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박용민 ( Yong Mean Park ),정소정 ( So Chung Chung ),유광하 ( Kwang Ha Yoo ) 대한천식알레르기학회 2012 천식 및 알레르기 Vol.32 No.2
Background: Bacterial and viral infections are closely related to development and exacerbation of asthma in children. The incidences of both asthma and the latent infection of tuberculosis are increasing in Korea. This study aimed to determine whether the prevalence of the latent infection of tuberculosis could be higher in asthmatic children compared to non-allergic children. Methods: We enrolled 30 asthmatic patients and 26 nonallergic patients who visited our hospital between 2008 and 2010. Total immunoglobulin E (IgE) levels, specific IgE levels and total eosinophil counts were measured. QuantiFERON-TB Gold (Cellestis Ltd., Carnegie, Victoria, Australia) was used to check for the status of the latent tuberculosis infection in both groups. Results: The positive response rate to QuantiFERON-TB Gold was significantly higher in the asthmatic patients than in the nonallergic children (67% vs. 38%, odds ratio=3.2; 95% confidence interval, 1.07∼9.57). Conclusion: The results of this study indicate the higher incidence of the latent infection of tuberculosis in pediatric asthmatic patients. (Korean J Asthma Allergy Clin Immunol 2012;32:101-106)
박용민 ( Yong Mean Park ) 대한소아알레르기호흡기학회 2006 소아알레르기 및 호흡기학회지 Vol.16 No.3
Atopic dermatitis is a common chronic inflammatory skin disease often preceding the development of asthma and allergic disorders, such as food allergy or allergic rhinoconjunctivitis. The incidence of atopic dermatitis is increasing, and this poses a major burden on health care costs. The pathophysiology of atopic dermatitis has long remained enigmatic, but much scientific effort has been invested in elucidating the genetic background and the immunological mechanisms underlying atopic dermatitis. Pathophysiology involves a complex series of interactions between resident and infiltrating cells orchestrated by proinflammatory cytokines and chemokines. A deficiency of antimicrobial peptides might contribute to the propensity for colonization or infection by microbial organisms seen in atopic dermatitis. New management approaches have evolved form advances in our understanding of the pathophysiology of this common skin disorder. [Pediatr Allergy Respir Dis(Korea) 2006;16:189-196]
박용민 ( Yong Mean Park ) 대한소아알레르기호흡기학회 2010 소아알레르기 및 호흡기학회지 Vol.20 No.4
Eosinophilia is common feature in many diseases, including allergic diseases. There are many factors involved in the survival and the death of eosinophil. Apoptosis is the most common form of physiological cell death and a necessary process to maintain cell numbers in multicellular organisms. It has been directly demonstrated that eosinophil apoptosis is delayed in allergic inflammatory sites, and that this mechanism contributes to the expansion of eosinophils in tissue. Overexpression of interleukin-5 appears to be crucial for delaying eosinophil apoptosis. Besides survival cytokines, eosinophil apoptosis is also regulated by death factor. Recent observations suggest a role for mitochondria in conducting eosinophil apoptosis, although the mechanisms that trigger mitochondria to release proapoptotic factors remain less clear. Acceleration of eosinophil apoptosis can be achieved by decreased expression of eosinophil survival factors, and promotion of death signals. However, many previous studies on the regulation of apoptosis have utilized cell lines which may not directly represent cells within the in vivo environment. Therefore, the control of eosinophil apoptosis can be another therapeutic strategy in allergic diseases. [Pediatr Allergy Respir Dis(Korea) 2010;20:219-225]
박용민 ( Yong Mean Park ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2011 소아알레르기 및 호흡기학회지 Vol.21 No.2
Atopic dermatitis (AD) is one of the most common chronic childhood skin diseases affecting up to 30% of children in the Korea. The point prevalence of AD has increased based on validated questionnaires in the most recent update of the International Study of Asthma and Allergies in Childhood. The evaluation of risk factors of AD is very important to develop the therapeutic strategies of AD. Many risk factors were studied to evaluate the relationship with the prevalence of AD. However, the results were quite different depending on methods of study, study population, and country. The further objective and well designed prospective epidemiologic studies are required to confirm these outcomes because the environmental and risk factors may be different among the countries according to their living cultures. [Pediatr Allergy Respir Dis(Korea) 2011;21:74-77]
한국 소아 알레르기비염 환자의 삶의 질에 대한 설문 개발 및 유용성 평가를 위한 연구
진장용 ( Jang Yong Jin ),양현종 ( Hyeon Jong Yang ),전유훈 ( You Hoon Jeon ),김경원 ( Kyung Won Kim ),김우경 ( Woo Kyung Kim ),박용민 ( Yong Mean Park ),윤혜선 ( Hae Sun Yoon ),염혜영 ( Hye Yung Yum ),편복양 ( Bok Yang Pyun ) 대한천식알레르기학회 2009 천식 및 알레르기 Vol.29 No.4
Background: A questionnaire for assessing the quality of life (QOL) of children with allergic rhinitis has not been developed in Korea. Objective: Our study was designed to develop and validate a Questionnaire for QOL Specific to Allergic Rhinitis in Korean Children (QQOL-ARK). Method: The QQOL-ARK consisted of 4 domains including 18 items with a 5-point scale: symptoms (3 items), physical factors (8 items), psychosocial factors (6 items) and prognosis (1 item). A survey with the QQOL-ARK was performed on 168 children with allergic rhinitis twice, 4 weeks apart. We analyzed their responsiveness, reproducibility and validity. Result: The mean score of QOL according to the severity showed a statistically significant difference between the first and second visits (P<0.01). The scores of QOL were decreased in the improved group (P<0.01) and increased in the worsen group (P<0.01). The differences in scores between the first and second visits showed a statistically significant difference in intergroup analysis (P<0.01). The QQOL-ARK also showed a good reproducibility (R=0.97). There was no strong correlation between QOL and clinical severity. Conclusion: The QQOL-ARK showed a good reproducibility and validity. However, the assessment of reliability on 18 items of the questionnaire could not be performed. Although the items of this questionnaire are limited, they could provide the basis for the development of the QOL questionnaire for Korean children with allergic rhinitis in conjunction with clinical evaluation. (Korean J Asthma Allergy Clin Immunol 2009;29:242-248)