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      • 急性汎發性 腹膜炎의 臨床的 考察

        文祥泰 충남대학교 대학원 1976 論文集 Vol.7 No.-

        The present report is a clinical study of 192 patients with acute panperitonitis who were admitted to the Department of General Surgery of Chungnam National University Hospital from July 1,1972 to December 31, 1975. The results obtained are as follows: 1) During this period, the patients with acute abdomen who underwent laparotomy were 556 cases. Of those 556 cases, 192 cases were acute panperitonitis and its percentage was 34.5% . 2) Of 192 cases, 46 cases(24.0%) were due to peptic ulcer perforation, 37 cases(19.3%) due to acute appendicitis perforation, 33 cases(17.2%) due to ileal perforation of salmonellosis, and 25 cases(13.0%) due to traumatic intestinal rupture. 3) The majority of patients with peptic ulcer perforation, ileal perforation in salmonellosis and traumatic intestinal repture were the 2nd to the 4th decade of men. In cases of acute appendicitis perforation, ages were evenly distributed with slight peak in the 1st to the 2nd decade and sex difference was not significant. 4) Of 46 cases of peptic ulcer perforation, 24 cases were due to gastric ulcer perforation and 22 cases were due to duodenal ulcer perforation. The ratio was 1.1 to 1. The frequent site of ileal perforation in salmonellosis was within 60cm proximal to ileo-cecal junction in 65.5% and nearly all cases were within 120 cm. In 25 cases of traumatic intestinal rupture, the frequent site of injury was jejunum and ileum in 61.6%. 5) The arrival of patients after onset of visceral perforation was markedly delayed in ileal perforation of salmonellosis(69.5%-over 24 hours) as compared with peptic ulcer perforation or traumatic intestinal rupture. 6) In operative procedures of gastroduodenal region perforations, simple closures were 34 cases and emergency resective operations were 17 cases. 7) The most frequent postoperative complication was wound infection and disruptions of 42 cases(21.9%). Ileal perforation of salmonellosis showed the highest incidence of 45.5%. 8) Of 192 cases. mortality rate was 14.06%(27 cases) and salmonellosis showed the highest rate(21.2%). 9) In the analysis of mortality cases, the death rate was greatly influenced and increased by the delayed arrival after onset of visceral perforation. The number of death was 17 cases(63.0%) within one week after operation and 19 cases(37.0%) from one week to maximum 48 days(average 21.2 days).

      • 家兎의 總輸膽管內 揷管을 通해 投與한 Ethyl Alcohol-Ethyl Ether 溶液이 肝吸蟲 및 肝實質에 미치는 影響

        文祥泰 충남대학교 의과대학 지역사회의학연구소 1980 충남의대잡지 Vol.7 No.1

        This study was undertaken to investigate the effects of chemical agents on clonorchis sinensis and host's liver tissues. In vitro, flukes were tested with ethyl alcohol-ethyl ether solution of different concentration. The experimental rabbits were infected each with 500 of metacercariae and 35 to 40 days later a polyethylene catheter of gauge No. 20 was inserted into the common bile duct of each rabbit, then ethyl alcohol-ethyl ether solution was infused through the catheter. Fifty days after infection, the rabbits were sacrificed to study the histopathological changes of the liver and to detect the infected flukes in the liver, then the following results were obtained. 1. The flukes were killed within 10 seconds in the original solution (one part of 99% ethyl alcohol plus two parts of ethyl ether), 2 to 5 minutes in 50% soluton diluted with 0.9% NaCl solution and 5 to 10 minutes in 25% solution in vitro. 2. The reduction in number of infected flukes in the ethyl alcohol-ethyl ether infusion group was 63% in average compared to the control group. 3. Necrosis and abscess of the liver parenchyma, inflammation of the bile ducts and the vessels, dilatation of the blood vessels and cirrhotic changes ware more marked in the group of ethyl alcohol-ethyl ether infusion than those seen in the other groups and directly related to the concentration of the solution. 4. The degree of the hepatic enlargement was generally proportional to the histopathological changes of the liver and inversely proportional to the body weight of the rabbits. 5. One shot of infusion with concentrated ethyl alcohol-ethyl ether solution, namely the original solution was superior to the low concentrated solution of multiple infusion for elimination of the infected flukes and induced less damages to the liver.

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