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Paraquat 독성에 미치는 Glycyrrhizin의 효과
김연판(Yeon Pan Kim),홍사욱(Sa Uk Hong) 대한약학회 1988 약학회지 Vol.32 No.5
The herbicide, paraquat, has caused numerous poisonings in man and farm animals since its introduction. Although the lungs are the primary sites of toxicological effect, other organs are also damaged, such as liver, heart, and kidney. The biochemical mechanisms responsible for the toxicity of the herbicide are not clearly understood. The purpose of the present study was to determine the hepatotoxity of paraquat in rats and the effects of glycyrrhizin on the paraquat toxicity. The experimental results are the followings. 1.The values of serum AST, ALT, LDH, ALP, glucose, and cholesterol were significantly increased in the paraquat administered group. 2.The TBA values in serum and liver were also increased in the treated group. 3.The biochemical parameters of serum, such as AST, ALT, LDH and TBA values, were significantly low in the paraquat plus glycyrrhizin group in comparison with that of the paraquat only. The above results suggest that the glycyrrhizin, somehow, detoxify the hepa to toxicity of paraquat in the experimenta-animals.
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우리나라 一部 農村地域 家族計劃要員의 業務活動 및 事業實績에 關한 調査
金鍊判 서울大學校保健大學院 1972 公衆保健雜誌 Vol.9 No.2
In order to analyze the influence of Family Planning Workers on the Performance of the Family Planning Program in some Rural Areas of this country, survey were conducted in 12 townships in six counties for a one-week period from February 14 to 19, 1972 regarding the characteristics of the workers, characteristics of the Survey Areas, Target and Performance, number of Field Trip Days, and Activity Hours. Through the analysis of the resultant data, the following data have been obtained: 1) The average age of the Family Planning workers was 34.5 years. 2) 66.7 per cent of the workers were high school graduates. 3) As for the qualification of the workers, 50.0 per cent were aid nurses, 25.0 per cent were nurses, and 25.0 per cent were unlicensed workers. 4) 50.0 per cent of the workers had longivity of employment for five years or more. 5) The average density of population in the survey areas was 166.3 persons/㎢. 6) The average monthly number of Field Trip Days of the workers was 18.7 days. 7) The Family Planning Workers spent an average of 32 hours and 57 minutes for family planning activities each week. 8) Performance had postitive correlations with target by contraceptive method. It had postitive correlations with activity hours in case of Loop and contraceptive operations. However the number of Field Trip Days did not practically influence the Performance. On the basis of the above conclusion, the following recommendations are made: 1) In order to improve the aptitude of Family Planning Workers, a definite education and training system should be established. 2) In order to avoid superficial field trip activities, the morale of Family Planning Workers should be boosted. 3) Family Planning Workers should not be given other duty than that required for fulfilment of the family planning program. 4) For the qualitative improvement of the family planning program, excessive concentration on the achievement of Target should be avoided.
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Paraquat 毒性이 Mouse의 免疫反應에 미치는 影響
洪사욱,安榮根,金鍊判 원광대학교 식품약품안전성연구소 1992 食品藥品安全性硏究 Vol.5 No.-
In this paper we have reported that effect of the glycyrrhizin which contained main component in the licorice root on the immunotoxicity of paraquat. The paraquat and glycyrrhizin was administered intraperitoneally by injection in this experiment. Both of treated and untreated mice with paraquat were sensitized and challenged with s-RBC. The immune responses in the untreated mice were evaluated by antibody production, that is, arthus reation, delayed type hypersensitivity (DTH), rosette forming cell and macrophage activity. Although the immune responses in the group treated with paraquat decreased markedly, but in the group treated paraquat with glycyrrhizin significantly restored or potentially reduced humoral and cellular immune response and phagocyte activity.
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