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Helicobacter pylori감염증에서 Toll-like receptor4 발현억제에 의한 clarithromycin의 염증조절 작용
박준용 ( Park Jun Yong ),한동수 ( Han Dong Su ),표은주 ( Pyo Eun Ju ),강정옥 ( Kang Jeong Og ),김학양 ( Kim Hag Yang ),함준수 ( Ham Jun Su ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> Toll-like receptor4는 그램 음성균에서 생성되는 리포다당질을 인지하여 염증을 유발하는 과정에 중요한 역할을 담당한다. Helicobacter pylori감염증에서도 위 상피세포와 점막하 염증세포에서 TLR4의 작용과 NFkB 활성화에 의한 염증반응이 관찰된다. Macrolide계열 항생제는 여러 종류의 만성 염증 질환에서 사용되고 있는데 질환의 병원균에 대한 항균작용과 함께 NFkB의 발현과 연관된 항 염증작용이 있는 것으로 알려
감염증에서 위점막의 Toll-like Receptor 4 발현
박준용 ( Joon Yong Park ),한동수 ( Dong Soo Han ),김보현 ( Bo Hyun Kim ),강은경 ( Eun Kyung Kang ),이영춘 ( Ying Chun Li ),이항락 ( Hang Lak Lee ),김진배 ( Jin Bae Kim ),손주현 ( Joo Hyun Sohn ),최호순 ( Ho Soon Choi ),강정옥 ( Ju 대한소화기학회 2003 대한소화기학회지 Vol.41 No.3
Background/Aims: Toll-like receptors (TLRs) represent a pattern recognition receptors with an ability of specific recognition of pathogens. TLRs appear to respond to pathogens and induce NF- kB activation. TLR2 and 4 seem to be related to the initiation of immune response against gram negative and positive bacteria. We investigated the effect of Helicobacter pylori (H. pylori) infection on the expression of TLRs on the gastric mucosa. Methods: For 35 endoscopic gastric mucosa samples, histologic grading of H. pylori infection and inflammatory cell infiltration were performed. The mRNA expression of TLR2, 3, and 4 was examined by RT-PCR. Immunohistochemistry demonstrated the distribution of TLR2 and 4 in gastric mucosal biopsies. Results: H. pylori positive gastric mucosa expressed higher TLR4/GAPDH ratio than H. pylori negative gastric mucosa (p=0.035), while no significant difference in the expression of TLR2 and 3 was detected (p=0.129, p=0.176). The severity of neutrophil infiltration showed a significant positive correlation with TLR4/GAPDH ratio (p=0.045, r=0.342). Immunohistochemistry using anti-TLR4 and anti-TLR2 antibody revealed the expression of TLR4 in the epithelial cells of H. pylori-infected gastric mucosa. Conclusions: H. pylori infection induces TLR4 expression in the human gastric epithelium, which suggests a certain role of TLR4 in the mucosal inflammatory reaction to H. pylori infection. (Korean J Gastroenterol 2003;41:171-176)
한국인 십이지장 궤양 환자에서 분리된 Helicobacter pylori균주의 약제 내성률
박경남,한동수,조윤주,강정옥,손주현 대한소화기학회 1997 대한소화기학회지 Vol.29 No.6
Background/Aims: Clarithromycin and metronidazole are most frequently used antibiotics for eradication of H. pylori infection. Primary resistance to metronidazole is high in some populations. Success of H. pylori eradication therapy may be limited by antibiotic resistance. In this study we evaluate primary resistance of clarithromycin and metronidazole in Korean duodenal ulIcer patients. Methods: H. pylori isolated from gastric biopsies of patients with newly diagnosed duodenal ulcer were cultured in egg yolk emulsion agar, brain heart infusion broth and tested for clarithromycin and metronidazole resistance by microdilution broth, E test(AB Biodisk, Solna, Sweden) and disk diffusion methods. The breakpoint MIC for Spg/mL in metronidazole, 2pg/mL and 12mm in clarithromycin. The patients with previous trip]e therapy were excluded. Results: One of 40(2%) isolates was resistant to clarithromycin in microdilution broth, E test, and disk diffusion methods. Metronidazole resistance were 22/40(55%) in microdilution rnethod(9/22 had MICs w 32㎍/mL), 26 of 40(65%) in E test(19/26 had MICs $gt;32㎍/mL), 25 of 40(62.5%) in disk diffusion methods. Age, sex and smoking did not influence on the results. Conclusions: Metronidazole resistance is high(55%) in Korea, but clarithromycin resistance is relatively low, therefore proper antimicrobial treatrnent should be considered in regard to antibiotic susceptibility test to H. pylori.