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( Yoshiaki Yoshida ),( Takeshi Endo ) 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
Recently, we have reported that polyaddition of various diisothiocyanates and dithiols is achieved with triethylamine in DMF at 25 °C for 12 h under nitrogen atmosphere to obtain the corresponding polydithiourethanes (PDTU) in higher yield and molecular weight. Particularly, PDTU containing an aliphatic moiety in the main-chain exhibited excellent optical and mechanical properties compared to that of typical polyurethanes. In this study, aliphatic PDTUs were synthesized from various diisothiocyanates and dithiols having a difference of carbon number, and then the chemical and physical properties of the obtained PDTUs such as solvent solubility, glass transition temperature, thermal stability, transparency, refractive index, and tensile strength, were analyzed in detail by GPC, NMR, IR-ATR, UV-vis, DSC, TGA, tensile testing measurements. Moreover, the cast films obtained from multifunctional multifunctional isothiocyanate and thiols exhibited excellent chemical and physical properties.
Development of a Brain-Computer Interface using Steady State Visual Evoked Potential
Yoshiaki YOSHIDA,Junichi USHIBA,Yutaka TOMITA 대한인간공학회 2007 대한인간공학회 학술대회논문집 Vol.- No.-
Visual Evoked Potential (VEP) is a damped oscillation-like reaction brain wave obtained from a cerebrum vision field by visual stimulation lasting almost one second. VEP is divided into two categories. One is a transient VEP (t-VEP) observed with low stimulation cycle, and the other is a steady-state VEP (ss-VEP) observed with high stimulation cycle. The former is the reaction wave for every stimulus, while the latter is the fused waveform of t-VEPs, and observed as sinusoid. Since ss-VEP is known to synchronize with the stimulation wave, from the brain wave we can decide the illumination frequency. This study aims the development of a device, which can recognize the LED at which patient gazes, when several light emitting diodes (LEDs) illuminating with different driving frequencies. By assigning the LEDs to specific functions, such as calling caregivers, opening/closing a curtain, ON/OFF of TV set, our device can work as an input part of an environment control system for quadriplegic patients. Our device records brain wave from electrodes mounted on ear pads and nose pads of an eyeglass frame, rather than from electrodes on vision cortex, while the SNR was much smaller than vision cortex lead. In order to overcome the less SNR signal processing was employed. The measured brain wave with eyeglass frame electrodes was analyzed with FFT and Autoregressive-model estimate, and we could identify the light source that the patients stared.
Yoshida, Yoshiaki,Fujiwara, Koji,Ishihara, Yoshiyuki,Suzuki, Hirokazu The Korean Institute of Electrical Engineers 2013 The Journal of International Council on Electrical Vol.3 No.1
When distributed generators such as photovoltaic (PV) systems spread widely in distribution networks, it is important to detect islanding caused by power system fault for ensuring electrical safety. We developed the nonlinear magnetizing characteristics model of a pole transformer for analyzing islanding-prevention of PV system. Basic experiments of the islanding-detection were conducted by using the RLC resonant circuit for verification of the developed model. Analytical results by the proposed model agreed well with experimental results.
Yoshida, Yoshiaki,Fujiwara, Koji,Ishihara, Yoshiyuki,Suzuki, Hirokazu Journal of International Conference on Electrical 2014 Journal of international Conference on Electrical Vol.3 No.3
When large penetration of the distributed generators (DGs) such as photovoltaic (PV) systems is growing up in grid system, it is important to quickly prevent islanding caused by power system fault to ensure electrical safety. We propose a novel active method for islanding prevention by harmonic injection synchronized with the exciting current harmonics of the pole transformer to avoid mutual interference between active signals. We confirm the validity of the proposed method by performing the basic tests of islanding by using a current source superimposed the harmonic active signal. Further, we carry out the simulation using PSCAD/EMTDC, and verify the fast islanding detection.
Marumo Yoshiaki,Yoshida Takashi,Furukawa Yuki,Ina Kenji,Kamiya Ayumi,Kataoka Takae,Kayukawa Satoshi 대한백신학회 2023 Clinical and Experimental Vaccine Research Vol.12 No.4
Purpose: Patients with hematological malignancies are at an increased risk of severe infection with coronavirus disease 2019 (COVID-19). However, developing an adequate immune response after vaccination is difficult, especially in patients with lymphoid neoplasms. Since the long-term effects of the BNT162b2 vaccine are unclear, the humoral immune response 5 months after the two vaccinations in patients with hematological disorders was analyzed. Materials and Methods: Samples were collected from 96 patients vaccinated twice with BNT162b2 and treated with at least one line of an antitumor or immunosuppressive drug in our hospital from November 2021 to February 2022. Serum anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) spike (S) antibody titers were analyzed. Patients were age- and sex-matched using propensity matching and compared with a healthy control group. Patients with serum anti-SARS-CoV-2 S antibodies were defined as ‘responder’ if >50 U/mL. The patients had B-cell non-Hodgkin lymphoma (B-NHL), multiple myeloma, chronic myeloid leukemia, etc. Results: Patients had significantly low antibody levels (median, 55.3 U/mL vs. 809.8 U/mL; p<0.001) and a significantly low response rate (p<0.001). Multivariate analysis showed that patients with B-NHL, aged >72 years, were associated with a low response to vaccination. There were no significant differences between patients with chronic myeloid leukemia and healthy controls. Conclusion: Our study shows that patients with hematological disorders are at risk of developing severe COVID-19 infections because of low responsiveness to vaccination. Moreover, the rate of antibody positivity differed between the disease groups. Further studies are warranted to determine an appropriate preventive method for these patients, especially those with B-NHL.
( Shinji Ishii ),( Suguru Fukahori ),( Kimio Asagiri ),( Yoshiaki Tanaka ),( Nobuyuki Saikusa ),( Naoki Hashizume ),( Motomu Yoshida ),( Daisuke Masui ),( Naoko Komatsuzaki ),( Naruki Higashidate ),( 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2017 Journal of Neurogastroenterology and Motility (JNM Vol.23 No.4
Background/Aims The aim of this study is to investigate the degree of delayed gastric emptying (DGE) and evaluate how the severity of DGE affects gastroesophageal reflux disease (GERD) in neurologically impaired (NI) patients utilizing 24-hour multichannel intraluminal impedance pH measurements (pH/MII) and <sup>13</sup>C-acetate breath test (<sup>13</sup>C-ABT) analyses. Methods <sup>13</sup>C-ABT and pH/MII were conducted in 26 NI patients who were referred to our institution due to suspected GERD. At first, correlation analyses were performed to investigate the correlation between the <sup>13</sup>C-ABT parameters and the clinical or pH/MII parameters. Thereafter, all patients were divided into 2 groups (DGE and severe DGE [SDGE] group) according to each cut off half emptying time (t<sub>1/2</sub>, 90-170 minutes). Each pH/MII parameter was compared between the 2 groups in each set-up cutoff t<sub>1/2</sub>. Results The mean t<sub>1/2</sub> of all patients was 215.5 ± 237.2 minutes and the t<sub>1/2</sub> of 24 (92.3%) patients were > 100 minutes. Significant moderate positive correlations were observed between both t1/2 and lag phase time and the non-acid reflux related parameters. Furthermore, the patients in the SDGE group demonstrated higher non-acid reflux related parameters than those of the DGE groups when the cutoff was t<sub>1/2</sub> ≥ 140 minutes. Conclusion The present study demonstrated that GE with t<sub>1/2</sub> ≥ 140 minutes was related to an increase of non-acid exposure reaching up to the proximal esophagus in NI patients, and indicating that NI patients with SDGE might have a high risk of non-acid GERD. (J Neurogastroenterol Motil 2017;23:533-540)