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        柴胡疏肝散 및 그 加味方이 생쥐의 膽石症에 미치는 影響

        安圭錫,崔昇勳,潘相勳 대한동의병리학회 1991 동의생리병리학회지 Vol.6 No.-

        In order to investigate the effect of Sihosogansan, Sihosogansan and Desmodi Herba and Sihosogansan and Curcumae Tuber on cholecytolithiasis, ICR mice which were fed with gallstone-trigger diet was administrate extracts of Sihosogansan, Sihosogansan and Desmodi Herba and Sihosogansan and Curcumae Tuber and then observed about gallstone incidence, WBC co units in whole blood, serum total cholesterol, serum free cholesterol, serum phospholipid, serum triglyceride. The results were as follows : 1. The incidence rates of gallstone were reduced in all the experimental groups as compared with that of control group. 2. The counts of WBC were increased in control group as compared with that of normal group, while those of all the experimental groups were significantly decreased as compared with that of control group. 3. The level of serum total cholesterol was increased in control group as compared with normal group, while those of Sihosogansan group, Sihosogansan and Desmodi Herba group and Sihosogansan and Curcumae Tuber group were significantly decreased as compared with that of control group. 4. The percentage of the level of serum free cholesterol to total cholesterol was not significant because there is no difference between normal group and control group. 5. The level of serum phospholipid was increased in control group as compared with normal group, while only that of Sihosogansan and Desmodi Herba group was significantly decreased as compared with that of control group. 6. The level of serum trigryceride was increased in control group as compared with normal group, while those of Sihosogansan group, Sihosogansan and Desmodi Herba group and Sihosogansan and Curcumae Tuber group were significantly decreased as compared with that of control group.

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