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자간전증 임산부의 태반조직에서 Nuclear Factor-κB의 발현
유승철 ( Seung Chul Yoo ),변영자 ( Young Ji Byun ),양정인 ( Jeong In Yang ),주희재 ( Hee Jae Joo ),김행수 ( Haeng Soo Kim ),유희석 ( Hee Sug Ryu ) 대한주산의학회 2004 Perinatology Vol.15 No.1
Objective : The aim of this study is to ascertain the differences in NF-κB (Nuclear Factor-kappa B : p50) activity between the placental tissues of preeclampsia and normal pregnancy, and to certify that the circulating lipid peroxides is increased in preeclamptic women. Methods : Placental tissues were obtained from preeclamptic (n=33) and normal pregnancies (n=21) with no other medico-surgical illness or obstetric complications, delivered by cesarean section without labor. The activities of NF-κB and IκBα (Inhibitory factor kappaBα) on syncytiotrophoblast, cytotrophoblast, endothelium, extravillous cytotrophoblast, and decidua were separately measured by immunohistochemical staining using tissue microarray technique. Malondialdehyde assay was used to evaluate the oxidative stress, measuring lipid peroxide levels on each sample. Mann-Whitney test was done for statistical analysis of the data. Results : Nuclear staining of NF-κB (p50) was seen more intensively within the extravillous cytotrophoblast of preeclampsia group compared with the control group (p<0.05). The immunoreactivity of NF-κB (p50) was also detected in cytotrophoblasts, syncytiotrophoblasts, endothelium, and decidua, but showing no statistical difference between two groups. IκBα was strongly expressed in both groups but there was no statistically significant between two gropups. Preeclamptic group showed significantly increased circulating lipid peroxide levels compared to normal pregnancy group (1.22±0.79 nmol/mL vs 0.41±0.12 nmol/mL, p<0.05). Conclusion : The expression of NF-κB is significantly increased in extravillous cytotrophoblast of preeclamptic women compared to normal pregnancy, and may be associated with increased levels of circulating lipid peroxide. These findings might help us to understand the pathologic mechanism of preeclampsia and further study should be done for effects of NF-κB on implantation.