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RISS 인기검색어
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- 저자 : ( Xinye Lin ) (검색결과 4 건)
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Lin, Yingjia,Jiang, Dan,Li, Yang,Han, Xinye,Yu, Di,Park, Jeong Hill,Jin, Ying-Hua The Korean Society of Ginseng 2015 Journal of Ginseng Research Vol.39 No.1
Background: Sun ginseng (SG), a specific formulation of quality-controlled red ginseng, contains approximately equal amounts of three major ginsenosides (RK1, Rg3, and Rg5), which reportedly has antitumor-promoting activities in animal models. Methods: MTT assay was used to assess whether SG can potentiate the anticancer activity of epirubicin or paclitaxel in human cervical adenocarcinoma HeLa cells, human colon cancer SW111C cells, and SW480 cells; apoptosis status was analyzed by annexin V-FITC and PI and analyzed by flow cytometry; and apoptosis pathway was studied by analysis of caspase-3, -8, and -9 activation, mitochondrial accumulation of Bax and Bak, and cytochrome c release. Results: SG remarkably enhances cancer cell death induced by epirubicin or paclitaxel in human cervical adenocarcinoma HeLa cells, human colon cancer SW111C cells, and SW480 cells. Results of the mechanism study highlighted the cooperation between SG and epirubicin or paclitaxel in activating caspase-3 and -9 but not caspase-8. Moreover, SG significantly increased the mitochondrial accumulation of both Bax and Bak triggered by epirubicin or paclitaxel as well as the subsequent release of cytochrome c in the targeted cells. Conclusion: SG significantly potentiated the anticancer activities of epirubicin and paclitaxel in a synergistic manner. These effects were associated with the increased mitochondrial accumulation of both Bax and Bak that led to an enhanced cytochrome c release, caspase-9/-3 activation, and apoptosis. Treating cancer cells by combining epirubicin and paclitaxel with SG may prove to be a novel strategy for enhancing the efficacy of the two drug types.
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Yingjia Lin,Dan Jiang,Yang Li,Xinye Han,Di Yu,박정일,Ying-Hua Jin 고려인삼학회 2015 Journal of Ginseng Research Vol.39 No.1
Background: Sun ginseng (SG), a specific formulation of quality-controlled red ginseng, containsapproximately equal amounts of three major ginsenosides (RK1, Rg3, and Rg5), which reportedly hasantitumor-promoting activities in animal models. Methods: MTT assay was used to assess whether SG can potentiate the anticancer activity of epirubicin orpaclitaxel in human cervical adenocarcinoma HeLa cells, human colon cancer SW111C cells, and SW480cells; apoptosis status was analyzed by annexin V-FITC and PI and analyzed by flow cytometry; andapoptosis pathway was studied by analysis of caspase-3, -8, and -9 activation, mitochondrial accumulationof Bax and Bak, and cytochrome c release. Results: SG remarkably enhances cancer cell death induced by epirubicin or paclitaxel in human cervicaladenocarcinoma HeLa cells, human colon cancer SW111C cells, and SW480 cells. Results of the mechanismstudy highlighted the cooperation between SG and epirubicin or paclitaxel in activating caspase-3and -9 but not caspase-8. Moreover, SG significantly increased the mitochondrial accumulation of bothBax and Bak triggered by epirubicin or paclitaxel as well as the subsequent release of cytochrome c in thetargeted cells. Conclusion: SG significantly potentiated the anticancer activities of epirubicin and paclitaxel in a synergisticmanner. These effects were associated with the increased mitochondrial accumulation of bothBax and Bak that led to an enhanced cytochrome c release, caspase-9/-3 activation, and apoptosis. Treating cancer cells by combining epirubicin and paclitaxel with SG may prove to be a novel strategy forenhancing the efficacy of the two drug types.
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Yingjia Lin,Dan Jiang,Yang Li,Xinye Han,Di Yu,Jeong Hill Park,Ying-Hua Jin 고려인삼학회 2015 Journal of Ginseng Research Vol.39 No.3
Background: Sun ginseng (SG), a specific formulation of quality-controlled red ginseng, contains approximately equal amounts of three major ginsenosides (RK1, Rg3, and Rg5), which reportedly has antitumor-promoting activities in animal models. Methods: MTT assay was used to assess whether SG can potentiate the anticancer activity of epirubicin or paclitaxel in human cervical adenocarcinoma HeLa cells, human colon cancer SW111C cells, and SW480 cells; apoptosis status was analyzed by annexin V-FITC and PI and analyzed by flow cytometry; and apoptosis pathway was studied by analysis of caspase-3, -8, and -9 activation, mitochondrial accumulation of Bax and Bak, and cytochrome c release. Results: SG remarkably enhances cancer cell death induced by epirubicin or paclitaxel in human cervical adenocarcinoma HeLa cells, human colon cancer SW111C cells, and SW480 cells. Results of the mechanism study highlighted the cooperation between SG and epirubicin or paclitaxel in activating caspase-3 and -9 but not caspase-8. Moreover, SG significantly increased the mitochondrial accumulation of both Bax and Bak triggered by epirubicin or paclitaxel as well as the subsequent release of cytochrome c in the targeted cells. Conclusion: SG significantly potentiated the anticancer activities of epirubicin and paclitaxel in a synergistic manner. These effects were associated with the increased mitochondrial accumulation of both Bax and Bak that led to an enhanced cytochrome c release, caspase-9/-3 activation, and apoptosis. Treating cancer cells by combining epirubicin and paclitaxel with SG may prove to be a novel strategy for enhancing the efficacy of the two drug types.
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( Xiangxu Meng ),( Xinye Lin ),( Xiaodong Wang ),( Xingming Zhou ) 한국인터넷정보학회 2012 KSII Transactions on Internet and Information Syst Vol.6 No.12
Compared with traditional itinerary planning, intention-oriented itinerary recommendations can provide more flexible activity planning without requiring the user`s predetermined destinations and is especially helpful for those in unfamiliar environments. The rank and classification of points of interest (POI) from location-based social networks (LBSN) are used to indicate different user intentions. The mining of vehicles` physical trajectories can provide exact civil traffic information for path planning. This paper proposes a POI category-based itinerary recommendation framework combining physical trajectories with LBSN. Specifically, a Voronoi graph-based GPS trajectory analysis method is utilized to build traffic information networks, and an ant colony algorithm for multi-object optimization is implemented to locate the most appropriate itineraries. We conduct experiments on datasets from the Foursquare and GeoLife projects. A test of users` satisfaction with the recommended items is also performed. Our results show that the satisfaction level reaches an average of 80%.
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