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1LC-3 Polymers and Nanocarriers for Intracellular Drug Delivery
강한창 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
Drug delivery systems (DDS) have been explored as an option for treatment of diverse diseases. Various carriers including polymers, lipids and natural materials have been developed to enhance drug efficacy and minimalize side effect of drugs. However, diverse extra- or intracellular barriers such as non-specific interaction, the plasma/nuclear membrane, and the endo/lysosomes often reduce drug efficacy of DDS. Among them, the endo/lysosomes are one of the obstacles for developing effective DDS because almost nano-sized carriers use endocytosis pathways for cellular internalization and should be escaped from the endo/lysosomes to reach target subcellular organelles. Thus, the effectiveness and functions of new endosomolytic molecules and polymers using a model gene delivery system will be introduced.
Mitochondria-targeting theranostics
강한창 한국생체재료학회 2018 생체재료학회지 Vol.22 No.4
Background: Interest in subcellular organelle-targeting theranostics is substantially increasing due to the significance of subcellular organelle-targeting drug delivery for maximizing therapeutic effects and minimizing side effects, as well as the significance of theranostics for delivering therapeutics at the correct locations and doses for diseases throughout diagnosis. Among organelles, mitochondria have received substantial attention due to their significant controlling functions in cells. Main body: With the necessity of subcellular organelle-targeting drug delivery and theranostics, examples of mitochondria-targeting moieties and types of mitochondria-targeting theranostics were introduced. In addition, the current studies of mitochondria-targeting theranostic chemicals, chemical conjugates, and nanosystems were summarized. Conclusion: With the current issues of mitochondria-targeting theranostic chemicals, chemical conjugates, and nanosystems, their potentials and alternatives are discussed.