http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Ethionme 長期技與가 生體에 미치는 影響에 關한 病理學的 硏究
鄭檜敎,洪錫宰 慶北大學校 醫科大學 1970 慶北醫大誌 Vol.11 No.1
The author studied morphological changes of various organs in albino rats of Sprague-Dowley strains, weighing between 170 to 230gm, fed with basal diet (18% protein)and additioal 0.25% D-L ethionine for 6 and 9 months, respectively; and the following results were obtained: 1) The main lesions in the liver were fatty changes, necrosis, regenerative changes, appearance of atypical liver cells and hepatoma-like nodule; and marked proliferations of oval ducts and connective tissue (cholangiofibrosis), and appearance of cholangioma-like nodules. Theses findings were more pronounced in 9-mon thgroup than in 6-month-group. 2) The tumor-like lesions have not been developed in 6-month-group while in 9-month-group, the hepatoma-like nodules were identified in 4 out of 24 albino rats (16.7%), and cholangioma-like nodules were noted in 10 out of 24 rats (42.7%). These tumor-like nodules showed malignant characteristics histologically but no evidence of biological malignancy such as distant metastases. 3) The 9-month-group showed marked shrinkage and fibrosis of glomeruli and necrosis of proximal convoluted tubules, and there was noted a mild degree of regenerative changes in tubular epithelium of the kidney. 4) The spleen showed atrophic changes in white pulp. The red pulp revealed a pulp cell hyperplasia and marked infiltration of plasmatoid cell. The lymphnodes showed atrophic changes of follicles and marked plasma cell infiltrations. 5) The testis showed marked atrophic changes in seminifernus tubules of 3 or 4 degree by Kaufman's grading. 6) The stmach revealed a definite degenerations of chief cells while the parietal cells were intact. The salivary gland and pancreas showed atrophic and destructive changes in acinar cells and intercalated ducts.