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한국인 중등증-중증의 건선 환자에서 Guselkumab 치료의 효과 및 안전성에 관한 후향적 연구
오승민 ( Seung-min Oh ),강경원 ( Kyong-won Kang ),정기헌 ( Ki-heon Jeong ) 대한피부과학회 2023 대한피부과학회지 Vol.61 No.4
Background: Guselkumab is a monoclonal antibody that selectively targets interleukin-23 in the treatment of moderate to severe psoriasis. Several multinational clinical studies have reported on its efficacy. However, data on its efficacy and safety in Korean patients are currently very limited. Objective: This study evaluated the real-world efficacy and safety of guselkumab for treating patients with moderate to severe psoriasis in Korea. Methods: This single-center retrospective study included 40 patients treated with guselkumab for at least 12 weeks. Electronic medical records were reviewed for demographics, clinical characteristics, psoriasis area and severity index (PASI) score, body surface area, and adverse events. Results: The average PASI score at baseline (12.0±8.3) was significantly reduced to 3.3±3.8 at week 12, 2.2±2.2 at week 36, and 1.6±1.5 at week 52. At week 60, 93%, 60%, and 33% of patients achieved a PASI of 75, 90, and 100, respectively. Obesity, psoriatic arthritis, and previous biologics treatment experience were not significant indicators of guselkumab treatment efficacy. Seven patients reported adverse events; however, none discontinued guselkumab treatment. Conclusion: Guselkumab is an effective and safe treatment option for moderate to severe psoriasis in Korea. (Korean J Dermatol 2023;61(4):217∼225)
Norepinephrine과 AngiotensinⅡ의 혈압 상승작용에 대한 Diltiazem의 영향
高錫太,姜璟遠 조선대학교 약학연구소 1995 藥學硏究誌 Vol.17 No.1
This study was performed in order to investigated the effects of diltiazem, Ca^-2 channel blocker of benzothiazepine derivates, on the pressor actions of norepinephrine and angiotensinⅡ in rabbit Diltiazem inhibited the pressor actions of norepinephrine and angiotensinⅡ, but inhibition time by diltiazem was not continuous. In some other way, potentiated appearance of the pressor action of norepinephrine was exhibited 30∼40min after administration of diltiazem. Diltiazem inhibited both the pressor action of angiotensinⅡ and the potentiated pressor action of norepinephrine in rabbit pretreated with bethanidine, adrenergic neuronal blocking agent, and diltiazem diminished both the potentiated pressor action of norepinephrine and angiotensinⅡ in rabbit pretreated with chlorisondamine, ganglionic blocking agent.