http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 박시내(Shi Nae Park) (검색결과 22 건)
- 무료
- 기관 내 무료
- 유료
-
-
-
난청 동물모델에서 신경성장인자에 의한 청력회복과 나선 신경절재생에 관한 연구
오정훈 ( Jung Hoon Oh ),박시내 ( Shi Nae Park ),최혁기 ( Hyeog Gi Choi ),최미영 ( Mi Yung Choi ),한민아 ( Min Ah Han ),박경호 ( Kyoung Ho Park ),여상원 ( Sang W. Yeo ) 한국조직공학·재생의학회 2008 조직공학과 재생의학 Vol.5 No.4
Cochlear prostheses for the sensorineural hearing impairment are dependent on survival and excitability of the auditory nerve. Multiple neurotrophic factors have been shown to have important roles in the survival of auditory neurons and protecting spiral ganglion cells. This study evaluated the efficacy of brain-derived neurotrophic factor(BDNF) combined with glial-cell derived neurotrophic factor(GDNF) and neurotrophin-3(NT-3), insulin growth factor(IGF), and epidermal growth factor(EGF) with fibroblast growth factor(FGF) application in 2 weeks post-deafening guinea pigs. Healthy 30 guinea pigs were deafened by infusion of kanamycin and ethacrynic acid. Myringotomy was done in both ears, gelfoams immersed with neurotrophic factors were placed on the round window membrane while gelfoams immersed with saline were applied to control ear. On 1 week after drug application, hearing test was done and the cochleae were collected in every 2 weeks. And the number of spiral ganglion cells was quantitatively analyzed. Significant hearing restoration was observed in group 1(BDNF, GDNF, NT-3 treated group) & group 2(IGF treated group). The number of spiral ganglion cells of group 1 on 5 week after the treatment, and group 3(EGF, FGF treated group) on 3 week after the treatment were significantly increased them compared with control group. However, no statistically significant regeneration was observed in group 2. These findings demonstrate that BDNF+GDNF+NT-3 neurotrophic factor application through round window membrane have the potential for regeneration of spiral ganglion cells & hearing restoration.
-
-
-
강윤진(Yun Jin Kang),박정미(Jung Mee Park),한정주(Jung Ju Han),박시내(Shi Nae Park) 대한두개저학회 2017 대한두개저학회지 Vol.12 No.2
Calcinosis cutis is a rare disease consisted of insoluble calcium salts in the skin and subcutaneous tissue. This can be categorized into 5 groups according to pathogenesis: dystrophic, metastatic, idiopathic, iatrogenic calcinosis cutis and calciphylaxis. Have been categorized into idiopathic one which occurs without any other external damage or underlying systemic disease. Here, we report one case of histologically confirmed congenital calcinosis cutis appeared as a growing mass on the right auricle with its interesting preoperative finding on magnetic resonance imaging scan which has never been reported before.
-
진주종으로 오인된 측두골에 발생한 섬유성 이형성증 1례
김인혜(In Hye Kim),박정미(Jung Mee Park),한정주(Jung Ju Han),박시내(Shi Nae Park) 대한두개저학회 2018 대한두개저학회지 Vol.13 No.2
Fibrous dysplasia is a bone disorder of unknown origin in which normal bone is replaced with fibrotic tissue and disorganized bone trabeculae. The temporal bone is known to be rarely affected. Because of the slowly progressive course of the disease, many cases are diagnosed incidentally through an imaging study without any symptom. Here, we report one rare case of histologically confirmed fibrous dysplasia of the temporal bone which was initially misdiagnosed as a cholesteatoma of middle ear. Surgical outcomes of hearing and symptomatic relief were satisfactory in this 25-year-old symptomatic female patient.
-
이수현(Su Hyun Lee),나미선(Mi-Sun Na),여상원(Sang Won Yeo),박시내(Shi Nae Park) 대한두개저학회 2015 대한두개저학회지 Vol.10 No.1
Iatrogenic temporal bone meningoencephalocele (MEC) through the defect site of tegmen can be occurred after the surgical procedure of mastoidectomy even though its clinical manifestations and prognosis are not well known till now. Six years ago, the patient underwent canal wall up mastoidectomy due to chronic otitis media and had a 5mm in diameter iatrogenic loss of dural plate without any direct dural injury during the surgery. Recurrence of chronic otitis media led him to take reoperation. He did not show any cranial nerve symptoms or signs but preoperative temporal bone computed tomogram demonstrated suspicious MEC in the mastoid cavity. Here, we report a case of asymptomatic but clinically important iatrogenic MEC.
-
유동준(Dong Joon Yoo),이성훈(Sung-Hun Lee),여상원(Sang Won Yeo),박시내(Shi-Nae Park) 대한두개저학회 2014 대한두개저학회지 Vol.9 No.1
Xanthogranuloma is one of non-Langerhans cell histocytic disorders. And adult-onset huge xanthogranuloma of the external auditory canal is very rarely reported, especially on this anatomical site. We introduce a case of adult-onset huge xanthogranuloma of the external auditory canal. An 32-year-old female presented with intermittent left bloody otorrhea for two months. Radiological studies showed a solitary mass on the posterior wall of external auditory canal that had no invasion or erosion of temporal bone. The mass that originated from the posterior wall of the external auditory canal was excised and the defect site was reconstructed with ipsilateral superficial temporalis fascia. Pathologically, this huge mass was diagnosed as xanthogranuloma. We report this case as a very rare case of adult-onset xanthogranuloma in the external auditory canal as well as its excellent long-term result of surgery with the review of the literatures.
-
최혁기 ( Hyeog Gi Choi ),김창현 ( Chang Hyun Kim ),박시내 ( Shi Nae Park ),최미영 ( Mi Yung Choi ),남승규 ( Seung Gyu Nam ),박성천 ( Sung Chun Park ),이성재 ( Sung Jae Lee ),이종민 ( Chong Min Lee ),이세윤 ( Sei Yun Lee ),여상원 ( 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
The somatic stem cells in the auditory organs can be utilized for the treatment of sensory neuronal hearing loss. The aim of this study was to isolate and culture of adult stem cells from guinea pig spiral ganglion in order to investigate the presence of soamtic stem cells in auditory organs of adult mammals. Spiral ganglions were obtained from the cochlea of guinea pigs, which weigh about 300 g. The tissues were dissociated and cultured in a medium added with epidermal growth factor and fibroblast growth factor. Then they were labeled with many markers for the stem cells and their differentiated cells, and identified under immunofluorecence microscope to find out the presence of somatic stem cells. The cultured cells can differentiate into neuronal cells positive for β III tubulin and glial cells positive for S-100. They were confirmed to be differentiated cells from neurosphere as the positive results for known stem cell marker such as bromodeoxyuridine(BrdU) and nestin. It was confirmed that the neural stem cells were existed in the spiral ganglion of guinea pig, which have the capability of self renewal and differentiation into specific neural cells. This fact presents a possibility of stem cell treatment for the patients of hearing impairment.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
