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Woo, Yu Ri,Kim, Jong Sic,Lim, Ji Hong,Hwang, Sewon,Kim, Miri,Bae, Jung Min,Park, Young Min,Min, Chang-Ki,Kim, Dong-Wook,Park, Hyun Jeong Elsevier 2018 JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY - Vol.78 No.3
<P><B>Background</B></P> <P>Multiple myeloma (MM) is a plasma cell dyscrasia characterized by the presence of a clonal proliferation of tumor cells. Cutaneous involvement of MM is very rare and remains poorly understood.</P> <P><B>Objective</B></P> <P>The aim of this study was to examine the clinical and histopathologic characteristics of cutaneous involvement in MM and identify factors associated with overall survival of MM with cutaneous involvement.</P> <P><B>Methods</B></P> <P>The medical records of 1228 patients with MM were retrieved and analyzed. Of those patients, 14 with cutaneous involvement of MM (1.14%) were further evaluated for their clinical and histopathologic findings.</P> <P><B>Results</B></P> <P>Patients with cutaneous involvement showed significantly reduced overall survival compared with those without cutaneous involvement (median, 28 vs. 57 months; hazard ratio, 1.929; 95% confidence interval, 1.030-3.613). In subgroup analyses of patients with MM with cutaneous involvement, erythematous nodules (<I>P</I> = .004), multiple cutaneous lesions (<I>P</I> = .002), and absence of a grenz zone (<I>P</I> = .004) were clinicopathologic features associated with reduced overall survival after Bonferroni correction.</P> <P><B>Limitations</B></P> <P>The retrospective design and the small sample size are the limitations.</P> <P><B>Conclusion</B></P> <P>Cutaneous involvement accounted for about 1.14% of patients with MM and was associated with reduced overall survival.</P>
Rosacea: Molecular Mechanisms and Management of a Chronic Cutaneous Inflammatory Condition
Woo, Yu Ri,Lim, Ji Hong,Cho, Dae Ho,Park, Hyun Jeong MDPI 2016 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.17 No.9
<P>Rosacea is a chronic cutaneous inflammatory disease that affects the facial skin. Clinically, rosacea can be categorized into papulopustular, erythematotelangiectatic, ocular, and phymatous rosacea. However, the phenotypic presentations of rosacea are more heterogeneous. Although the pathophysiology of rosacea remains to be elucidated, immunologic alterations and neurovascular dysregulation are thought to have important roles in initiating and strengthening the clinical manifestations of rosacea. In this article, we present the possible molecular mechanisms of rosacea based on recent laboratory and clinical studies. We describe the genetic predisposition for rosacea along with its associated diseases, triggering factors, and suggested management options in detail based on the underlying molecular biology. Understanding the molecular pathomechanisms of rosacea will likely aid toward better comprehending its complex pathogenesis.</P>
( Yu Ri Woo ),( Jong Sic Kim ),( Ji Hong Lim ),( Sewon Hwang ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Acanthosis nigricans (AN) is a cutaneous eruption characterized by hyperpigmention and velvety skin texture, and primarily involves the intertriginous areas such as axillae, posterior neck and inframammary folds. Unilateral linear AN is a rare form of AN, characterized by localized linear lesions or a solitary lesion following Blaschko`s line. A 15-year-old male presented with an asymptomatic, linear, localized velvety brownish plaque on his neck that had been present for 5 months. He obtained a linear scratch mark on the anterior neck 6 months prior after climbing over a fence. In addition, symmetrically distributed, velvety, gray-brown, hyperpigmented patches on both axilla were observed. Skin biopsies were performed of the anterior neck and axillae, respectively. Histopathological examination of both lesions revealed papillomatosis, hyperkeratosis, and mild acanthosis of the epidermis. In this case, the patient already had hyperpigmented patches on the axillae before the appearance of the linear AN on the neck, implying that in patients with benign AN, the linear form of AN can occur in association with the Koebner phenomenon. We hypothesize that trauma might act as a trigger of AN, resulting in abnormal growth factor signaling pathways. Therefore, we suggest that in patients with AN, careful examination and regular follow-up are needed and the patient should avoid further trauma because this could trigger the development of AN
( Yu Ri Woo ),( Kyung Eun Jung ),( Dae Won Koo ),( Joong Sun Lee ) 대한피부과학회 2015 Annals of Dermatology Vol.27 No.4
Background: Chronic urticaria is defined as repeated episodes of wheals lasting for 6 weeks or longer. Nowadays, the role of vitamin D in various chronic diseases is a matter of great interest, but limited data is available on the vitamin D status in patients with chronic urticaria. Objective: The goal of this study was to investigate the relationship between vitamin D status and clinical characteristics of chronic urticaria. Methods: The clinical records of 72 patients with chronic urticaria, 26 with acute urticaria and 26 with atopic dermatitis, along with 72 healthy controls, were retrospectively reviewed. Results: The serum 25-(OH)D3 level was found to be significantly reduced in patients with chronic urticaria compared to those in the other groups. In particular, the proportion of patients with critically low vitamin D levels (<10 ng/ml) was significantly higher in the chronic urticaria group than in the other groups. The serum vitamin D levels showed significant negative associations with urticaria activity score and disease duration. In addition, serum vitamin D levels were significantly lower in subjects with a positive autologous serum skin test than in subjects with a negative result. Conclusion: In conclusion, the serum vitamin D level was more likely to be critically low in patients with chronic urticaria, and an inverse relationship with disease severity and disease duration was observed. These findings may open up the possibility of the clinical use of vitamin D as a contributing factor in the pathogenesis of chronic urticaria and a predictive marker for disease activity in chronic urticaria. (Ann Dermatol 27(4) 423∼430, 2015)