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- 저자 : 강승이(Seung Yi Kang) (검색결과 3 건)
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강승이(Seung Yi Kang),오수아(Soo A Oh),이학성(Hak Sung Lee),한성태(Sung Tai Han),신차균(Cha-Gyun Shin) 대한약학회 2005 약학회지 Vol.49 No.3
Human foamy virus (HFV) integrase mediates integration of viral c-DNA into cellular DNA. In this process, HFV integrase recognizes its own viral DNA specifically and catalyzes insertion of viral c-DNA. In order to study catalytic domains and residues, three deletion mutants and two point mutants of HFV integrase were constructed and analyzed with respect to enzymatic activities. The C-terminal deletion mutant showed decreased enzymatic activities while the N-terminal deletion mutant lost the activities completely, indicating that the N-terminal domain is more important than the C-terminal domain enzymatic reaction. The point mutants, in which an aspartic acid at the 164th position or a glutamic acid at the 200th position of The HFV integrase protein was changed to alanine, lost the enzymatic activities completely. However, they results suggest that the aspartic acid and glutamic acid at the respective 164th and 200th positions are catalytic residues for enzymatic reaction.
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오수아(Soo A Oh),강승이(Seung Yi Kang),한성태(Sung Tae Han),안덕근(Dog Gn An),신차균(Cha-Gyun Shin) 대한약학회 2006 약학회지 Vol.50 No.2
Human foamy virus (HFV) integrase mediates integration of viral c-DNA into cellular DNA. In this process, HFV preintegration complex (PIC) in which integrase is a key component moves to nuclei of the infected cells and leads to integration of viral DNA to the cellular genome, which is essential in viral life cycle. In general nuclear localization signals (NLS) have been suggested to be involved in localizing retroviral PIC to muclei, but the mechanisms for nuclear localization of the HFV PIC remains unclear. To functionally identufy the NLS of HFV integrase, various subdomains of the protein were expressed as GFP fusions and fusions and their subcellular locations were analyzed with comfocal laser scanning microscopy. Wild type HFV integrase was karyophilic by targeting the fusion protein to nuclei of the COS-1 and 294T cells. Our results showed that strong NLS of HFV integrase was mapped to the C-terminal regions. In addition the karyophimic properties of N-ter- minal and central regions are not individually strong enough to direct localization of the fusion proteins to nuclei, but their cooperative activity for nuclear inport was comfirmed.
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방기진(Bang Ki-Jin),이병희(Lee Byung-Hee),강승이(Kang Seung-Yi),제해성(Je Hae-Seong) 대한건축학회 2010 대한건축학회논문집 Vol.26 No.9
The goal of this study is to development Quality-of-Life Assessment Tool (hereinafter called as "SusB-QOL") that focused on the physical residential environment, and based on Green Growth approach. The process of research is as follow; 1) Set data-pool of Quality-of-Life Assessment Index by documented studies. 2) Derive 4 main issues through Green Growth-based approaches. 3) Derive 25 detailed relevant items through questionnaire survey. 4) Develop assessment system to design a computer program. 5) Application of SusB-QOL is to real Building in Korea. The main results of this study is as follow; 1) The 4 Main issues of SusB-QOL is 'Health', 'Amenity', 'Safety', and 'Convenience'. 2) The most important factor of the physical residential environment in Korea is the 'Noise' and 'Water quality' among 25 detailed relevant items of SusB-QOL. 3) Index of P-Residential-Complex (in Bungdang, Korea) is 75 percent point, and the most improvable item is 'window area ratio and view'.
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