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- 저자 : 김현영(Hyeon-Yeung Kim) (검색결과 1 건)
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김종춘(Jong-Choon Kim),신진영(Jin-Young Shin),신동호(Dong-Ho Shin),김성호(Sung-Ho Kim),이성배(Sung-Bae Lee),한정희(Jung-Hee Han),정용현(Yong-Hyun Chung),김현영(Hyeon-Yeung Kim),박승춘(Seung-Chun Park) 한국독성학회 2004 Toxicological Research Vol.20 No.3
The present study was carried out to investigate the potential toxicity of dimethyl disulfide<br/> by a 2-week inhalation in F344 rats. The test article, dimethyl disulfide, was exposed by inhalation<br/> to male and female rats at dose levels of 0, 33, 100, or 300 ppm/6 hrs/day for 2 weeks. At the<br/> end of treatment period, all males and females were sacrificed. During the test period, clinical signs,<br/> mortality, body weights, food consumption, hematology, serum biochemistry, and gross findings were<br/> examined. The mean body weights of the male 300 ppm group and the female 33 ppm or higher<br/> dose groups were significantly lower than those of the control group, respectively. The mean food<br/> consumption at male 300 ppm and female 100 and 300 ppm were significantly decreased compared<br/> with the controls. Some treatment-related serum biochemical changes, including decreased alkaline<br/> phosphatase at male 300 ppm and female 100 and 300 ppm, reduced total bilirubin at male 300<br/> ppm, and decreased alanine aminotransferase at female 300 ppm, were observed in a dose-dependent<br/> manner, but these findings were considered to be of no toxicological significance. There were no<br/> adverse effects on mortality, clinical signs, hematology, and necropsy findings in any treatment group.<br/> Based on these results, it was concluded that the 2-week repeated dose of dimethyl disulfide by inhalation<br/> resulted in suppressed body weight gain and decreased food consumption at the dose of male<br/> 300 ppm and suppressed or reduced body weight gain and decreased food consumption at the dose<br/> of female 33 ppm or higher. In the present experimental conditions, the no-observed-adverse-effect<br/> level (NOAEL) was considered to be 100 ppm/6 hrs/day for male rats and below 33 ppm/6 hrs/day<br/> for female rats.
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