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Hesperidin Protects Against High-Fat Diet-Induced Lipotoxicity in Rats by Inhibiting Pyroptosis
Ruixi Luo,Weiyi Tian,Yudie Hu,La Wang,Wenjia Wang,Ping Wang,Zunli Ke,Didong Lou 한국식품영양과학회 2024 Journal of medicinal food Vol.27 No.2
It is currently thought that excess fatty acid-induced lipotoxicity in hepatocytes is a critical initiator in thedevelopment of nonalcoholic fatty liver disease (NAFLD). Lipotoxicity can induce hepatocyte death; thus, reducing lipotoxicityis one of the most effective therapeutic methods to combat NAFLD. Abundant evidence has shown that hesperidin(HSP), a type of flavanone mainly found in citrus fruits, is able to ameliorate NAFLD, but the molecular mechanisms areunclear. We previously reported that pyroptosis contributed to NAFLD development and that inhibiting pyroptosis contributedto blunting the progression of NAFLD in rat models. Therefore, we questioned whether HSP could contribute to amelioratingNAFLD by modulating pyroptosis. In this study, a high-fat diet (HFD) induced dyslipidemia and hepatic lipotoxicity in rats,and HSP supplementation ameliorated dyslipidemia and insulin resistance. In addition, the HFD also caused pyroptosis in theliver and pancreas, while HSP supplementation ameliorated pyroptosis. In vitro, we found that HSP ameliorated palmitic acidinducedlipotoxicity and pyroptosis in HepG2 and INS-1E cells. In conclusion, we showed for the first time that HSP has aprotective effect against liver and pancreas damage in terms of pyroptosis and provides a novel mechanism for the protectiveeffects of HSP on NAFLD.
Li, Xiao,Shi, Xiaodan,Zou, Man,Luo, Yudi,Tan, Yali,Wu, Yexu,Chen, Lin,Li, Pei The Korean Society for Microbiology and Biotechnol 2015 한국미생물·생명공학회지 Vol.43 No.3
In this paper, the autolysis process of Saccharomyces cerevisiae FX-2 (S. cerevisiae FX-2) via, a variety of endogenous enzyme, was investigated systematically by analyzing changes in physicochemical parameters in autolysate, surface morphology and the internal structure of the yeast cells. As an explicit conclusion, the arisen autolysis depended on the pH and the optimal pH was found to be 5.5. Based on the experimental data and the characteristics of mycelia morphology, a hypothesis is put forward that simple proteins in yeast vacuolar are firstly degraded for utilization, and then more membrane-bound proteins are hydrolyzed to release hydrolytic enzymes, which arouse an enzymatic reaction to induce the collapse of the cell wall into the cytoplasm.
( Xiao Li ),( Xiaodan Shi ),( Man Zou ),( Yudi Luo ),( Yali Tan ),( Yexu Wu ),( Lin Chen ),( Pei Li ) 한국미생물생명공학회(구 한국산업미생물학회) 2015 한국미생물·생명공학회지 Vol.43 No.3
In this paper, the autolysis process of Saccharomyces cerevisiae FX-2 (S. cerevisiae FX-2) via, a variety of endogenous enzyme, was investigated systematically by analyzing changes in physicochemical parameters in autolysate, surface morphology and the internal structure of the yeast cells. As an explicit conclusion, the arisen autolysis depended on the pH and the optimal pH was found to be 5.5. Based on the experimental data and the characteristics of mycelia morphology, a hypothesis is put forward that simple proteins in yeast vacuolar are firstly degraded for utilization, and then more membrane- bound proteins are hydrolyzed to release hydrolytic enzymes, which arouse an enzymatic reaction to induce the collapse of the cell wall into the cytoplasm.