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Lansoprazole 근간 3제요법과 병합 투여된 Ecabet Sodium이 Helicobacter pylori 제균율에 미치는 효과
서정연 ( Jung Yeon Seo ),김민정 ( Min Jeong Kim ),고규한 ( Kyu Han Ko ),김동현 ( Dong Hyun Kim ),임대섭 ( Dae Seop Lim ),전해리 ( Hae Ri Chon ) 대한내과학회 2011 대한내과학회지 Vol.80 No.5
Background/Aims: Ecabet sodium is used for treating gastric ulcers and gastritis. It exhibits a bactericidal effect against Helicobacter pylori by inhibiting bacterial urease activity. Thus, ecabet sodium has been suggested to improve the efficacy of the H. pylori eradication in patients with peptic ulcers. The aim of this study was to compare the H. pylori eradication rate of lansoprazole-based triple therapy versus lansoprazole-based triple therapy plus ecabet sodium. Methods: The subjects consisted of 363 H. pylori-positive patients who had undergone eradication therapy from February 2007 to February 2010. In total, 363 patients with H. pylori-positive peptic ulcer disease or symptomatic erosive gastritis received LAC (lansprazole 30mg b.i.d., amoxicillin 1.0g b.i.d., clarithromycin 500mg b.i.d.) or LACE (lansoprazole 30mg b.i.d., amoxicillin 1.0g b.i.d., clarithromycin 500mg b.i.d., ecabet sodium 1g b.i.d.) for 1 week. Successful eradication was defined as a negative 13Curea breath test 4-5 weeks after treatment completion. Results: H. pylori eradication rates were 81.4% (166/204) in the LAC group and 86.2% (137/159) in the LACE group (p=0.159). No significant difference in eradication was observed. No significant difference was observed in the side effects experienced by the patients in the two treatment groups. Conclusions: Our results suggest that adding ecabet sodium did not improve the H. pylori eradication rate significantly in standard lansoprazole-based triple therapy for H. pylori.
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