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선상 태선에서 Calcineurin 억제제 국소 도포의 치료 효과
김건욱 ( Gun Wook Kim ),김수한 ( Su Han Kim ),진현우 ( Hyun Woo Chin ),서상희 ( Sang Hee Seo ),정도상 ( Do Sang Jung ),고현창 ( Hyun Chang Ko ),김문범 ( Moon Bum Kim ),권경술 ( Kyung Sool Kwon ) 대한피부과학회 2009 大韓皮膚科學會誌 Vol.47 No.10
Background: Lichen striatus is a well-known, acquired, self-healing, linear inflammatory dermatosis. The therapeutic approach that is usually adopted is topical steroid, even though the prolonged use of this may lead to several side-effects, and particularly cutaneous atrophy. Objective: The purpose of this study was to evaluate the efficacy of topical calcineurin inhibitors for the treatment of lichen striatus. Methods: Twenty nine patients received topical application of calcineurin inhibitors twice a day up to the marked disappearance of the cutaneous lesions. Results: Six (20.7%) of 29 patients achieved a complete response after a mean treatment period of 2.5 months. A good response was observed in 8 patients (27.6%) and a partial response was seen in 8 patients (27.6%). Of the 29 patients, 22 patients (75.9%) had more than a 50% response without any severe adverse effects. No significant differences in the therapeutic responses were found with regard to the patients` ages, the duration of the disease and the length of the treatment periods. Conclusion: Our results show that topical calcineurin inhibitors may well represent a useful therapeutic alternative for the treatment of lichen striatus. (Korean J Dermatol 2009;47(10):1135∼1140)
김건욱 ( Gun Wook Kim ),서성원 ( Sung Won Suh ),고현창 ( Hyun Chang Ko ),김문범 ( Moon Bum Kim ),권경술 ( Kyung Sool Kwon ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.8
Granulomatous mycosis fungoides is a rare type of cutaneous T-cell lymphoma. The patients with this illness do not present with distinct clinical findings, so the diagnosis depends on the demonstration of a malignant lymphoid infiltration in combination with a granulomatous tissue reaction. A 38-year-old woman presented with erythematous to purple-colored, focally atrophic, scaly plaques on the right inguinal area and diffuse erythematous scaly patches and multiple erythematous papules on the trunk. The histopathological findings showed non-necrotizing granulomatous infiltrates admixed with an atypical lymphocytic component and epidermotropism. Herein, we report a case of granulomatous mycosis fungoides. (Korean J Dermatol 2009;47(8):967~970)
김건욱 ( Gun-wook Kim ) 한국피부장벽학회 2017 한국피부장벽학회지 Vol.19 No.1
The most important function of the skin is to form a barrier between the organism and the environment. The skin barrier prevents excessive water loss and the entry of harmful substances from the environment. The stratum corneum barrier is composed of corneocytes and intercellular lipids, cholesterol, free fatty acids, and ceramides. Keratins and cornified envelope proteins are important for the mechanical stability of the corneocytes. The cornified envelope protein involucrin binds ceramides covalently, forming a backbone for the subsequent attachment of free ceamides. Experimental barrier disruption increases epidermal lipids and changes in epidermal differentiation. The signals for barrier recovery are cytokines and the calcium ion gradient. Herein, the mechanisms for the regulation of the barrier homeostasis are discussed.
김건욱 ( Gun Wook Kim ),김훈수 ( Hoon Soo Kim ),김수한 ( Su Han Kim ),정도상 ( Do Sang Jung ),고현창 ( Hyun Chang Ko ),김문범 ( Moon Bum Kim ),권경술 ( Kyung Sool Kwon ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.1
Background: Hand eczema is a common skin disease in the general population. The etiology of hand eczema is obscure and many causative factors have been proposed. However, there are only a few reported studies of the relevance of contact allergy in hand eczema. Objective: The purpose of this study was to evaluate the diagnostic value of the patch test for patients with hand eczema. Methods: We analyzed the clinical characteristics and the results of the patch tests of the 37 patients with hand eczema and we then compared these with the clinical subtypes. Results: 26 patients (70.3%) showed a positive test to one or more allergens. The common allergens were nickel sulfate (35.1%), mercury ammonium chloride (21.6%), and cobalt chloride (18.9%). The positive rates for a patch test were 82.4% for the vesicular form, 77.8% for the fissured form, 20.0% for the hyperkeratotic form and 66.7% for pompholyx, respectively. We found more significant improvement of the clinical symptoms in the vesicular group (57.1%) than that in the non-vesicular group (9.3%) after avoiding the verified allergens. Conclusion: This study shows that the patch test is a useful tool for the detection of contact allergens and it must be performed for the patients with hand eczema, and especially for those patients with the vesicular type. (Korean J Dermatol 2010;48(1):26∼32)
이원구 ( Won Ku Lee ),김건욱 ( Gun Wook Kim ),문제호 ( Je Ho Mun ),송마가렛 ( Margaret Song ),김훈수 ( Hoon Soo Kim ),고현창 ( Hyun Chang Ko ),김병수 ( Byung Soo Kim ),김문범 ( Moon Bum Kim ),김원정 ( Won Jeong Kim ) 대한피부과학회 2015 대한피부과학회지 Vol.53 No.10
Background: There are limited literatures regarding the clinical characteristics of the specific dermatoses of pregnancy, and their terminology has been confusing and misleading. A simplified classification is proposed with the new terminology ‘atopic eruption of pregnancy``, comprising several disease entities such as eczema of pregnancy, prurigo of pregnancy, and pruritic folliculitis of pregnancy. Objective: A clinical study was performed to determine the exact nature of atopic eruption of pregnancy in Korea. Methods: We retrospectively reviewed the medical records of 75 patients who were diagnosed and reclassified as atopic eruption of pregnancy at Pusan National University Hospital. Results: Among 121 patients with the specific dermatoses of pregnancy, 75 (62%) were diagnosed with atopic eruption of pregnancy. The most affected sites were the flexural surfaces of the neck and extremities, followed by the abdomen and back. The mean gestational age was 18.5 weeks. In 92% of cases, atopic eruption of pregnancy started during the 1st and 2nd trimesters of pregnancy. Major fetal problems were not seen. Atopic disease was observed in 26 (34.7%) patients. Total serum IgE levels were elevated in 10 (50%) patients among the 20 patients who were tested for IgE levels. Forty-four (58.5%) patients improved after delivery, and atopic eruption of pregnancy recurred after delivery in 6 (8%) patients. Conclusion: The characteristics of AEP in Korea were mostly similar to those of AEP in Western countries. However, AEP in Korea seems to show a poor prognosis and be refractory to treatment compared to that of Western countries.
Case Report : Megalencephaly-capillary Malformation Syndrome
박성민 ( Sung-min Park ),김건욱 ( Gun-wook Kim ),조현호 ( Hyun-ho Cho ),김원정 ( Won-jeong Kim ),문제호 ( Je-ho Mun ),송마가렛 ( Margaret Song ),김훈수 ( Hoon-soo Kim ),김병수 ( Byung-soo Kim ),김문범 ( Moon-bum Kim ),고현창 ( Hyun 대한피부과학회 2015 大韓皮膚科學會誌 Vol.53 No.7
Megalencephaly-capillary malformation syndrome is a disorder characterized by megalencephaly or hemimegalencephaly, focal or generalized somatic overgrowth, and vascular malformations. Other characteristic features are neonatal hypotonia, hydrocephalus, developmental delay, syndactyly/polydactyly, frontal bossing, and connective tissue dysplasia. Previously reported patients exhibit wide phenotypic variability in clinical and neuroradiological findings. Differential diagnosis may be challenging for clinicians due to other similar neurocutaneous syndromes. Herein, we report an 11-month-old male infant that presented with extensive, diffuse, reticulated, erythematous patches on his face, trunk, and extremities. Physical examination revealed an increased head circumference (>97 percentile), frontal bossing, hypertrophy of the right arm and leg, and syndactyly on both feet. Borderline developmental delay was identified, and magnetic resonance imaging of the brain revealed an enlarged right cerebral hemisphere and non-obstructive ventriculomegaly. To our knowledge, this is the first report of megalencephalycapillary malformation syndrome in Korean literature. (Korean J Dermatol 2015;53(7):546∼551)
김정민 ( Jeong Min Kim ),김건욱 ( Gun Wook Kim ),문제호 ( Je Ho Mun ),송마가렛 ( Margaret Song ),김훈수 ( Hoon Soo Kim ),김병수 ( Byung Soo Kim ),김문범 ( Moon Bum Kim ),고현창 ( Hyun Chang Ko ) 대한피부과학회 2014 大韓皮膚科學會誌 Vol.52 No.8
Background: Periocular dermatitis (PD) is a common condition and can be classified as either allergic or non-allergic. Because the periocular region is one of the most sensitive areas of the skin, contact with any environmental or therapeutic allergen may give rise to dermatitis. Objective: The aim of this study was to investigate the clinical usefulness of patch testing to determine sensitivity to contact allergens in PD patients. Methods: Patch testing was conducted in 29 PD patients using the T.R.U.E. testⓡ at Pusan National University Hospital. We examined the results of patch testing, the probable cause of PD, and the history of use of ophthalmic medication. Results: Contact hypersensitivity was detected using the T.R.U.E. testⓡ in 62.1% (18/29) of the patients, and contact hypersensitivity to specific ophthalmic medications was observed in 33.3% (3/9) of the patients with a history of using ophthalmic medication. Conclusion: We suggest that patch testing can be utilized to elucidate the relevant contact allergen in patients with PD. Patch testing with specific ophthalmic medications is valuable to determine allergic reactions in patients who have used ophthalmic medications. (Korean J Dermatol 2014;52(8):548∼553)