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류마티스 관절염과 HLA-B27과의 연관성에 관한 연구
고희관 ( Hee Kwan Koh ),오광택 ( Kwang Taek Oh ),송용호 ( Yong Ho Song ),정자헌 ( Ja Hun Jung ),김태환 ( Tae Hwan Kim ),김동욱 ( Dong Yook Kim ),전재범 ( Jae Bum Jun ),정성수 ( Sung Soo Jung ),이인홍 ( In Hong Lee ),배상철 ( Sang 대한류마티스학회 1996 대한류마티스학회지 Vol.3 No.1
Objective: In rheumatoid arthritis(RA) patients, HLA-B27 has been mainly found with the same frequency as in the normal population. An increased frequency of HLA-B27 in RA has, however, repeatedly been found in northern Sweden and in Filand. The results concerning the association of HLA-B27 to the outcome of the disease have been contradictory in RA. In RA, the presence of HLA-B27 has shown to be a prognostic index for cervical spine subluxation. There has been no report regarding the association between RA and HLA-B27 in the Korean population. Methods: 188 patients with RA were randomly selected from the patients who were diagnosed at Rheumatism Center of Hanyang University Hospital from October 1994 to June 1995 to establish the frequency of HLA-B27 in RA and to investigate the possible influence and prognostic significance on clinical outcome including atlantoaxial subluxations. Results: The results were as follows: 1) HLA-B27 was present in 12.2% of the RA patients studied. The relative risk (RR) and etiologic fraction (EF) of HLA-B27 were 5.99 and 0.1019 respectively. 2) The rheumatoid factor was positive in 79.8% of the total patients, 73.9% in HLA-B27 positive patients, and 80.6% in HLA-B27 negative patients. HLA-B27 was not associated with the presence of rheumatoid factor in this study. 3) HLA-B27 was not associated with the duration of morning stiffness, Ritchie index, extraarticular manifestations, the number of swollen joints, ARA functional class, ESR. C-reactive protein, or hemoglobin. HLA-B27 was not associated with the positivity of ANA and antiperinuclear factor. 4) HLA-B27 was not associated with the positive rate of erosion and Steinbrocker class in peripheral joints. 5) Atlantoaxial subluxation was present in 13% of HLA-B27 positive patients and 17% of HLA-B27 negative patients. The involvement of atlantoaxial joint including narrowing of lateral facet joints was 26.1% in HLA-B27 positive patients and 20.6% in HLA-B27 negative patients. Subaxial subluxation was presented in only 1 case in HLA-B27 negative group of total patients. HLA-B27 was not associated with the cervical changes in RA. Conclusions: An increased freuency of HLA-B27 in RA patients was significantly found in Korea (RR=5.99, EF=0.1019). However, patients with HLA-B27 had a similiar clinical profile to patients without HLA-B27 and HLAB27 positivity did not further contribute to the severity with respect to clinical and laboratory variables or to radiological progression in peripheral joints or cervical spine.
고희관 ( Hee Kwan Koh ),안명주 ( Myung Ju Ahn ),김태환 ( Tae Hwan Kim ),이은영 ( Eun Young Lee ),유태석 ( Tae Seok Yoo ),이제경 ( Je Kyung Lee ),장대국 ( Dae Kook Chang ),심승철 ( Seung Cheol Shim ),전재범 ( Jae Bum Jun ),정성수 ( 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.1
Objective: Rheumatoid arthritis(RA) is a disease characterized by infiltration of mononuclear cells into synovium and abnormal proliferation of synovial cells leading to pannus formation, which shows tumor-like growth. To determine whether telomerase is activated in RA and telomerase might be involved in the pathogenesis of RA, we measured telomerase activity in patients with RA. Methods: Telomerase activity was measured by using TRAP(telomeric repeat amplification protocol) assay in synovial tissues obtained from 17 patients with RA and 10 patients with osteoarthritis(OA), in cultured synovial cells from 4 patients with RA and 2 patients with OA, and in extracts of mononuclear cells from synovial fluid of 6 patients with RA. Results: Twelve of synovial tissues from 17 patients with RA(70.6%) showed telomerase activity, where three of synovial tissues from 10 patients with OA(30%) showed telomerase activity with low activity. Telomerase activity was detected in two of the cultured synoviocytes from 4 patients with RA(50%), but synoviocytes from patients with OA did not reveal any telomerase activity, if any. Telomerase acivity was detected in mononuclear cells extracted from synovial fluid of all patients with RA. Conclusion: Telomerase activity is highly positive in RA synovial tissues than OA synovial tissues and in RA synoviocytes as in mononuclear cells from synovial fluid. Taken together, these findings indicate that telomerase may playa role in the pathogenesis of RA.
윤형란 ( Hyun Ran Yun ),정성수 ( Sung Soo Jung ),고희관 ( Hee Kwan Koh ),유태석 ( Tae Seok Yoo ),이제경 ( Je Kyung Lee ),황관표 ( Kwan Pyo Hong ),김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),이인홍 ( In Hong Lee ),배상철 ( Sang 대한류마티스학회 1997 대한류마티스학회지 Vol.4 No.2
SAPHO(synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome designates a group of articular and osseous manifestations frequently combined with skin disorders. It`s fundamental component is inflammatory, pseudoinfectious, and sterile osteitis. The anterior chest wall is the most frequent localization and all the components of this structure may be involved. Palmoplantar pustulosis, psoriasis, acne conglobata, acne ulcerans, acne fulminans, pyoderma gangrenosum can be associated with the characteristic bone lesions. We report two cases of SAPHO syndrome: A 40-year-old female presented with both buttock pain with hyperostosis, costochondritis, synovitis and pustulosis palmaris and a 23-year-old male presented with migrating polyarthritis with costochondritis, synovitis, acne, Pustulosis.
전신성 홍반성 루푸스에서 발생한 만성 결절성 통풍 2예
조영신 ( Young Shin Cho ),양종태 ( Jong Tae Yang ),고희관 ( Hee Kwan Koh ) 대한류마티스학회 2001 대한류마티스학회지 Vol.8 No.4
Gout and systemic lupus erythematosus(SLE) are relatively common diseases in rheumatism. But the case of coexistent gout and SLE is extremely rare. The rarity is that may be due to misdiagnosis and disparity of the epidemiology. It is suggested that immulonogic milieu in SLE and therapy for SLE may have a negative effect on the manifestations of gout. Especially, hyperuricemia that not caused by nephritis, renal failure, use of diuretics, alcohol drinking and other risk factors in premenopausal women is extremely rare. We experienced two cases of chronic tophaceous gout in female patients with SLE who did not have other hyperuricemic risk factors.
전재범 ( Jae Bum Jun ),유대현 ( Dae Hyun Yoo ),이은영 ( Eun Young Lee ),고희관 ( Hee Kwan Koh ),김태환 ( Tae Hwan Kim ),정자헌 ( Ja Hun Jung ),장대국 ( Dae Kook Chang ),배상철 ( Sang Cheol Bae ),최영길 ( Yong Keel Choi ),김성윤 ( 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.1
Objective: Bucillamine(BUC) is a new disease-modifying anti-rheumatic drug, which is structurally similar to D-penicillamine. In type II collagen induced arthritis, BUC inhibited the proliferation of synovial lining cells. This study was designed to demonstrate whether BUC inhibits TNF-α-induced synovial cell proliferation or NF-κB activation in cultured synovial cells from patients with RA. Methods: The non-radioactive, colorimetric assay system was applied to cell proliferation assay. The activation of NF-κB was assessed by electrophoretic mobility shift assay. Results: Synovial cells proliferated in a dose-dependent manner in the presence of varying concentrations of TNF-α. The proliferative activity of synovial cells was inhibited in a dose-dependent fashion by BUC. Incubation of synovial cells with 20ng/ml TNF-α resulted in the appearance of shifted NF-κB bands. Control experiments indicated that these bands were eliminated by a 100-fold excess of unlabeled NF-κB probe, but not by a 100-fold excess of unrelated oct-1 probe. These findings represented that the binding between NF-κB and labeled probe is specific. Pretreatment with 30μg/ml BUC for 2 hours partially inhibited TNF-α-induced NF-κB activation in synovial cells. Conclusion: BUC inhibited the activation of NF-κB, which further explains the mechanism of action of this drug. Further studies on mechanism of inhibitory action of BUC on NF-κB activation are considered necessary.
이오영 ( Oh Young Lee ),김태환 ( Tae Hwan Kim ),고희관 ( Hee Kwan Koh ),이제경 ( Je Kyung Lee ),유태석 ( Tae Seok Yoo ),장대국 ( Dae Kook Chang ),심승철 ( Seung Cheol Shim ),전재범 ( Jae Bum Jun ),정성수 ( Sung Soo Jung ),이인홍 ( 대한류마티스학회 1998 대한류마티스학회지 Vol.5 No.1
Objectives: In the connective tissue disease patients, esophageal dysfunction is often closely associated with the presence of Raynaud`s phenomenon. But there are no previous reports concerning the values of esophageal manometry in the connective tissue disease with Raynaud`s phenomenon in Korea. Therefore, we performed this study to evaluate esophageal function in connective tissue disease with Raynaud`s phenomenon. Methods: Total 86 subjects were employed in this study including 30 normal control group, 14 mixed connective tissue disease(MCTD), 21 systemic sclerosis, 16 systemic lupus erythematosus(SLE), and 5 Raynaud`s phenomenon only. In each subject, esophageal manometric study was performed with lower compliance capillary infusion system. Results: The mean age(±SD) of patients and controls were as follows: MCTD 34.1(±8.9), systemic sclerosis 44.9(±9.3), SLE 32.1(±7.9), and normal controls 31.9(±5.3). All patients with MCTD and systemic sclerosis had Raynaud`s phenomenon. Twelve out of 14 patients with MCTD, 17 out of 21 patients with systemic sclerosis, were abnormal in esophageal manometry. Nine out of 16 SLE had Raynaud`s phenomenon. Among 9 SLE with Raynaud`s phenomenon, 5 patients(55.5%) were abnormal in esophageal manometry, and among 7 SLE without Raynaud`s phenomenon, 2 patients(28.6%) were abnormal in esophageal manometry. Among 5 patients with Raynaud`s phenomenon, 3 patients were abnormal in esophageal manometry. Abnormal esophageal manometry finding is more common in the connective tissue disease patients with Raynaud`s phenomenon compared with the patients without Raynaud`s phenomenon (P=0.0219). Conclusions: Abnormal esophageal manometry finding is more common in the connective tissue disease patients with Raynaud`s phenomenon compared with the patients without Raynaud`s phenomenon.