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RISS 인기검색어
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- 저자 : ( Yi-jo Jeung ) (검색결과 4 건)
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Krukenberg tumors of gastric origin versus colorectal origin
( Yi Jo Jeung ),( Hee Jae Ok ),( Won Gyu Kim ),( Sung Han Kim ),( Tae Hwa Lee ) 대한산부인과학회 2015 Obstetrics & Gynecology Science Vol.58 No.1
Objective The aim of this study is to compare the each clinical manifestation related with its mean survival time of Krukenberg tumors (KTs) of gastric origin versus with that of colorectal origin. Methods A total of 156 consecutive patients diagnosed with KTs of the ovary who underwent surgical treatment at a single institution between 2001 and 2010 were retrospectively evaluated. Each clinical manifestation related with its mean survival time compared two different groups. Survival analyses and comparisons were performed using the Kaplan- Meier method. Results Among the 156 patients with KT, 111 patients with KTs of gastric origin and 45 patients with KTs of colorectal origin were identified. For all patients with KTs, median survival time was 22.7 months. Each mean survival time among all patients with KTs of gastric origin and colorectal origin was 19.2 months and 27.3 months. The results showed that mean survival time of postmenopausal patients was 19.0 months compared with 32.5 months for premenopausalpatients (P=0.015). Among all patients, mean survival time of those with metachronous cancer was longer than those with synchronous cancer (P=0.001). In all cases, especially when only one ovary was invaded, the mean survival time was relatively higher (P=0.001). Conclusion Patients with KTs of colorectal origin had a better prognosis than those of gastric origin. In all cases of KT, the meansurvival time was significantly longer in postmenoposal patients, metachronous disease and unilateral ovarian involvement. Notably, synchronous, ascites positive, and ovary only metastasis showed more longer mean survival time in the KTs of colorectal origin than KTs of gastric origin.
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Yi, Sang Ah,Lee, Jieun,Park, Sun Kyu,Kim, Jeom Yong,Park, Jong Woo,Lee, Min Gyu,Nam, Ki Hong,Park, Jee Hun,Oh, Hwamok,Kim, Saetbyul,Han, Jihoon,Kim, Bo Kyung,Jo, Dong-Gyu,Han, Jeung-Whan The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.1
Background: The biological and pharmacological effects of BST204, a fermented ginseng extract, have been reported in various disease conditions. However, its molecular action in metabolic disease remains poorly understood. In this study, we identified the antiadipogenic activity of BST204 resulting from its inhibition of the S6 kinase 1 (S6K1) signaling pathway. Methods: The inhibitory effects of BST204 on S6K1 signaling were investigated by immunoblot, nuclear fractionation, immunoprecipitation analyses. The antiadipogenic effect of BST204 was evaluated by measuring mRNA levels of adipogenic genes and by chromatin immunoprecipitation and quantitative real-time polymerase chain reaction analysis. Results: Treatment with BST204 inhibited activation and nuclear translocation of S6K1, further decreasing the interaction between S6K1 and histone H2B in 10T1/2 mesenchymal stem cells. Subsequently, phosphorylation of H2B at serine 36 (H2BS36p) by S6K1 was reduced by BST204, inducing an increase in the mRNA expression of Wnt6, Wnt10a, and Wnt10b, which disturbed adipogenic differentiation and promoted myogenic and early osteogenic gene expression. Consistently, BST204 treatment during adipogenic commitment suppressed the expression of adipogenic marker genes and lipid drop formation. Conclusion: Our results indicate that BST204 blocks adipogenesis of mesenchymal stem cells through the inhibition of S6K1-mediated histone phosphorylation. This study suggests the potential therapeutic strategy using BST204 to combat obesity and musculoskeletal diseases.
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Sang Ah Yi,Jieun Lee,Sun Kyu Park,Jeom Yong Kim,Jong Woo Park,Min Gyu Lee,Ki Hong Nam,Jee Hun Park,Hwamok Oh,Saetbyul Kim,Jihoon Han,Bo Kyung Kim,Dong-Gyu Jo,Jeung-Whan Han 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.1
Background: The biological and pharmacological effects of BST204, a fermented ginseng extract, havebeen reported in various disease conditions. However, its molecular action in metabolic disease remainspoorly understood. In this study, we identified the antiadipogenic activity of BST204 resulting from itsinhibition of the S6 kinase 1 (S6K1) signaling pathway. Methods: The inhibitory effects of BST204 on S6K1 signaling were investigated by immunoblot, nuclearfractionation, immunoprecipitation analyses. The antiadipogenic effect of BST204 was evaluated bymeasuring mRNA levels of adipogenic genes and by chromatin immunoprecipitation and quantitativereal-time polymerase chain reaction analysis. Results: Treatment with BST204 inhibited activation and nuclear translocation of S6K1, furtherdecreasing the interaction between S6K1 and histone H2B in 10T1/2 mesenchymal stem cells. Subsequently,phosphorylation of H2B at serine 36 (H2BS36p) by S6K1 was reduced by BST204, inducing anincrease in the mRNA expression of Wnt6, Wnt10a, and Wnt10b, which disturbed adipogenic differentiationand promoted myogenic and early osteogenic gene expression. Consistently, BST204 treatmentduring adipogenic commitment suppressed the expression of adipogenic marker genes and lipid dropformation. Conclusion: Our results indicate that BST204 blocks adipogenesis of mesenchymal stem cells through theinhibition of S6K1-mediated histone phosphorylation. This study suggests the potential therapeuticstrategy using BST204 to combat obesity and musculoskeletal diseases.
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( Sung-hun Min ),( Ja-seong Koo ),( Hyun-jung Kim ),( Yi-jo Jeung ),( Hwa-sook Moon ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: LAH was proposed to improve the implantation rate in FET cycles, but conflicting information exists in the literature with respect to the efficacy of AH in FET cycles. Methods: Embryo freezing was performed by vitrification at the cleavage stage 3 days after oocyte retrieval. Frozen embryos were thawed on the day of FET cycle. In the LAH group, zona thinning was performed by an experienced embryologist using a RI laser. During the operation, the outer half of the zona pellucida over a quarter of the diameter of the zona was removed. In the control group, embryos were replaced without LAH. Pregnancy and implantation rates were compared, p-value of <0.05 was considered statistically significant. Results: There were no differences in age of women at embryo freezing/thawing, body mass index, duration of infertility, primary/secondary infertility, cause of infertility, basal serum FSH concentration, cycle number, percentage of smokers or number of embryos frozen between the LAH group and the control group. The HMG dosage and duration and number of eggs retrieved/fertilized of the index stimulated cycle did not differ. However, pregnancy rates (43.5 vs 37.2%), and ongoing implantation rates (19.2 vs 16.3%) were higher in LAH treatment group compared to control, but these differences did not reach statistical significance. Conclusion: The findings of this study indicate that LAH treatment improves implantation and clinical pregnancy rates in women undergoing frozen-thawed embryo transfer. Furthermore, this treatment may be considered as a preferable strategy during the IVF treatment. However, this method does not seem to completely resolve the FET cycle.
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