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- 저자 : Şimşek Tuncay (검색결과 3 건)
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Güler Ömer,Şimşek Tuncay,Özkul İskender,Avar Barış,Canbay Canan A.,Chattopadhyay Arun K.,Güler Seval H. 한국물리학회 2022 Current Applied Physics Vol.33 No.-
High entropy alloy (HEA) with shape memory effect (SME) has been the subject of great interest for the past few decades. However, with the increased demands for new materials for high thermal applications, the research activities on the multi elemental high entropy shape memory alloys (HESMA) have been increased by many folds recently. The nano crystalline HEA powder with shape memory effect developed in this study, HfZrTiFeMnSi, was produced by mechanical alloying (MA) for the first time. In this method equiatomic ratio of Hf, Zr, Ti, Fe, Mn, and Si were mixed together and milled by MA process for 100 h. The powder formed was of amorphous in nature. Elemental mapping of the powder from SEM-EDS revealed homogeneity of the alloying elements confirming successful fabrication of HfZrTiFeMnSi HEA powder. The DSC studies from ambient to 500 ◦C of the annealed alloy powders showed reversible austenitic to martensitic (A↔M) transformations. The A↔M transformation hysteresis seemed to vary with the milling time and annealing temperature. The enthalpy values, ΔH, for the transformation were calculated from the DSC plots using tangent method for peak area calculation. Regardless of the annealing temperature, the thermal analysis revealed that the ΔH, equilibrium temperature (T0), and crystallization temperature values decreased with the increasing milling time.
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Tufan Tarcan,Cem Akbal,Çağrı A. Şekerci,Tuncay Top,Ferruh Şimşek 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.4
Purpose: This was a prospective single-arm study to assess the efficacy and safety ofintradetrusor injections of onabotulinum toxin-A in children with urinary incontinenceassociated with neurogenic detrusor overactivity due to myelomeningocele. All patientshad failed the first-line treatment of a combination of oral antimuscarinics andintermittent catheterization. Materials and Methods: The study group consisted of 31 children with myelomeningocelewith a mean age of 7.95 years (range, 5–13 years) who were followed up for a meanof 29 weeks. The amount of onabotulinum toxin A injected was 10 U/kg with a maximaldose of 300 U. There were 20 to 30 injection sites with rigid cystoscopic guidance undergeneral anesthesia. Results: Thirty of 31 patients reported dryness between intermittent catheterizationintervals. The mean reduction in maximum detrusor pressure and the mean increasein maximum cystometric capacity from baseline were 53% and 51.5%, respectively, 6weeks after injection. We found a 324% increase in mean bladder compliance and a 57%increase in mean intermittent catheterization volumes. The mean duration of efficacywas 28 weeks with a single injection and 36 weeks for repeated injections (minimum,16 weeks; maximum, 52 weeks). The mean time interval between repeated onabotulinumtoxin-A injections was 7 months (maximum, 13 months). Intradetrusor injectionsof onabotulinum toxin-A were well tolerated. Conclusions: Onabotulinum toxin-A injections into the bladder wall provide a significantsymptomatic and urodynamic improvement in children with neurogenic detrusoroveractivity due to myelomeningocele who are on intermittent catheterization. The treatment seems to be safe and very well tolerated.
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Serap Duraklı-Velioğlu,İsmail Hakkı Boyacı,Osman Şimşek,Tuncay Gümüş 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.6
The combined effect of temperature, agitationspeed, and light on red pigment production by Monascuspurpureus (M. purpureus) Went DSM 1604 using bugdamaged wheat was studied using an artificial neuralnetwork (ANN). Information retrieved from the ANN wasused to determine the optimal operating conditions forpigment production by M. purpureus using bug damagedwheat meal. The developed ANN had R2 values fortraining, validation, and testing data sets of 0.993, 0.961,and 0.944, respectively. According to the model, thehighest pigment production of 1.874 absorbance units at510 nm (A510 nm) would be achieved at 29oC and 150 rpmunder light conditions. The mean value of the experimentalresults obtained under these optimum conditions was1.787±0.072 A510 nm, corresponding to a pigment yield of35.740 A510 nm/g. The study showed that bug damagedwheat can be used as a substrate for red pigment productionby M. purpureus.
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