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가미팔물탕(加味八物湯)이 생쥐의 비만억제에 미치는 영향
김효영 ( Hyo Young Kim ),허동석 ( Dong Seok Heo ) 한방재활의학과학회 2008 한방재활의학과학회지 Vol.18 No.2
Objectives : This study was performed to investigate inhibitory effects of Gamipalmul-tang(jiaweibawu-tang) on the hematological and histological changes of obese mice. Methods : C57BL/6 mice were divided into four groups (normal group, high fat diet with normal saline, high fat diet with reductil, high fat diet with Gamipalmul-tang(jiaweibawu-tang)) and fed for 8 weeks. Body weight change, final increase of body weight, ALT, AST, creatinine, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, glucose, cell viability by cytotoxicity, the expression of β3AR in 3T3-L1 cell, the expression of leptin, β3AR and serotonin in adipocyte tissue and size of adipocyte were observed in 8 weeks. Results : 1. In 3T3-L1 cell. the expression of β3AR was increased significantly. 2. The final increase of body weight in obese-mouse were decreased significantly. 3. The level of AST, ALT were decreased significantly. 4. The level of LDL-cholesterol was decreased significantly and HDL-cholesterol was increased significantly. 5. The levels of triglyceride was decreased and leptin and glucose were decreased significantly. 6. In adipocyte tissue, the expression of β3AR were increased significantly. 7 In adipocyte tissue, the expression of leptin and serotonin were decreased significantly. 8. The size of Adipocyte was decreased. Conclusions : On the basis of these results, we concluded that Gamipalmul-tang(jiaweibawu-tang) has inhibitory effects in rat.
장세정제 복용 후 발생한 횡문근융해증, 발작과 비심인성 폐부종의 합병증을 동반한 저나트륨혈증
손명수 ( Myung Su Son ),김효영 ( Heo Young Kim ),김용훈 ( Yong Hun Kim ),김원희 ( Won Hee Kim ),이소영 ( So Young Lee ),홍기연 ( Gi Youn Hong ),정훈 ( Hoon Jeong ),이용구 ( Yong Gu Lee ),양동호 ( Dong Ho Yang ),김형종 ( Hyung Jon 대한신장학회 2008 Kidney Research and Clinical Practice Vol.27 No.2
Oral sodium phosphate is commonly used to evacuate the colon and rectum before colonoscopy or colorectal surgery. However, this substance is known to cause electrolyte abnormalities including hyponatremia. The hyponatremic patient usually presents with headache, nausea, vomiting and confusion, but can also present with non-cardiogenic pulmonary edema, seizure and rhabdomyolysis. However, non-cardiogenic pulmonary edema, seizure and rhabdomyolysis caused by hyponatremia associated with bowel preparation have only rarely been reported. We report a case of severe complications including non-cardiogenic pulmonary edema, seizure and rhabdomyolysis associated with hyponatremia following ingestion of sodium phosphate for colonoscopy in a 41-year-old healthy male.
신장 : 급성 신부전을 동반한 부동화에 의한 고칼슘혈증성 신증 1예
오현주 ( Hyun Ju Oh ),박지수 ( Ji Soo Park ),김조은 ( Jo Eun Kim ),윤해리 ( Ha Rry Yoon ),김지수 ( Ji Soo Kim ),김효영 ( Heo Young Kim ),김형종 ( Hyung Jong Kim ) 대한내과학회 2012 대한내과학회지 Vol.82 No.6
본 증례는 부동화가 지속되는 상태의 환자에서 발생한 고칼슘혈증과 관련되어 급성신부전이 발생한 경우로, 드물기는 하지만 고칼슘혈증과 관련되어 급성 신부전이 발생할 수 있으며 글루코코르티코이드의 사용이 고칼슘혈증 및 급성신부전 호전에 도움이 될 수 있을 것이라 생각된다. Hypercalcemia commonly occurs because of primary hyperparathyroidism and metastatic malignancies, such as multiple myeloma, breast cancer and lung cancer; these causes account for 90% of cases. The other causes of hypercalcemia are numerous, and immobilization is an under-appreciated etiology. The mechanisms underlying immobilization-induced hypercalcemia are uncertain. However, an overall increased osteoclastic bone resorption and decreased osteoblastic bone formation can induce hypercalciuria and hypercalcemia. Additionally, hypercalcemia can induce and be associated with acute kidney injury, but it is rarely reported in immobilization hypercalcemia. We report here a 58-year-old man with suspected immobilization hypercalcemia associated with acute kidney injury and treated successfully with glucocorticoids.