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RISS 인기검색어
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- 저자 : ( Yichen Shen ) (검색결과 5 건)
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( Suqin Shen ),( Jie Zuo ),( Huan Feng ),( Meirong Bai ),( Chenji Wang ),( Youheng Wei ),( Yanhong Li ),( Yichen Le ),( Jiaxue Wu ),( Yanhua Wu ),( Long Yu ) 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.6
T-complex protein 10A homolog 2 (TCP10L) was previously demonstrated to be a potential tumor suppressor in human hepatocellular carcinoma (HCC). However, little is known about the molecular mechanism. MAX dimerization protein 1 (MAD1) is a key transcription suppressor that is involved in regulating cell cycle progression and Myc-mediated cell transformation. In this study, we identified MAD1 as a novel TCP10L-interacting protein. The interaction depends on the leucine zipper domain of both TCP10L and MAD1. TCP10L, but not the interaction-deficient TCP10L mutant, synergizes with MAD1 in transcriptional repression, cell cycle G1 arrest and cell growth suppression. Mechanistic exploration further revealed that TCP10L is able to stabilize intracellular MAD1 protein level. Consistently, the MAD1-interaction-deficient TCP10L mutant exerts no effect on stabilizing the MAD1 protein. Taken together, our results strongly indicate that TCP10L stabilizes MAD1 protein level through direct interaction, and they cooperatively regulate cell cycle progression. [BMB Reports 2016; 49(6): 325-330]
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Mengnan Qu,Yichen Zhou,Lili Ma,Yi Zhang,Jiaxin Wang,Shanxin Xiong,Lihua Shen,Jinmei He 한국섬유공학회 2021 Fibers and polymers Vol.22 No.3
Stimulus-responsive materials with controllable oil/water separation performance have prodigious potentialapplication. Here, a new thought for low-cost, time-saving, flexible approach has been developed to prepare a pH-responsivematerial with switchable superamphiphobicity and superoleophobicity-superhydrophilicity. The as-prepared material can beeasily applied onto multifarious substrates and presents stable superamphiphobicity. However, when the modified material istreated by alkaline solution, its surface wettability turns superhydrophilicity and superoleophobicity, thus water is allowed topenetrate through the material whereas the oil was blocked on the surface. Moreover, the surface wettability can be recoveredto superamphiphobicity quickly via treating the material with acidic aqueous. Hence, such a controllable water wettabilityand stable oil repellency property endows the as-prepared material with excellent capability to separate water from oil/watermixture. In addition, the pH-responsive materials can maintain switchable wettability after being treated by acid and alkalinumerous cycles. Furthermore, the obtained materials also exhibit excellent recyclable, self-cleaning and flame-resistantperformance, which shows potential applications for smart water-oil separators and fire-shielding protectors.
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Ciphertext-Policy Attribute-Based Encryption with Hidden Access Policy and Testing
( Jiguo Li ),( Haiping Wang ),( Yichen Zhang ),( Jian Shen ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.7
In ciphertext-policy attribute-based encryption (CP-ABE) scheme, a user`s secret key is associated with a set of attributes, and the ciphertext is associated with an access policy. The user can decrypt the ciphertext if and only if the attribute set of his secret key satisfies the access policy specified in the ciphertext. In the present schemes, access policy is sent to the decryptor along with the ciphertext, which means that the privacy of the encryptor is revealed. In order to solve such problem, we propose a CP-ABE scheme with hidden access policy, which is able to preserve the privacy of the encryptor and decryptor. And what`s more in the present schemes, the users need to do excessive calculation for decryption to check whether their attributes match the access policy specified in the ciphertext or not, which makes the users do useless computation if the attributes don`t match the hidden access policy. In order to solve efficiency issue, our scheme adds a testing phase to avoid the unnecessary operation above before decryption. The computation cost for the testing phase is much less than the decryption computation so that the efficiency in our scheme is improved. Meanwhile, our new scheme is proved to be selectively secure against chosen-plaintext attack under DDH assumption.
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( Qianqian Pang ),( Yuming Wang ),( Mingyuan Xu ),( Jiachao Xu ),( Shengquan Xu ),( Yichen Shen ),( Jinghong Xu ),( Rui Lei ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.3
Keloids are the most common pathological form of trauma healing, with features that seriously affect appearance and body function, are difficult to treat and have a high recurrence rate. Emerging evidence suggests that miRNAs are involved in a variety of pathological processes and play an important role in the process of fibrosis. In this study, we investigated the function and regulatory network of miR-152-5p in keloids. The miRNA miR-152-5p is frequently downregulated in keloid tissue and primary cells compared to normal skin tissue and fibroblasts. In addition, the downregulation of miR-152-5p is significantly associated with the proliferation, migration and apoptosis of keloid cells. Overexpression of miR-152-5p significantly inhibits the progression of fibrosis in keloids. Smad3 is a direct target of miR-152-5p, and knockdown of Smad3 also inhibits fibrosis progression, consistent with the overexpression of miR-152-5p. The interaction between miR-152-5p and Smad3 occurs through the Erk1/2 and Akt pathways and regulates collagen3 production. In summary, our study demonstrates that miR-152-5p/Smad3 regulatory pathways involved in fibrotic progression may be a potential therapeutic target of keloids. [BMB Reports 2019; 52(3): 202-207]
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Research on damage of 3D random aggregate concrete model under ultrasonic dynamic loading
Lixiao Wang,Qidong Chen,Xin Liu,Bin Zhang,Yichen Shen 사단법인 한국계산역학회 2020 Computers and Concrete, An International Journal Vol.26 No.1
Concrete are the most widely used manmade materials for infrastructure construction across the world. These constructions gradually aged and damaged due to long-term use. However, there does not exist an efficient concrete recycling method with low energy consumption. In this study, concrete was regarded as a heterogeneous material composed of coarse aggregate and cement mortar. And the failure mode of concrete under ultrasonic dynamic loading was investigated by finite element (FE) analysis. Simultaneously, a 3D random aggregate concrete model was programmed by APDL and imported into ABAQUS software, and the damage plastic constitutive model was applied to each phase to study the damage law of concrete under dynamic loading. Meanwhile, the dynamic damage process of concrete was numerically simulated, which observed ultrasonic propagating and the concrete crushing behavior. Finally, the FE simulation considering the influence of different aggregate volume and aggregate size was carried out to illustrate the damage level of concrete.
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