지역사회 건강관련 삶의 질에 영향을 미치는 요인

정용래(Yong-Rae Jeong),함명일(Myung-Il Hahm),민인순(In-Soon Min),강은정(Eunjeong Kang) 한국콘텐츠학회 2015 한국콘텐츠학회논문지 Vol.15 No.1

이 연구의 목적은 우리나라의 지역사회 건강관련 삶의 질에 영향을 미치는 지역사회 요인을 확인하기 위함이다. 2012년 단면연구이며, 국가통계포털의 209개의 시군구별 2차 자료를 사용하였다. 기본 틀은 International Council of Science(ICSU)에서 제시한 지역사회 건강결정요인을 바탕으로 구성하였고, 6가지 측면으로 분류하였다. 분석방법은 지역사회 EQ-5D지수와 지역사회 요인들에 다변량 회귀분석을 실시하였다. 분석결과로, 흡연율, “양호한” 주관적 건강수준 인식률, 상수 및 하수도 보급률 그리고 재정자립도가 EQ-5D에 통계적으로 유의하게 긍정적인 연관성이 있었다. 순인구이동률, 비만율, 필요서비스 미치료율 그리고 지역사회 유형이 EQ-5D에 통계적으로 유의하게 부정적인 연관성이 있었다. 이 연구는 지역사회 수준의 건강관련 삶의 질에 영향을 미치는 지역사회 요인들의 연관성을 확인했으며, 이것은 지역사회 건강 정책 개발에 유용한 증거를 제공할 수 있다. The aim of this study was to identify the impact of community factors on the community-level Health-Related Quality of Life (HRQOL) in Korea. This was a cross-sectional study conducted in 2012 using secondary data(n=209) of the Korean Statistical Information Service. The framework was based on community factors provided by the International Council of Science (ICSU) and community factors were categorized based on six aspects. Multiple regression was applied to community factors depending on the community EQ-5D index. Smoking rate, “Good” self-rated health rate, water and wastewater coverage rate, and financial independency rate were significantly and positively associated with the EQ-5D score. Net migration rate(more move out than move in), obesity rate, unmet needed health care rate, and community type(rural than urban) were significantly and negatively associated with the EQ-5D score. This study identifies association for the impact of community factors on the community-level HRQOL and can provide useful evidence for development of community health promotion policies.

암가족력 유무에 따른 부정적 심리요인과 유방암 검진과의 관련성: 우리나라 여성을 중심으로

김복미 ( Bokmi Kim ),최귀선 ( Kui Son Choi ),이윤노 ( Yoon Noh Lee ),민인순 ( In Soon Min ),함명일 ( Myung-il Hahm ) 한국보건행정학회 2017 보건행정학회지 Vol.27 No.2

Background: Women with family history of breast cancer are more likely to be worried about having cancer and participate in breast cancer screening. However, few studies have examined relationship between family history, cancer worries, and participating in breast cancer screening in Korea. This study is to identify relationship between family history, cancer worries, and participating in breast cancer screening among women with and without family history of cancer. Methods: Respondents were 2,364 women who based on the 2013 Korean National Cancer Screening Survey which is done by National Cancer Center in Korea. Chi.square tests were performed to determine differences of cancer worries, undergoing of breast cancer screening and methods such as mammogram and ultrasonogram with and without cancer family history. Univariate and multiple logistic regression were performed to identify if family history and cancer worries are related factors on participating in breast cancer screening and methods. Stratified analysis was performed to confirm the effect of ultrasonogram on the dense breast by age. Results: Women with cancer family history frequently checked condition for conscious of having cancer (p=0.0299) and had highly perception of risk about having cancer in the future (p≤0.0001). Women aged 30-49 did not perform significantly more ultrasonogram than women aged over 50 years old. Checking condition (moderate odds ratio [OR], 1.38; 95% confidence interval [CI], 1.20-2.08; frequently OR, 1.58; 95% CI, 1.08-1.76) and perception of risk (moderate OR, 3.12; 95% CI, 1.06-7.06; high OR, 2.74; 95% CI, 1.20-8.08) were related to participate in mammogram and ultrasonogram. A positive family history was related to 1.35 higher odds of performing only breast ultrasonogram (95% CI, 1.04-1.75). Conclusion: This study requires national education and publicity to reduce the unnecessary cost of screening, to be possible cost effective screening and to encourage women to receive more mammogram, especially women aged over 50 years old and with socioeconomic factors related to opportunistic screening.

청소년 위험행동과 흡연과의 상관성

이준범 ( Jun Beom Lee ),함명일 ( Myung-il Hahm ),김동준 ( Dong Jun Kim ),조하현 ( Ha-hyeon Cho ),민인순 ( In Soon Min ) 한국병원경영학회 2019 병원경영학회지 Vol.24 No.2

Purposes: The purpose of this study was to examine the association between risk behaviors and smoking in Korean adolescents. Methods: This study used data from online survey of youth health behavior in 2017. Data from a total of 54,411 people (27,139 male, 27,272 female) were included in the analysis. chi-square test, simple logistic regression, multiple logistic regression were performed using SAS 9.4. Findings: Multiple logistic regression analysis showed that risk behaviors such as drinking alcohol experience, sexual experience, drug use experience and high caffeine energy drinks intake experience had a significant effect on smoking. Adolescents with drinking experience were more likely to smoking than those who had no experience(OR=8.58, 95% CI: 7.67~9.60). Adolescents with sexual experience were more likely to smoking than those who had no experience(OR=4.47, 95% CI: 3.91~5.11). Adolescents with drug use experience were more likely to smoking than those who had no experience(OR=2.32, 95% CI: 1.63~3.32). Also, adolescents with high-caffeine energy drinks intake experience were more likely to smoking than those who had no experience(OR=1.37, 95% CI: 1.23~1.53). Practical Implications: All the risk behaviors were significantly associated with smoking rates. Results of this study suggest that physicians and health workers in medical institutions and health centers should simultaneously serve education and consultation for the smoking cessation as well as for the prevention of risk behaviors.

Curcumin은 ovalbumin에 의해서 유도된 inducible nitric oxide synthase 억제

김지수(Ji Soo Kim),안희진(Hee Jin Ahn),신화정(Hwa-Jeong Shin),구교정(Gyo-Jeong Gu),엄상훈(Sang Hoon Eum),이청호(Chung Ho Lee),민인순(In Soon Min),윤형선(Hyung-Sun Youn) 한국식품과학회 2012 한국식품과학회지 Vol.44 No.4

본 연구에서 curcumin이 계란 알러젠 중의 하나인 OVA에 의해서 유도된 NF-κB 활성화 및 iNOS 발현에 어떤 영향을 미치는지 알아보았다. Curcumin은 OVA에 의해서 유도된 NF-κB 활성화와 iNOS 발현을 억제시켰다. 이러한 결과는 curcumin이 계란 알러젠인 OVA에 의해서 유도된 NF-κB의 활성화와 iNOS의 발현을 억제하여 염증반응이나 알러지와 같은 만성적인 질병들을 조절할 수 있다는 것을 보여주는 중요한 결과라 사료된다. 이러한 연구는 추후 알러지 작용기전 규명 및 알러지 치료제 개발에 중요한 역할을 할 것으로 기대한다. Egg allergy has been reported as the most prevalent food hypersensitivity among children. One of the major egg allergens is ovalbumin (OVA). OVA is the major protein in the egg white, comprising 54% of its total protein content. Curcumin isolated from Curcuma longa has been used as folk remedies in order to treat many chronic diseases for many years. In the present report, we present biochemical evidence that curcumin inhibits the NF-κB activation induced by OVA. Curcumin also inhibits OVA-induced iNOS expression and nitrite production. These data suggest new approaches for the development of efficient anti-allergic strategies.

Ovalbumin에 의한 cyclooxygenase-2와 inducible nitric oxide synthase 유도

이아늠(A-Neum Lee),박세정(Se-Jeong Park),정애리(Ae-Ri Jeong),이재란(Jae-Ran Lee),박혜정(Hye-Jeong Park),김수정(Soo-Jung Kim),민인순(In Soon Min),윤형선(Hyung-Sun Youn) 한국식품과학회 2011 한국식품과학회지 Vol.43 No.1

음식 알러지는 만성적인 장애를 일으킬 수 있는 즉각적이며 잠재적으로 생명을 위협하는 반응이다. 이 중 계란은 알러지 위험성이 높은 물질로, 아이들에게 음식 알러지를 유발하는 흔한 물질로 알려져 있다. 계란 알러젠 중에서 계란 흰자 단백질인 OVA 이 주요한 알러젠으로 알려져 있다. 우리는 이번 연구에서 OVA 이 염증 및 면역 반응에 중요한 역할을 한다고 알려져 있는 NF-κB 활성화와 COX-2와 iNOS 발현에 어떠한 영향을 미치는지를 알아보았다. OVA은 NF-κB 활성화와 COX-2와 iNOS의 발현을 증가시켰다. 이러한 연구는 앞으로 계란 알러젠에 의한 알러지 작용기전 규명 및 알러지 치료제 개발에 중요한 역할을 할 것으로 기대한다. Egg allergies are the most prevalent food hypersensitivity in children. The major egg allergens are proteins, such as ovalbumin (OVA) and ovomucoid (OVM), which are mainly contained in egg whites. OVA is the major protein in egg white, comprising 54% of the total protein content. OVA has been widely used in experimental inhalant and dietary allergy animal models, but its mechanism has not been clearly identified. In this study, we showed that OVA induced nuclear factor-κB activation. OVA also induced the expression of cyclooxygenase-2 and inducible nitric oxide synthase. These data suggest new approaches for developing efficient anti-allergic strategies.

Phenethyl Isothiocyanate가 Toll-Like Receptor Agonists에 의해 유도된 Nuclear Factor-κB 활성과 Cyclooxygenase-2, Inducible Nitric Oxide Synthase 발현에 미치는 효과

김수정 ( Soo Jung Kim ),박혜정 ( Hye Jeong Park ),신화정 ( Hwa Jeong Shin ),김지수 ( Ji Soo Kim ),안희진 ( Hee Jin Ahn ),민인순 ( In Soon Min ),윤형선 ( Hyung Sun Youn ) 한국응용생명화학회(구 한국농화학회) 2011 Journal of Applied Biological Chemistry (J. Appl. Vol.54 No.4

염증의 중요한 분자학적 기전에는 cyclooxygenase-2 (COX-2)에 의한 prostaglandins (PGs) 생성과 inducible nitric oxide synthase (iNOS)에 의한 nitric oxide (NO) 생성이 있다. 많은 종류의 박테리아나 바이러스가 전사요소인 nuclear factor-κB(NF-κB)를 활성화시켜 여러 타깃 유전자의 발현을 조절해 PGs나 NO와 같은 염증물질을 유도하게 된다. 우리는 이번 실험을 통하여 phenethyl isothiocyanate (PEITC)가 toll-like receptor (TLR) agonists에 의해 유도된 NF-κB활성과 COX-2, iNOS 발현에 어떠한 영향을 미치는지 알아 보았다. PEITC는 lipopolysaccharide (LPS)와 polyinosinic-polycytidylic acid (poly[I:C])에 의해 유도된 NF-κB활성을 억제시켰다. 또한 PEITC는 LPS와 Poly[I:C]에 의해 유도된 iNOS의 발현도 억제시켰다. 하지만 PEITC는 TLR agonists들인 LPS, Poly[I:C], 2kDa macrophage-activating lipopeptide (MALP-2), oligodeoxynucleotide 1668 (ODN1668)에 의한 COX-2 발현은 억제시키지 못하였다. 즉 PEITC가 TRIF-dependent 신호전달체계만을 조절하여 TRIF-dependent 신호전달체계에 의해 조절되는 iNOS는 억제하지만 MyD88-dependent 신호전달 체계에 의해 조절되는 COX-2는 억제하지 못한다는 것을 설명해준다. 이러한 결과는 iNOS와 COX-2가 서로 다른 메커니즘에 의해 조절된다는 것을 암시하며, PEITC가 여러 병원균들로부터 유도되는 염증반응이나 만성적인 질병들을 조절할 수 있음을 제시하는 중요한 결과이다. Toll-like receptors (TLRs) play an important role in induction of innate immune responses. The activation of TLRs triggers inflammatory responses that are essential for host defense against invading pathogens. Phenethyl isothiocyanate (PEITC) extracted from cruciferous vegetables has an effect on anti-inflammatory therapy. Dysregulated activation of nuclear factor-κB (NF-κB), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) has been shown to play important roles in the development of certain inflammatory disease. To evaluate the therapeutic potential of PEITC, NF-κB activation and COX-2 and iNOS expression induced by lipopolysaccharide (LPS, TLR4 agonist), polyinosinic-polycytidylic acid (Poly[I:C], TLR3 agonist), 2 kDa macrophageactivating lipopeptide (MALP-2, TLR2 and TLR6 agonist) or oligodeoxynucleotide 1668 (ODN1668, TLR9 agonist) were examined. PEITC inhibits the activation of NF-κB induced by LPS or Poly[I:C] but not by MALP-2 or ODN1668. PEITC also suppressed the iNOS expression induced by LPS or Poly[I:C]. However, PEITC did not suppress COX-2 expression induced by LPS, Poly[I:C], MALP-2, or ODN1668. These results suggest that PEITC has the specific mechanism for antiinflammatory responses.