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장기간의 크레아틴 섭취가 역도선수 신장 기능에 미치는 영향
선주상 ( Zhou Xiang Shan ),안효작 ( Hyo Jak Ahn ),염동철 ( Dong Cheol Yeom ),김창근 ( Chang Keun Kim ) 한국체육대학교 체육과학연구소 2013 스포츠사이언스 Vol.31 No.1
The aim of the present study was to investigate the effect of a long term creatine supplementation on renal function in weight lifters. Fifty seven weight lifters who have been supplemented creatine was participated in the experiment, and divided into four groups of under 1 yr (n=10), 1 to 3 yrs (n=15), 3 to 5 yrs (n=16), and over 5 yrs (n=16) by the period of creatine intake. Serum and urine creatine, creatinine, uric acid, and cystatin-C were analysed to evaluate renal function. There was no significant differences among the groups, not only by the measurement of serum creatine, creatinine, uric acid, cystatin- C, but also in urine as well. All measured valuables to evaluate renal function maintained normal concentration either in blood or in urine. But urine creatinine and uric acid level were maintained higher than normal concentration, and GFR level in serum was lower than normal level in all groups. In summary, there were no difference among the different durations of creatine supplementation of under one year to more than five years in the parameters measured in serum and urine. However urine creatinine and uric acid level were maintained slightly higher, and GFR level in serum was slightly lower in all groups. Therefore, it is highly recommended further research to confirm these findings in the future.
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권혁용 ( He Long Quan ),선주상 ( Zhou Xiang Shan ),김영선 ( Young Seon Kim ),최재근 ( Jae Keun Choi ),김창근 ( Chang Keun Kim ) 한국체육대학교 체육과학연구소 2013 스포츠사이언스 Vol.31 No.1
Hypoxic environment can be defined as a complex phenomenon with a decreased partial pressure of oxygenunder the 150mmHg during inhalation by a decreased atmospheric pressure. A various investigations which is related to a decrease oxygen tension or altitude environment has been performed in the field of life science. It has been intensively studied the relationship between hypoxia and exercise performance to prepare for Mexico Olympic Games, and ahs been performed many studies about the adaptation to hypoxia to prove the possibility of improvement of exercise performance. In recent years athletes who has been training from young age at a mild altitude (2000-3000m a.s.l.) has been leading international competitions of middle and long distance run, including marathon run. However, there has been debated whether altitude environment can modulate bodily function, especially exercise performance. Up to today various attempts has been considered to acclimatize to hypoxia efficiently, because athletes may not perform their maximal capacity during early stage of altitude adaptation, and thus recently new technique has developed to control oxygen content at sea level, in terms of normobaric hypoxia. Hypoxic facility can allow the athletes living in normobaric hypoxia and training in normobaric normoxic environment. Various investigations has been performed not only regarding on exercise performance but also on metabolic syndromes according to different response body function to hypoxia compared to normoxia, especially hypoxia has an important role in glucose and fat metabolism. Hypoxia and exercise induce to increase insulin sensitivity and epinephrine to decrease in muscle glycogen, and also does an increase in the expression of hypoxia-inducible factor-1a and leptin concentration to reduce body weight in voluntarily. Therefore, it is important to unravel the mechanism of body weight reduction by the exposure in hypoxic environment and thus may be suggested as a possible countermeasure to the obesity epidemics. Therefore, hypoxia and its related recent studies of exercise performance and metabolic syndromes, including obesity, glucose and fat metabolism will be included in this review.
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노화와 일회 지구성 운동이 골격근 내 mTOR, 4E-BP1, p70S6K 및 AMPK 발현에 미치는 영향
어수주(Eo Su-Ju),권형태(Kwon Hyeong-Tae),선주상(Shan Zhou-Xiang),채정훈(Chae Jung-Hun),김효식(Kim Hyo-Sik),손희정(Son Hui-Jung),김효정(Kim Hyo-Iung),김창근(Kim Chang-Keun) 한국체육과학회 2011 한국체육과학회지 Vol.20 No.3
We determined acute endurance exercise on mTOR signaling responses in aging skeletal muscle(soleus; SOL, extensor digitorium longus; EDL). Total 32 Sprague-Dawley rats were divided into two groups by age; young group(YG; 20wk; n=16) or old group(OG; 72wk; n=16). Each experimental group was further allocated two subgroups; Exercise(EX; n=8), Control(CON; n=8) group. All animals in exercise group performed one bout of 3hr endurance swimming exercise (30min×6bouts). The phosphorylation of mammalian target of rapamycin(mTOR) and p70 ribosomal S6 kinase(p70S6K) were significantly increased in 20wk(YG) soleus (p<.05). However, the phosphorylation of mTOR and eukaryotic initiation of factor 4E binding protein 1(4EBP1) were significantly decreased in 72wk(OG) muscles(p<.05) after endurance acute swimming exercise. The phosphorylation state of AMPK was significantly increased in 20wk(YG) muscles(p<.05) and 72wk soleus(p<.01) after exercise. The results suggest that a bout endurance exercise was increased AMPK activity but inhibited mTOR and 4E-BP1 phosphorylation in aging slow-twitch muscle.
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고강도의 지구성 운동 수행에 의한 근비대 신호 단백질 mTOR, p70S6K, 4E-BP1 및 AMPK의 발현 변화
한광호(Han Gwang-Ho),권형태(Kwon Hyeong-Tae),손희정(Son Hee-Jeong),채정훈(Chai Jung-Hoon),선주상(Shan Zhou-Xiang),김효정(Kim Hyo-Jeong),김창근(Kim Chang-Keun) 한국체육과학회 2011 한국체육과학회지 Vol.20 No.3
The present study was performed to investigate the effect of endurance running on muscle protein synthesis. Male Sprague-Dawley rats(n = 49) were randomly assigned to the time course of the treadmill running (VO₂max 75-80%, 1hr). Muscle samples were obtained before and recovery period of the exercise (immediately, 30 min, 1hr, 2hr, 3hr and 6hr from the running) at the soleus muscle for the determination of mammalian target of rapamycin (mTOR), p70S6 kinase (p70S6k), eukaryotic initiation factor (eIF) 4E-binding protein (4E-BP1) and AMPK phosphorylation. Endurance exercise generated a significant increase in mTOR phosphorylation immediately after exercise and the phosphorylation maintained up to 6hr of recovery (∼90%, p=.024). In addition, 4EBP1 phosphorylation was significantly increased at the immediately after exercise and decreased up to an hour recovery. However, 4EBP1 was resumed to increase for 2-3hrs during recovery (∼48%, p=.05). However, Phosphorylation of p70S6K was elevated above rest level throughout the 6hrs recovery and reached peak at 6hr recovery (303%, p=.001). On the other hand, Phospho-AMPK (Thr172) was increased from 30min to 3hr of recovery (p<.05). These results clearly demonstrate that intensitive endurance running result in significant differences in protein signaling of muscle protein synthesis.
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