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모살용접을 사용한 각형강관기둥-H형강보 모멘트 접합에 관한 실험적 연구
정진안(Chung Jin-An),서성연(Suh Sung-Yeon),최성모(Choi Sung-Mo) 대한건축학회 2004 大韓建築學會論文集 : 構造系 Vol.20 No.5
In seismically active regions such as Japan, most of steel structures are constructed using moment resisting frames<br/> that are composed of square tubular section columns and H-shaped beams. Through-type diaphragm was widely used in<br/> the case of beam-to-box column connection in spite of theirs complexity of fabrication. The Hyogoken-Nanbu earthquake<br/> in 1995, however, caused very severe damage to through-type diaphragm. Most of through-type diaphragm connections<br/> were damaged in both welding part of beams and columns. On the other hand, outer diaphragm have merit of reducing<br/> the process of fabrication, because it is not need the cutting of the column to connect, and of convince of assuring<br/> concrete compactness of concrete filled-steel tubular columns.<br/> This study focuses on the development of a new connection method of H-shaped beam-to-square tubular column<br/> connections. The connection method using external stiffener of outer diaphragm was presented. A specific type of<br/> H-shaped beam-to-square tubular column connections with vertical stiffener has been experimentally studied under cyclic<br/> loading. Six test specimens were tested at the structural Laboratory of Kyushu University. The structural performance of<br/> the test specimens is discussed well as resulting conclusions.
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약물유해반응 이후 처방의 변경 유형과 치료 결과: Lamotrigine 관련 사례 분석
강정은 ( Jeong Eun Kang ),이경훈 ( Kyeong Hun Lee ),서비취 ( Bi Chwi Seo ),임정미 ( Jung Mi Lim ),서성연 ( Sung Yeon Suh ),조윤숙 ( Yoon Sook Cho ),서동인 ( Dong In Suh ) 대한천식알레르기학회 2023 Allergy Asthma & Respiratory Disease Vol.11 No.2
Purpose: This study aimed to describe the desperate situation where the clinician should make decisions to further manage patients having experienced adverse drug reaction (ADR) to lamotrigine that is indicated to not easily controlled neuropsychiatric diseases. Methods: A descriptive analysis was done by thoroughly reviewing medical records of patients who were reported to have ADR to lamotrigine in a regional drug-safety center between 2010 and 2018. Results: Eighty-four cases of lamotrigine-related ADRs occurred in 80 patients. Skin lesions were most commonly observed in 70 cases (83.3%) and 14 cases (16.7%) had severe ADRs. Sixty-three subjects (78.8%) discontinued lamotrigine, while 17 (21.3%) continued it. At the time of discontinuation, 30.0% were prescribed aromatic antiepileptic drugs. Among 4 subjects who were eventually prescribed lamotrigine again after a period of discontinuation, 3 (75.0%) experienced its recurrence. Among patients who had taken alternative medications, the incidence of ADRs was higher in those being prescribed aromatic antiepileptic drugs than in the others being pre scribed other than aromatic antiepileptic drugs (P=0.013). Regarding the control of underlying diseases, as many as 65 (86.7%) and 68 (90.7%) failed to reach maintaining the resolved state from 6 months and 12 months after the substitution, respectively. Conclusion: Patients can be easily trapped between the recurrence of ADRs and the treatment failure to a certain drug like lamotrig ine, in which we can hardly find a reasonable alternative to manage them. (Allergy Asthma Respir Dis 2023;11:72-76)
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