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RISS 인기검색어
- 검색키워드
- 저자 : 김형석 ( Heyong Seok Kim ) (검색결과 3 건)
- 무료
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김명훈 ( Myeong-hun Kim ),문양선 ( Yang-seon Moon ),강상미 ( Sang-mi Kang ),김형석 ( Heyong-seok Kim ),김선종 ( Seon-jong Kim ),나창수 ( Chang-su Na ) 한방재활의학과학회 2022 한방재활의학과학회지 Vol.32 No.2
Objectives This study was conducted to investigate the beta-glucan & ginsenoside content, antioxidant activity, anti-inflammatory effect and safety of herbal medicine mix. Methods The marker compounds contents, antioxidant activity and safety of herbal medicine mix were tested. The contents of beta-glucan and ginsenoside Rg3 were measured, the antioxidant activity was measured using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity, anti-inflammatory and a safety test was conducted via single dose toxicity assessment. Results Analyzing the contents of marker compounds showed 362.3 mg/g of beta- glucan, and 0.4184 mg/g of ginsenoside Rg3. In the DPPH free radical scavenging activity, the IC50 of herbal medicine mix, was 0.146%. The scavenging activity of herbal medicine mix was 88.28% activity at 0.5% concentration, and 90.61% activity at 5% concentration. In the lipopolysaccharides (LPS) anti-inflammatory test, the herbal remix showed a significant decrease in tumor necrosis factor-alpha (TNF-α) and interleukin- 6 (IL-6) compared to the LPS-induced group. In the single dose toxicity test of herbal medicine mix, a dose of 2,000 mg/kg body weight (BW) was set at its highest capacity and observed after oral administration to female and male rats. No toxicological findings were recognized. It was observed that the resulting lethal dose can be set to 2,000 mg/kg BW or higher for both females and males. Conclusions The results of the experiment on herbal medicine mix showed that the marker compounds contents were beta-glucan and ginsenoside Rg3, that antioxidant activity was observed through the DPPH free radical scavenging activity, anti-inflammatory effect was observed through TNF-α and IL-6 measurement, and safety was confirmed through the single dose toxicity assessment. (J Korean Med Rehabil 2022;32(2):1-17)
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경옥고가미방의 베타글루칸, 진세노사이드 함량, 2,2-diphenyl-1-picrylhydrazyl (DPPH) Free Radical 소거 활성 및 단회 투여 독성 연구
이유미 ( Yu-mi Lee ),문양선 ( Yang-seon Moon ),박희명 ( Hee-myeong Park ),김형석 ( Heyong-seok Kim ),노웅빈 ( Woong-bin Ro ),나창수 ( Chang-su Na ) 한방재활의학과학회 2021 한방재활의학과학회지 Vol.31 No.1
Objectives This study was conducted to investigate the beta-glucan, ginsenoside content, antioxidant activity and safety of modified Kyungohkgo added to Sparassis crispa and Hericium erinaceum. Methods The marker compounds contents, antioxidant activity and safety of modified Kyungohkgo were tested. The contents of beta-glucan and ginsenoside Rb1, Rg1, and Rg3 marker compounds were measured, the antioxidant activity was measured using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity, and a safety test was conducted via single dose toxicity assessment. Results Analyzing the contents of marker compounds showed 351.75 mg/g of beta- glucan, 0.0327 mg/g of ginsenoside Rb1 and 0.0802 mg/g of ginsenosai Rg3. In the DPPH free radical scavenging activity, the inhibition concentration 50% of modified Kyungohkgo was 0.2880%. The scavenging activity of modified Kyungohkgo was 5.49% activity at 0.05% concentration, 89.66% activity at 0.5% concentration, 94.68% activity at 1% concentration, and 96.06% activity at 5% concentration. In the single dose toxicity test of modified Kyungohkgo, a dose of 2,000 mg/kg B.W. was set at its highest capacity and observed after oral administration to female and male rats. No toxicological findings were recognized. It was observed that the resulting lethal dose can be set to 2,000 mg/kg B.W. or higher for both females and males. Conclusions The results of the experiment on modified Kyungohkgo showed that the marker compounds contents were beta-glucan and ginsenoside Rb1 and Rg3, that antioxidant activity was observed through the DPPH free radical scavenging activity, and safety was confirmed through the single dose toxicity assessment. (J Korean Med Rehabil 2021;31(1):95-108)
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랫드에서 PMMA와 Cross-Linked Dextran 혼합물의 생체 안전성 및 부피 효과에 대한 연구
장민우 ( Min Woo Jang ),진부갑 ( Bu Kab Jin ),이상훈 ( Sang Hun Lee ),박재홍 ( Jae Hong Park ),류정민 ( Jung Min Ryu ),윤승필 ( Seung Pil Yun ),박성원 ( Sung Won Park ),김형석 ( Heyong Seok Kim ),문창종 ( Chang Jong Moon ),서국현 한국조직공학·재생의학회 2010 조직공학과 재생의학 Vol.7 No.1
This study examined bio-safety and volume-related effect of the mixture of polymethylmethacrylate (PMMA) and Cross-linked Dextran as a soft tissue augmentation. To examine bio-safety and volume-related effect of the mixture of PMMA and Cross-linked Dextran in rat, gross, hematological, and pathohistological examinations were performed in comparison with CRM (R) DX (Cross-linked hyaluronic acid sodium salt, Dextranomere; commercial product) and saline. During the experimental period, there was no dead rats and scratching behavior which is a most common symptom when rejecting foreign body was observed. The volume of injected mixture was maintained sufficiently. Complete blood count(CBC) finding indicated that there were no significant differences in the number of inflammatory cells between control and experimental group. In addition, the parameters of hepatic toxicity (aspartate aminotransferase: AST, alanine transaminase: ALT, alkaline phosphatase: ALP, γ-glutamyl transpeptidase: γ- GTP, lactate dehydrogenase: LDH), renal toxicity (creatinine, blood urea nitrogen: BUN, cholesterol, albumin: ALB, phosphorus), and other organ toxicity (calcium, triglyceride, and creatine phosphokinase: CPK) using serum biochemical analysis did not show the significant differences between the control and experimental group, suggesting that systemic toxicity was not found in liver, kidney, and other organs. Histopathological findings indicated that the subcutaneous tissue had red color microsphere which capsulated by collagen near the injection site. Furthermore, the infiltration of inflammatory cells were not observed in the injected sites of all experimental groups. In conclusion, the mixture of PMMA and Cross-linked Dextran can be a safe substance for soft tissue augmentation maintaining tissue volume.
ScienceON
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