigate the clinicopathological findings of each type of granuloma annulare. Methods:We observed twenty two cases of granuloma annulare and examined their clinical manifestations and histopathological findings. Results: The incidence showed a bimodal peak between 3 to 4 years and 49 to 51 years in age and females were affected twice as much as males. The lesions are commonly located on the distal protion of the extremities. In histopathologic findings, perforating type was observed in 13.6% and subcutaneous type in 18.2%. In collagen alteration, fragmentation and hyalinization were observed in 72.7% and 81.8% respectively. Most infiltrated cells were epithelioid cells. In vascular changes, endothelial swelling and occlusion of vessels were common findings and vasculitis was shown in 36.4%. Conclusion:There were not epidemiologic differences from the reported studies in western patients. But the clinical manifestation and the histopathologic findings were so varied that differential diagnosis is important in diagnosis of granuloma annulare. Immunological and Immunohistochemical studies may be necessary for differential diagnosis and elucidating pathogenesis of granuloma annulare.(Korean J Dermatol 1999;37(8):1029~1037)

대상 포진 수막뇌염

전형진 ( Hyeong Jin Chon ),홍석진 ( Seok Jin Hong ),강훈 ( Hoon Kang ),손숙자 ( Sook Ja Son ),정근호 ( Keun Ho Jeong ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.4

비특이적 임상 소견을 보인 Gianotti - Crosti 증후군

홍석진,김삼형,강훈,손숙자 ( Seok Jin Hong,Sam Hyeong Kim,Hoon Kang,Sook Ja Son ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.4

We report herein a case of Gianotti-Crosti syndrome showing unusual features. A 12-month-old male patient presented with papular skin lesions on his face and papulovesicular skin lesions on the trunk, upper and lower extremities, which were distributed symmetrically. Three days before the skin eruptions, he had been immunized with a measles vaccination. Serologically, antigens of the type B hepatitis virus and antibodies to coxsackie virus B-4, Epstein-Barr virus, and varicella-zoster virus were all negative and antibodies to the measles virus (IgG, IgM) and the type B hepatitis virus were positive. After conservative treatment the skin lesions subsided with exfoliation within 4 weeks. An association with the measles vaccination and the initial papulovesicular skin lesions are considered as peculiar features of this case. (Kor J Dermatol 1997;35(4): 830-834)

비전형적인 임상 양상을 보인 호산구성 농포성 모낭염 4예

홍석진,김삼형,강훈,손숙자 ( Seok Jin Hong,Sam Hyeong Kim,Hoon Kang,Sook Ja Son ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.6

We report three cases of u.iiusual eosinophilic pustular folliculit is whose initial manifestation is indurated plaque rather than papule and pustule and one case of eosinophilic pustular folliculitis was found in an infant. None of the adult patients in these cases complained of any suhjective syrnptoms other t.han the skin lesion, but an itching sensation might be present in the case of the infant. In laborat ory test, eos nophilia was observed in only one case and any other abnormal results were not observed. In all cases, histopathologic study revealed numerous eosinophilic infil tration around the follicles ext.i nding to the periappendageal and perivacscular area, that is consistent with the finfings of eosinophilic pustuar folliculitis. All adult patients relatively responded well to dapsone and topical stroid and the infant patient resporided well to topical steroids, But they had a chronic course with remission and exacerhation (Korean J Dermatol 1997;35(6): 1244-1249)

대상포진의 임상 및 병리조직학적 연구

박지수(Ji Soo Park),홍석진(Seok Jin Hong),손숙자(Sook Ja Son) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.11

N/A Background: Herpes zoster is a relatively common disease and there have been several reports on clinical study of herpes zoster. However no clinicopathological study has been reported yet in Korea. Objective : The purpose of this study is to investigate the clinical and pathological findings of herpes zoster. Methods : We performed a retrospective study of eighty patients with herpes zoster in whom skin biopsies were done from 1995 through 1999, We obtained the clinical features from record reviews and reevaluated biopsy specimen of each patient. Results : 1. Herpes zoster was most frequently observed in 6th decade(40.0%). There was no sexual difference. 2. The dermatome of thoracic nerve was most frequently involved(55.0%), and followed by the dermatomes of cervical nerve(28.7%), lumbar nerve(16.2%) and trigerminal nerve(8.7%). 3. Postherpetic neuralgia was the most frequent complication of herpes zoster and was noted in 22 of the total cases(27.5%). 4. Histologically, in the epidermis, ballooning degeneration was observed in 97.5%, and reticular degeneration in 81.2%. Multinuclear giant cells and inclusion bodies were observed in 42.5% and 32.5%, respectively. In the dermis, herpetic folliculitis was observed in 28.7% and syringitis in 3.7%. Leukocytoclastic vasculitis was observed in 22.5%. Conclusion: The results of clinical aspects were similar to those of previous studies. Histopathologically, most of the cases showed typical viral changes in epidermis and in some cases, herpetic folliculitis and syringitis were noted.

Pseudallescheria boydii에 의한 진균종

김삼형 ( Sam Hyeong Kim ),홍석진 ( Seok Jin Hong ),강훈 ( Hoon Kang ),손숙자 ( Sook Ja Son ),송계용 ( Kyae Yong Song ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.2

Pseudallescheria (P.) boydii is a true fungus that is ubiquitous in nature, and has a world-wide distribution. It has been isolated from soil, plant debris, polluted water and sewage. Infection may occur via direct inoculation or inhalation, and usually affects the extremities. It is a common cause of mycetoma characterized by tumefaction, draining sinuses and grains. It has polymorphism due to a complicated life cycle which undergoes teleomorph as well as anamorph stages. Cleistothecia, ascocarp and ascospore may be seen during the teleomorph stages, whereas scedosporium and graphium type may be seen during the anamorph stages. We report a case of P. boydii mycetoma occurring in a 69-year old male. He had multiple nodules with a discharging fistula on a dark red plaque at the dorsum of the right forearm. Cultural isolation for definitive diagnosis showed typical P. boydii. The lesion responded well to daily itraconazole. (Korean J Dermatol 1998;36(2): 341-345)

성인 T - 세포 백혈병 / 림프종 ( Adult T - cell leukemia / lymphoma ) 1 예

류지훈(Ji Hun Ryu),박지수(Ji Soo Park),홍석진(Seok Jin Hong),홍석일(Seok Il Hong),손숙자(Sook Ja Son),서창인(Chang In Suh) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.3

Adult T-cell leukemia/lymphoma (ATLL) is an often aggressive and fatal malignancy of mature CD4+ T lymphocytes, characterized by leukemia, lymphadenopathy, hypercalcemia and lytic bone lesions. Diagnosis of ATLL is based cm abnormal T lymphocytes in the peripheral blood and histologically and cytologically proven lymphoid malignancy with T cell surface antigens. Anti-HTLV-I serum antibodies and demonstration of clonality to HTLV-I proviral DNA are included. We report a case of ATLL in a 64-year-old man who had a painful nodule on the right cheek and multiple scattered papules and nodules on the trunk for 2 months. He had multiple cervical and axillary lymph node enlargements and hepatosplenomegaly. On laboratory finding peripheral leukocytes count was 33,400/mm3 with 63% atypical lymphocytes. Clover-shaped lyrnphocytes with multilobulated nuclei were found in peripheral blood and bone marrow. Histologic findings showed dense bandlike infiltrations of atypical lymphocytes in the dermis with angiocentricity. The surface phenotype of these abnormal cells were CD2+, CD3+, CD4+, CD30+ and HLA-DR+ and HTLV-I specific antibodies were found. (Korean J Dermatol 2002; 40(3): 295~299)

다양한 표피 부속기 종양을 동반한 피지선 모반 1예

강훈,손숙자,홍석진,전형진 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.1

We report a case of nevus sebaceus of Jadassohn in a 31-year-old female associated with various epidermal appendage tumors, such as syringocystadenoma papilliferum, sebaceus adenoma and eccrine hidrocystoma. We supposed that the multiple lesions seem to support the concept of nevus sebaceus arising from the pluripotential primary epithelial germ.

사마귀양 이각화종 1예

강훈,손숙자,홍석진,전형진 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.5

We report a case of warty dyskeratoma in a 65-year-old man. He had a asymptomatic solitary 1 x 1 cm sized, round, light-brownish colored, centrally depressed nodule on the right forehead for several yearss. Histopathological findings showed two large cup-shaped keratin-filled invagination of acanthotic epidermis, suprabasal cleft formation with corps ronds, grains and numerous villi at the lower portion of the invagination, the characteristic features of warty dyskeratoma.