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RISS 인기검색어
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- 저자 : 강성돈(Seong Don Kang) (검색결과 3 건)
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Contractile Effect of Ultraviolet Light on Isolated Thoracic Aortae of Rats
백영홍,강성돈,강정채,Baik, Yung-Hong,Kang, Seong-Don,Kang, Jung-Chaee The Korean Society of Pharmacology 1993 대한약리학잡지 Vol.29 No.1
Ultraviolet light radiation (UVR) did not affect resting tension of isolated thoracic aortae of rats. In aortic rings contracted with phenylephrine, however, UVR produced contractile and relaxant responses in preparations with and without endothelium, respectively. The contractile response was dependent upon the duration $(10{\sim}320\;sec)$ of irradiation, while the relaxation was not. UVR-induced contractions in endothelium-intact rings were significantly potentiated by increasing the concentrations of phenylephrine from $10^{-7}M$ to $10^{-5}M$, and also by addition of $10^{-6}M$ acetylcholine, $10^{-7}M$ isoproterenol and $3.5{\times}10^{-8}M$ nitroglycerine. However, addition of $10^{-6}M$ phentolamine, or $10^{-7}M$ to $10^{-6}M$ LY83583 inhibited the contraction or reversed the contraction to a relaxation. In endothelium-removed preparations the UVR-induced relaxation was attenuated by increasing concentractions of phenylephrine, and by addition of isoproterenol, nitroglycerin, phentolamine or LY83583. These results suggest that UVR produces contractile and relaxant responses in rat thoracic aortae with and without endothelium, respectively, and that the contractile effect results from the inhibition of endothelium-derived relaxing factor (EDRF) release by UVR the inhibition of and/or is in part re-lated to some endothelium-derived contractile factors (EDCFs). 자외선조사는 흰쥐흉부대동맥의 휴지기장력에 거의 영향을 미치지 못했으나, phenylephrine으로 수축된 표본에서는 자외선조사로 내피세포가 존재하면 수축반응을, 내피세포가 제거되면 이완반응이 나타났다. 이 수축반응은 조사시간의 길이($10{\sim}320$초)에 비례하여 증가하였으나 이완반응은 그렇지 못하였다. 내피세포 존재표본에서 자외선의 수축반응은 phenylephrine농도의 증가($10^{-7}{\sim}10^{-5}M$) 그리고 $acetylcholine(10^{-6}M)$, $isoproterenol(10^{-7}M)$ 및 $nitroglycerin(3.5{\times}10^{-8} M)$의 추가투여시 크게 강화되었다. 그러나 $phentolamine(10^{-6}M)$ 또는 $LY83583(10^{-7},10^{-6}M)$의 추가투여시에는 자외선 수축반응이 억제 또는 이완반응으로 역전되었다. 내피세포 제거표본에서의 자외선 이완반응은 phenylephrine농도의 증가 그리고 isoproterenol, nitroglycerine, phentolamine 및 LY83583의 추가투여시 유의하게 감약되었다. 이상의 성적은 흰쥐 적출 흥부대동맥에서 자외선조사는 내피세포 존재유무에 따라 수축과 이완반응이 각각 나타나며, 수축반응은 자외선에 의한 EDRF 유리억제 또는 부분적으로 어떤 EDCF와도 관련이 있음을 시사하고 있다.
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백영홍(Yung Hong Baik),강성돈(Seong Don Kang),강정채(Jung Chaee Kang) 대한약리학회 1993 대한약리학잡지 Vol.29 No.1
자외선조사는 흰쥐흉부대동맥의 휴지기장력에 거의 영향을 미치지 못했으나, phenylephrine으로 수축된 표본에서는 자외선조사로 내피세포가 존재하면 수축반응을, 내피세포가 제거되면 이완반응이 나타났다. 이 수축반응은 조사시간의 길이(10 ~ 320초)에 비례하여 증가하였으나 이완반응은 그렇지 못하였다. 내피세포 존재표본에서 자외선의 수축반응은 phenylephrine농도의 증가(10<sup>-7</sup> ~ 10<sup>-5</sup>M) 그리고 acetylcholine(10<sup>-6</sup>M), isoproterenol(10<sup>-7</sup>M) 및 nitroglycerin(3.5 × 10<sup>-8</sup> M)의 추가투여시 크게 강화되었다. 그러나 phentolamine(10<sup>-6</sup>M) 또는 LY83583(10<sup>-7</sup>,10<sup>-6</sup>M)의 추가투여시에는 자외선 수축반응이 억제 또는 이완반응으로 역전되었다. 내피세포 제거표본에서의 자외선 이완반응은 phenylephrine농도의 증가 그리고 isoproterenol, nitroglycerine, phentolamine 및 LY83583의 추가투여시 유의하게 감약되었다. 이상의 성적은 흰쥐 적출 흥부대동맥에서 자외선조사는 내피세포 존재유무에 따라 수축과 이완반응이 각각 나타나며, 수축반응은 자외선에 의한 EDRF 유리억제 또는 부분적으로 어떤 EDCF와도 관련이 있음을 시사하고 있다. Ultraviolet light radiation (UVR) did not affect resting tension of isolated thoracic aortae of rats. In aortic rings contracted with phenylephrine, however, UVR produced contractile and relaxant responses in preparations with and without endothelium, respectively. The contractile response was dependent upon the duration (10 ~ 320 sec) of irradiation, while the relaxation was not. UVR-induced contractions in endothelium-intact rings were significantly potentiated by increasing the concentrations of phenylephrine from 10<sup>-7</sup>M to 10<sup>-5</sup>M, and also by addition of 10<sup>-6</sup>M acetylcholine, 10<sup>-7</sup>M isoproterenol and 3.5 × 10<sup>-8</sup>M nitroglycerine. However, addition of 10<sup>-6</sup>M phentolamine, or 10<sup>-7</sup>M to 10<sup>-6</sup>M LY83583 inhibited the contraction or reversed the contraction to a relaxation. In endothelium-removed preparations the UVR-induced relaxation was attenuated by increasing concentractions of phenylephrine, and by addition of isoproterenol, nitroglycerin, phentolamine or LY83583. These results suggest that UVR produces contractile and relaxant responses in rat thoracic aortae with and without endothelium, respectively, and that the contractile effect results from the inhibition of endothelium-derived relaxing factor (EDRF) release by UVR the inhibition of and/or is in part re-lated to some endothelium-derived contractile factors (EDCFs).
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뇌동맥류 파열 환자에서 경두개도플러 검사의 임상적 의의
강성돈,문성근 圓光大學校 醫科學硏究所 1998 圓光醫科學 Vol.14 No.2
The velocity of blood flow through the middle cerebral artery was measured by transcranial doppler(TCD) in 51 patients with ruptured cerebral aneurysm. A correlation between measured maximal mean blood flow velocities and clinical factors including age, Hunt-Hess grade, Fisher grade, outcome was made. Furthermore, the author analyzed the relationship of TCD velocities with delayed ischemic neurologic deficit(DIND) to determine its reliability in given patients. An age-dependent reduction of the measured maximal mean velocities was found (r = -0.3683, p < 0.01). There was no significant difference between the flow velocities and evaluated clinical factors. When the flow velocities of 11 patients who developed DIND were compared with those of patients without deficits, no significant difference was seen. A significant increase in flow velocities in the day before the onset of DIND was found only in 3 of 11 cases. However, the rate of rise of flow velocities when studied daily, with a rate of > 50 ㎝/sec/day showed significant association with DIND(p<0.005, Fisher's exact test). These results suggest that high TCD flow velocities do not necessarily mean poor neurological status or dense subarachnoid hemorrhage, and a early steep rise of velocities during a day can predict the development of DIND.
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