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성종화,정재호,전시영,황의기 대한이비인후과학회 2002 대한이비인후과학회지 두경부외과학 Vol.45 No.7
Background and Objectives:We can evaluate nasal hyperreactivity with histamine challenge test (HCT) or metacholine s technique to assess nasal hyperreactivity. The basic concept of the test is that filter paper in the nose acts as a mechanical stimulus to the nasal mucosa, and causes nasal secretion, which is absorbed in the filter paper. The aim of this study was to present filter paper test (FPT) as an objective assesment of nasal hyperreactivity in allergic patients. We compared the sen-sitivity and the specificity of FPT with HCT, and also evaluated the validity of FPT in assessing the changes of nasal hyper-reactivity. Subjects and Method:For FPT, a folded strip of filter paper in 50× 6 mm was placed between the septum and lution (1 mg/ml) was placed on the anterior end of the inferior turbinate, and the number of sneezing was counted per minute. Twenty nine patients with allergic rhinitis and hyperreactive nasal symptoms and 20 normal subjects were included in the study. Fourteen out of the 29 hyperreactive and allergic rhinitis patients were subjected to the evaluation of changes in the amount of nasal secretion. Results:For FPT, sensitivity was 65.5% and specificity was 95% , whereas for HCT, the sensitivity was 69% and specificity was 95% . After systemic steroid treatment, the amount of nasal secretion was decreased significantly. Conclusion:FPT showed almost the same sensitivity and the specificity compared to HCT, and appeared to be a valid test to assess the nasal hyperreactivity. These findings imply that FPT is technically easy and reliable, and a valid test to assess nasal hyperreactivity in allergic patients. (Korean J Otolaryngol 2002;45:682-6)