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최상욱(Sang Wook Choi),한남익(Nam Ik Han),이창돈(Chang Don Lee),정진우(Jin Wu Jeong),박두호(Doo Ho Park),김부성(Boo Sung Kim),임병욱(Byung Uk Lim),김금룡(Gum Ryong Kim) 대한내과학회 1991 대한내과학회지 Vol.40 No.1
N/A The histocompatibility system and its association with chronic viral liver diseases remain unexpiained, but they represent an important step forward in the searh for basic causes and mechanisms of the diseases. patients of chronic hepatitis B carriers (n =158) including asymptomatic hepatitis B carrier (n=17), chronic hepatitis (n=39), liver cirrhosis (n=57), and hepatocellular carcinoma (n=45) were examind to ascertain the genetic relationship between chronic hepatic diseases and histocompatibility antigen. Peripheral blood lymphocytes were seperated from whole blood by the Ficoll/hypaque gradient method. A total 71 histocompatibility antigens (class I antigens: 56, class II anrigens: 15) were analyzed by performing complement microlymphocytotoxicity test using Terasaki`s and Catholic Unversity Medical College tissue typing plate. HLA antigen frequencies were compared with those of 109 normal HBsAg negative controls. The following results were obtained: 1) Frequencies of HLA-A26, Bw46, Bw57, Cw6, Cw7, DRw8, and HLA-DRw52 antigens in chronic hepatitis patients were shown to be higher than those in the controls. Frequencies of HLA-Bw46, Bw57, Cw7, DRw8, DRw52, and DQw3 antigens in liver cirrhosis patients shown relatively more frequently than those in the controls. In patients with hepatocellular carcinoma, antigens of HLA-Bw46, Bw57, Cw7, and DRw53 were dominantly detected. 2) There was positive association with HLA-Bw46, Bw57, Cw7, DRw8, DRw52 and DRw53 in patients of chronic liver diseases. Further stusies may lead to better classifications of the diseases and to an increased understanding of basic biological processes, etiologies, and relationships between genetic and environmental susceptibility to chronic liver diseases.