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폐결핵에서 객담 결핵균 중합효소 연쇄반응 검사의 누적 양성율
경태영(Tae Young Kyong),이준호(Jun Ho Lee),채경수(Gyeong Soo Chae),김동규(Dong Kyu Kim),모은경(Eun Kyung Mo),박명재(Myung Jae Park),이명구(Myung Goo Lee),현인규(In Gyu Hyun),남기형(Ki Hyung Nam),이경화(Kyung Wha Lee),정기석(Ki Suck J 대한내과학회 1998 대한내과학회지 Vol.55 No.6
Objectives: The conventional methods such as smear or culture of Mycobacteria have been proved either low sensitivity and specificity or time-consuming. Polymerase chain reaction(PCR) is a rapid and sensitive alternative method to diagnose mycobacterial infection. We investigated the positive rate of sputum PCR for Mycobacterium tuberculosis by consecutive tests for its application in clinical practice. Methods: Sputum AFB smear, culture and serial AFR PCR test were performed in all patients who were suspected of pulmonary tuberculosis, Among them, 128 patients with positive sputum PCR test were enrolled from January 1996 through March 1997. The diagnostic criteria of pulmonary tuberculosis were sputum AFB smear positive, culture positive or pathologically proven granuloma. TB-CR TM kit (Bioneer, seoul, Korea), which amplifies insertion sequence(IS6110) of Mycobacterium tuberculosis complex, was used for sputum AFB PCR. Results: Of 128 patients, active pulmonary tuberculosis were 107 (male:74, female:33, mean age:48.9 year). Cumulative positive rate of sputum AFR PCR test was 89% at 1st test, 95% at 2nd test, 98% at 3rd test and 100% at 4th test. The sensitivity of sputum PCR, smear and culture was 98.0%(105/107), 85.0%(91/107) and 82.8%(77/107), respectively. The positive predictive value of sputum PCR was 83.6%(107/128). There were 21 patients who showed positive PCR test did not meet the diagnostic criteria of active tuberculosis. They had old tuberculosis with destroyed lung, history of anti-tuberculous medication(9/21), extrapulmonary tuberculosis (6/21) and other diseases(6/21). Conclusion: Sputum PCR test is a sensitive diagnostic tool in early diagnosis of pulmonary tuberculosis when it has been performed serially, we recommend at least 2 consecutive PCR test to achieve the sensitivity of 95%.