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        당뇨병과 폐결핵 합병례에 대한 고찰

        하태정(Tae Jung Ha),이선희(Sun Hee Lee),정영태(Young Tae Jung),박병규(Peong Kew Park),김용기(Yong Ki Kim),박순규(Soon Kew Park),신영기(Yeong Kee Shin) 대한내과학회 1996 대한내과학회지 Vol.50 No.3

        Objectives: Diabetes mellitus was known to cause a variety of complications, and was highly sensitive to the infections. Based on this fact, the studies which suggested the relationship between diabetes and pulmonary tuberculosis have been reported for a long time. With some exceptions, the prevalence of pulmonary tuberculosis was significantly higher in diabetic patients compared with non-diabetics and, especially, occurrence of tuberculosis in the lower lung field was strongly emphasized in diabetic patients. Author analyzed the clinical characteristics of patients with pulmonary tuberculosis complicated with diabetes mellitus and control group who were pulmonary tuberculosis without diabetes. Methods: The medical records of 582 patients who admitted with diabetes mellitus at Pusan National University Hospital from January 1, 1993 to July 30, 1994 were reviewed. Among them, 50 patients with pulmonary tuberculosis complicated with diabetes were investigated. As a control groups, 50 nondiabetic patients with pulmonary tuberculosis who were admitted to this hospital during the same period and were matched according to age and sex were evaluated. In addition, to examine the relationship between patients with pulmonary tuberculosis complicated with diabetes and control group, author partly used the Report on the Sixth tuberculosis Prevalence Survey as a another control group. Lower lung field tuberculosis was defined as tuberculosis involving the right middle lobe, left lingula segments, and one or both lower lobes without upper lobe lesions. Results: 1) Among 582 diabetic patients, 50 cases(8.6%) had pulmonary tuberculosis on chest X-ray and 40 cases(6.9%) were positive acid fast bacilli on sputum smear, it was much higher incidence compared with control group, 2.3% and 0.35% respectively. 2) Thirty six(12.5%) of 287 male and 14(4.7%) of 295 female diabetic patients had pulmonary tuberculosis, the overall sex ratio was 2.7 versus l. 3) According to the radiological classification of pulmonary tuberculosis in 50 diabetic patients, minimal tuberculosis cases were 16(32%), moderate advanced cases were 20(40%), and far advanced cases were 14(28%). The ratio of the moderate advanced and the far advanced pulmonary tuberculosis in diabetics was higher than the control group. 4) Ten of 50 patients with diabetes were noted to have only lower lung field involvement in both lung fields, however no lower lung field disease was observed in nondiabetic group. Among 10 diabetic patients with lower lung field tuberculosis, 9 cases(90%) were bacteriologically confirmed, of the 50 patients with pulmonary tuberculosis complicated with diabetes occurred in the right upper lobe with 33(66%), in the right middle lobe with 9(18%) and in the right lower lobe with 16(32%). On the other hand in the left lung, the frequency was 25(50%) in the left upper lobe, 9(18%) in the lingula segments and 13(26% in the left lower lobe. 5) The incidence of hemoptysis was higher in the patients with pulmonary, tuberculosis complicated diabetes(28%, 14 of 50) than in the control group(12%, 6 of 50)(p<0.05). Conclusion: By the above results, it could be concluded that the diabetic patients had much more incidence of prevalence, hemoptysis and moderated and far advanced pulmonary tuberculosis compared with controul group, and had a high possibillity of pulmonary tuberculosis in the lower lung field.

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