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症例(증례) : 자동차 페인트 도장공에서 발생한 과민성 폐장염 1례
오미나 ( Mi Na Oh ),조명진 ( Myoung Jin Cho ),백훈기 ( Hoon Ki Baek ),조기성 ( Ki Sung Cho ),강지훈 ( Ji Hoon Kang ),김영 ( Young Kim ),곽진영 ( Jin Young Kwak ) 전북대학교 의과학연구소 2008 全北醫大論文集 Vol.32 No.1
Isocyanate is widely used chemicals to make chemical products. It is known that is associated with hypersensitivity pneumonitis. Here we report a case of hypersensitivity pneumonitis in a automobile painting sprayer. A 42-year-old male patient visited the hospital with exertional dyspnea, cough, and sputum. He has worked as an automobile painting sprayer for last 6 months. His chest X-ray showed an interstitial pulmonary infiltration and High resolution computed tomography showed a diffuse ground glass appearance and tiny nodular infiltration in both lung field. Pulmonary function test showed a lung function of restrictive pattern : FEV1 2.5L(80%), FVC 2.83L(73%), FEV1/FVC 88%, TLC 3.70L(74%), and a decreased DLCO (10.5L/mmHg/min(50%)). Bronchoalveolar lavage showed an increased lymphocyte count (75%). And the pathologic finding of lung tissue by transbronchial biopsy showed interstitial inflammation with a nonnecrotizing granuloma. So we can assume that the diagnosis of this patient is the hypersensitivity pneumonitis caused by a automobile painting sprayer (Isocyanate)
오미나 ( Mi Na Oh ),조명진 ( Myoung Jin Cho ),백훈기 ( Hoon Ki Baek ),조기성 ( Ki Sung Cho ),강지훈 ( Ji Hoon Kang ),김영 ( Young Kim ),곽진영 ( Jin Young Kwak ) 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.6
Hypersensitivity pneumonitis (HP) is an immunologically-mediated disease resulting from repeated exposure to sensitizing agents, such as organic dusts or chemicals. Isocyanate is a volatile and highly reactive chemical that is extensively used in the manufacturing of automobiles, upholstery, and polyurethane foam. Occupational respiratory diseases associated with isocyanate, such as bronchial asthma, are well-known. It is thought that HP is one of the rare diseases induced by isocyanate with a very low frequency worldwide. We report a case of HP in an automobile painting sprayer which appeared to be associated with isocyanate. (Tuberc Respir Dis 2008;65:541-545)