http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
비후된 심근에서의 유세포 분석을 통한 Nuclear DNA 의 관찰
김성진(Sung Jin Kim),방인숙(In Sook Bang),박언휘(Eun Hwi Park),김홍주(Heung Joo Kim),김도헌(De Heon Kim),이예봉(Ye Bong Lee),윤성철(Sung Chul Yun),한동선(Dong Sun Han),김성숙(Sung Sook Kim) 대한내과학회 1993 대한내과학회지 Vol.45 No.2
Background: During the development of the cardiac hypertrophy, cytoplasmic contents of cardiac myocyte usually increase, but the changes in the nucleus of myocytes are not well understood. Therefore, we used flow cytometry to study the changes of nuclear DNA in cardiac hypertrophy from human autopsy heart tissue. Besides, we also tried to see the DNA ploidy of developing heart of fetus. Method: Nine hypertrophied human hearts ranging from 350-620 g (Group II: 350-500 g, Group III: > 500 g) and 9 control hearts (Group I: 250-350 g) which we could obtain after the legal autopsy were studied with flow cytometric analysis. And 3 fetal hearts of 20-24 gestational weeks (Group IV) were also studied. Nuclear DNA was analyzed with FACScan (Becton-Dickinson Co.) after tissue preparation using Modified Hedley and Vindelov Method and staining with Krishan staining buffer. Results: In control hearts (Group I), Flow cytometric analysis showed normal Diploidy pattern in all tissue. However, in cardiac hypertrophy, Non-Diploidy pattern was predominant (3 out of 5 specimen in Group II, and all 4 specimen in Group III) and Tetraploidy was usually observed in this abnormal ploidy pattern, but Aneuploidy was also seen in 2 cases of severe hypertrophy of Group III. Proliferative indexes increased progressively in Group I, II, and III (17.8±5.55, 24.8±7.4%, and 36.4±5.2%, respectively) (p<0.05 between Group I and II, and p<0.01 between Group I k III). Normal growing heart tissue of fetus showed normal Diploidy pattern. Conclusions: In cardiac hypertrophy, abnormal nuclear DNA ploidy pattern can be obseved. This finding might say that, during the genesis of cardiac hyper- trophy, not only cytoplasmic change but also DNA synthesis in the nucleus occurs, but G2 phase arrest happens without further mitosis.
실험적으로 일이킨 백서에서의 바이러스성 심근염에 대한 연구
박언휘(Eun Hwi Park),김흥주(Heung Joo Kim),김성진(Sung Jin Kim),방인숙(In Sook Bang),박성진(Seong Jin Park),구정완(Jung Wan Ku),윤성철(Sung Chul Yun),한동선(Dong Sun Han),정준호(Joon Ho Jung),김성숙(Sung Sook Kim) 대한내과학회 1993 대한내과학회지 Vol.45 No.1
Background: The authors injected EMC virus (Encephalomyocarditis virus) to induce viral myocarditis in ICR mice in order to study the survival rate and serial histopathologic change of viral myocarditis according to duration. Methods: Seventy adult male ICR mice of 8 to 10 weeks were used for experiment. Among 70 mice, 40 mice (Group I) were used to observe survival and 30 mice (Group II) were used to see serial histopathologic change (Each 5 mice were killed before and 5, 10, 20 days after virus injection). The hearts of animals were fixed in 10% buffered formalin and routinely processed. Hematoxylin & Eosin stain and Masson trichrome stain were done to observe inflammation and fibrosis. Results: 1) In Group I, 1 mouse died at each 2, 4, 5, 6 day after virus injection, and 4 mice died at 7 day and 2 mice died at 10 and 11 day. Total 10 animals among 40 died (mortality: 25%), and showed peak death period at 4-7 days, 2) In Group II, at 5th, 10th, 20th day after virus injection, average inflammatory grade in the myocardium were 1.8, 3.4, 2.0, respectively. 3) Histologic findings revealed monouclear cells infiltration, myofiber necrosis & degeneration. These changes occur multifocally rather than diffusely. Inflammation was most severe at 10 days. 4) Fibrosis was increased at 20 days after virus injection compared to early phase of myocarditis. Distribution of fibrosis is relatively parallel with the area of inflammation, but not with the degree of inflammation. 5) In some cases, dilation of both atriums and ventricles and thrombosis accompaning severe pulmonary congestion and edema were observed, indicating possible transition to dilated cardiomyopathy. Conclusions: It is considered that this experimental animal model may be useful not only to study the pathogenetic mechanisms of viral myocarditis but also to observe clinical course and evaluate the effect of possible drugs to treat myocarditis.
원발성 간암환자에서 관찰된 99mTc - DISIDA의 비장 섭취
윤성철(Sung Chul Yun),이예봉(Ye Bong Lee),김성진(Sung Jin Kim),박언휘(Eun Hwi Park),방인숙(In Sook Bang),김홍주(Heung Joo Kim),이원재(Won Jae Lee) 대한핵의학회 1993 핵의학 분자영상 Vol.27 No.1
We report a case of hepatorna which had a suggested splenic metastasis in a 64 year-old male patient. Hepatoma proved by abdominal CT (Cornputed Tomography) and considerable accumulation of 99mTc-DISIDA was noted in a enlarged sp]een. We suggests the splenic uptake of the radionuclide corresponded to the diffuse metasfasis of hepatorna to spleen.