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Acetolactate synthase에 대한 고효율 활성 측정방법 및 신규 저해제 탐색
박상희(S.H. Park),황인택(I.T. Hwang),이관휘(K.H. Lee),최정섭(J.S. Choi),변종영(J.Y. Pyon),조광연(K.Y. Cho) 한국농약과학회 2001 농약과학회지 Vol.5 No.3
This study was conducted to develop a high throughput system for screening acetolactate synthase (AlS) inhibitors, and to detect basic mother molecules for developing new novel herbicide candidates. The high throughput screening (HIS) method using 96-well plate and microplate reader was developed. This method is 8 times more effective than basic technique in one cycle per person. Futhermore, considering for less than 1/10 volume of materials required for ALS test and enzyme kinetics with 16 times faster speed compared to those of former procedure, this HIS method has more than 100 times higher efficacy than basic system in a consecutive procedure. We discovered 11 new ALS inhibitors such as 2-oxoglutaric acid, aminooxyacetic acid, azelaic acid, citric acid, cyanuric fluoride, itaconic acid, malonic acid, niclosamide, oxalic acid, glyoxylic acid, and suramin from 107 commercial plant-specific inhibitors using this technique. We hope these results might be useful to discover lead compounds for developing new novel herbicide candidate.