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Substance P Modulates Properties of Bone Marrow-Derived Mesenchymal Stem Cells
마리아 호세 듀봉,변예지,Nunggum Jung,손영숙,박기숙 한국조직공학과 재생의학회 2014 조직공학과 재생의학 Vol.11 No.3
Bone marrow derived mesenchymal stem cells (MSCs) have self-renewal characteristics and are able todifferentiate into various cell types. These cells can mobilize to peripheral tissues in order to participate in importantbiological processes such as wound healing. They are also able to regulate hematopoietic stem cells (HSCs) traffick-ing between the bone marrow and the periphery through the regulation of intercellular interactions and the expres-sion of cytokines, such as SDF-1. Previous studies demonstrated that substance P (SP) induces the proliferation ofMSCs in vitroand mediates the migration of MSCs to injury sites to promote healing. We found that SP increasesCFU-F of the bone marrow total cells and up-regulates the osteogenic differentiation potential of MSCs withoutaffecting their adipogenic differentiation potential. We also found that SP increases the mRNA levels of SDF-1 andN-cadherin in total bone marrow. Therefore, it is very likely that SP modulates the properties of MSCs linked to theirtherapeutic potential and their role in trafficking of stem cells.
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Substance P and Thiorphan Synergically Enhance Angiogenesis in Wound Healing
엄지현,유진영,마리아 호세 듀봉,박기숙 한국조직공학과 재생의학회 2016 조직공학과 재생의학 Vol.13 No.2
Impaired angiogenesis is a common pathological characteristic of chronic wounds. Therefore, the regulation of angiogenesis is important for proper tissue repair. It was reported that substance P (SP) accelerates wound healing in a skin injury model. SP is degraded by neutral endopeptidase (NEP). Our study shows that systemic co-treatment of SP and thiorphan, an inhibitor of NEP synergically increased the number of α-smooth muscle actin positive-blood vessels in skin wounds. However, there was no synergic improvement in wound contraction and extracellular matrix deposition. Therefore, inhibition of endogenous NEP activity by thiorphan treatment might modulate the effects of SP treatment specifically on accelerating angiogenesis during wound healing. However, the molecular mechanism(s) of the synergic increase in angiogenesis by SP and thiorphan treatment is still unknown.
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Substance P Modulates Properties of Normal and Diabetic Dermal Fibroblasts
Nunggum Jung,유진영,엄지현,마리아 호세 듀봉,박기숙 한국조직공학과 재생의학회 2016 조직공학과 재생의학 Vol.13 No.2
Dermal fibroblasts play essential roles in wound healing. However, they lose their normal regenerative functions under certain pathologic conditions such as in chronic diabetic wounds. Here, we show that substance P (SP) rescues the malfunctions of dermal fibroblasts in diabetes. SP increased the proliferation of diabetic dermal fibroblasts dose-dependently, although the effect was lower compared to the SP-stimulated proliferation of normal dermal fibroblasts. In contrast to normal dermal fibroblasts, SP increased the expression level of vascular endothelial growth factor (VEGF) and stromal cell-derived factor-1 (SDF-1) in diabetic dermal fibroblast hence, rescuing their angiogenic potential. The cellular characteristics of diabetic dermal fibroblasts modulated by SP would be able to accelerate the wound healing process through faster wound contraction and improved angiogenesis in diabetic chronic wounds. Moreover, SP pretreatment into dermal fibroblasts isolated from diabetic patients would be a promising strategy to develop autologous cell therapy for treating diabetic chronic wounds.
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